Protein: Q9NYB9

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NYB9 (Uniprot) ABI2_HUMAN ABI2 Abl interactor 2 human No
Uniprot: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 254, 664 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 353 1.88e-02 4.66e-37
GO:0019538 protein metabolic process 254, 664 GO:0016070 RNA metabolic process 715 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
93 GO:0034645 cellular macromolecule biosynthetic process
93 GO:0034654 nucleobase-containing compound biosynthetic process
93 GO:0019538 protein metabolic process
93 GO:0051252 regulation of RNA metabolic process
93 GO:0010468 regulation of gene expression
121 GO:0010467 gene expression
121 GO:0060255 regulation of macromolecule metabolic process
121 GO:0007165 signal transduction
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
279 GO:0060255 regulation of macromolecule metabolic process
353 GO:0000398 mRNA splicing, via spliceosome
456 GO:0010467 gene expression
456 GO:0090304 nucleic acid metabolic process
603 GO:0060255 regulation of macromolecule metabolic process
664 GO:0044267 cellular protein metabolic process
664 GO:0010467 gene expression
664 GO:0090304 nucleic acid metabolic process
664 GO:0060255 regulation of macromolecule metabolic process
664 GO:0007165 signal transduction
681 GO:0008380 RNA splicing
681 GO:0006397 mRNA processing
681 GO:0051252 regulation of RNA metabolic process
681 GO:0010468 regulation of gene expression
715 GO:0006396 RNA processing
715 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
84 GO:0005634 nucleus
93 GO:0005829 cytosol
93 GO:0005634 nucleus
121 GO:0005634 nucleus
140 GO:0043232 intracellular non-membrane-bounded organelle
179 GO:0012505 endomembrane system
185 GO:0005829 cytosol
254 GO:0005829 cytosol
254 GO:0005634 nucleus
298 GO:0015630 microtubule cytoskeleton
329 GO:0005829 cytosol
329 GO:0005634 nucleus
353 GO:0005654 nucleoplasm
438 GO:0005634 nucleus
603 GO:0005634 nucleus
633 GO:0005829 cytosol
633 GO:0031982 vesicle
647 GO:0005829 cytosol
664 GO:0005829 cytosol
664 GO:0043232 intracellular non-membrane-bounded organelle
664 GO:0005634 nucleus
681 GO:0005654 nucleoplasm
715 GO:0031981 nuclear lumen
735 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006928 movement of cell or subcellular component IDA
GO:0007010 cytoskeleton organization TAS
GO:0008154 actin polymerization or depolymerization NAS
GO:0016032 viral process IEA
GO:0016477 cell migration TAS
GO:0016601 Rac protein signal transduction IDA
GO:0018108 peptidyl-tyrosine phosphorylation IDA
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm TAS
GO:0005829 cytosol IDA
GO:0005856 cytoskeleton IEA
GO:0030027 lamellipodium IDA
GO:0030175 filopodium IDA
GO:0031209 SCAR complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
TFP11_HUMAN No
PR20D_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
HSF2B_HUMAN No
IHO1_HUMAN No
ENKD1_HUMAN No
A0A024R8L2_HUMAN No
CRX_HUMAN No
VINEX_HUMAN No
KRT34_HUMAN No
K2C75_HUMAN No
K1C13_HUMAN No
K1C15_HUMAN No
NUP62_HUMAN No
NHSL2_HUMAN No
KIFC3_HUMAN No
3BP1_HUMAN No
AAPK1_HUMAN No
AAPK2_HUMAN No
ABI1_HUMAN No
ABI3_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
ABLM3_HUMAN No
ADA19_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
AKAP9_HUMAN No
AKP8L_HUMAN No
ANR55_HUMAN No
AP180_HUMAN No
ARMC7_HUMAN No
ATP23_HUMAN No
BAG4_HUMAN No
BIN3_HUMAN No
BL1S6_HUMAN No
BORC6_HUMAN No
BRK1_HUMAN No
C102B_HUMAN No
C170L_HUMAN No
CA109_HUMAN No
CASC1_HUMAN No
CC115_HUMAN No
CCD57_HUMAN No
CCHCR_HUMAN No
CENPH_HUMAN No
CEP44_HUMAN No
CO059_HUMAN No
COG3_HUMAN No
COLI_HUMAN No
CS054_HUMAN No
CSKI2_HUMAN No
CYFP1_HUMAN No
DCTN2_HUMAN No
DISC1_HUMAN Yes: Q9NRI5 (MoonDB)
DLGP2_HUMAN No
DLGP4_HUMAN No
DMBX1_HUMAN No
DTNB_HUMAN No
EFS_HUMAN No
EGLN3_HUMAN No
EIF3H_HUMAN No
ES8L1_HUMAN No
F161B_HUMAN No
F214B_HUMAN No
F90A1_HUMAN No
FHL5_HUMAN No
FX4L1_HUMAN No
FXL19_HUMAN No
GA2L2_HUMAN No
GCC1_HUMAN No
GFAP_HUMAN No
GGN_HUMAN No
GPAN1_HUMAN No
HGS_HUMAN No
HHEX_HUMAN No
HNRPK_HUMAN Yes: P61978 (MoonDB)
HOME3_HUMAN No
IFT20_HUMAN No
IN80B_HUMAN No
INCA1_HUMAN No
K1C14_HUMAN No
K1C19_HUMAN No
K1C20_HUMAN No
K1C24_HUMAN No
K1C27_HUMAN No
K1H1_HUMAN No
KRT36_HUMAN No
KT33B_HUMAN No
LARGN_HUMAN No
LEG9B_HUMAN No
LENG1_HUMAN No
LHX3_HUMAN No
LMO3_HUMAN No
LMO4_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
LURA1_HUMAN No
LZTS2_HUMAN No
MAGA1_HUMAN No
MIPT3_HUMAN No
MOFA1_HUMAN No
MR1L1_HUMAN No
MS18B_HUMAN No
MYOG_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
NCKP1_HUMAN No
NFASC_HUMAN No
NLGN1_HUMAN No
PAK2_HUMAN No
PCD10_HUMAN No
PCD17_HUMAN No
PCM1_HUMAN Yes: Q15154 (MoonDB)
PDLI7_HUMAN No
PFD5_HUMAN No
PHF1_HUMAN No
PIN1_HUMAN No
PKHN1_HUMAN No
PPIF_HUMAN No
PRAM_HUMAN No
PWP2B_HUMAN No
Q0VDC6_HUMAN No
Q49AR9_HUMAN No
RABE1_HUMAN No
RASD1_HUMAN No
RBTN1_HUMAN No
RBTN2_HUMAN No
RHG32_HUMAN No
RM44_HUMAN No
RNPS1_HUMAN No
RPP25_HUMAN No
RSP14_HUMAN No
RUSC1_HUMAN No
SDCB1_HUMAN Yes: O00560 (MoonDB)
SEGN_HUMAN No
SESQ1_HUMAN No
SKAP_HUMAN No
SKT_HUMAN No
SMRD1_HUMAN No
SNAPN_HUMAN No
SNP23_HUMAN No
SNX18_HUMAN No
SNX7_HUMAN No
SPN90_HUMAN No
STAM2_HUMAN No
STX19_HUMAN No
STX4_HUMAN No
SYVM_HUMAN No
TPM2_HUMAN No
TRI32_HUMAN No
TRIMM_HUMAN No
TRIP6_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
UBQL2_HUMAN Yes: Q9UHD9 (MoonDB)
USBP1_HUMAN No
VASP_HUMAN Yes: P50552 (MoonDB)
VINC_HUMAN No
WASC3_HUMAN No
WASF1_HUMAN No
WASF3_HUMAN No
WASL_HUMAN No
WIPF1_HUMAN No
WWOX_HUMAN No
ZGPAT_HUMAN No
ZMY12_HUMAN No
PMID Article Title
7590236 Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.
8649853 Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene.
10498863 Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity.
11516653 The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648 A quantitative atlas of mitotic phosphorylation.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21107423 Structure and control of the actin regulatory WAVE complex.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25121749 HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.
No results found.
Domain Name Domain ID Source
G01936 G01936 PIR
T_SNARE_dom IPR000727 InterPro
SH3_domain IPR001452 InterPro
Abl-interactor_HHR_dom IPR012849 InterPro
ABI IPR028457 InterPro
Abi2_SH3 IPR035726 InterPro
SH3-like_dom_sf IPR036028 InterPro
ABI2 IPR036993 InterPro
Abi_HHR PF07815 Pfam
SH3_9 PF14604 Pfam
SH3DOMAIN PR00452 PRINTS
SH3 PS50002 PROSITE
T_SNARE PS50192 PROSITE
PTHR10460 PTHR10460 PANTHER
PTHR10460:SF0 PTHR10460:SF0 PANTHER
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SH3_Abi2 cd11972 CDD