Protein: P61978 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P61978 (Uniprot)	HNRPK_HUMAN	HNRNPK	Heterogeneous nuclear ribonucleoprotein K	human	No

Protein Function

Uniprot: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, act more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	294, 353	GO:0019538	protein metabolic process	379	1.88e-02	4.66e-37
GO:0019538	protein metabolic process	379	GO:0016070	RNA metabolic process	715	5.15e-08	2.82e-13

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
31	GO:0034645	cellular macromolecule biosynthetic process
31	GO:0044271	cellular nitrogen compound biosynthetic process
31	GO:0090304	nucleic acid metabolic process
31	GO:0010468	regulation of gene expression
47	GO:0044271	cellular nitrogen compound biosynthetic process
47	GO:0051252	regulation of RNA metabolic process
47	GO:0010468	regulation of gene expression
70	GO:0051252	regulation of RNA metabolic process
70	GO:0010468	regulation of gene expression
70	GO:0006351	transcription, DNA-templated

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
31	GO:0005634	nucleus
47	GO:0005654	nucleoplasm
70	GO:0005654	nucleoplasm
80	GO:0005634	nucleus
127	GO:0005634	nucleus
160	GO:0005634	nucleus
180	GO:0005829	cytosol
180	GO:0070013	intracellular organelle lumen
180	GO:0044428	nuclear part
191	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0006396	RNA processing	TAS
GO:0007165	signal transduction	TAS
GO:0010988	regulation of low-density lipoprotein particle clearance	IMP
GO:0016032	viral process	IEA
GO:0016070	RNA metabolic process	TAS
GO:0043066	negative regulation of apoptotic process	IMP
GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process	IMP
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000790	nuclear chromatin	IDA
GO:0002102	podosome	IEA
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IEA
GO:0005925	focal adhesion	IDA
GO:0016020	membrane	IDA
GO:0031012	extracellular matrix	IDA
GO:0042995	cell projection	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000790	nuclear chromatin	GO:0005737	cytoplasm	4.55e-08	5.17e-23
GO:0000790	nuclear chromatin	GO:0016020	membrane	3.99e-39	3.29e-131
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0031012	extracellular matrix	1.58e-13	4.18e-03
GO:0005634	nucleus	GO:0042995	cell projection	1.26e-06	3.17e-18
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0005654	nucleoplasm	GO:0031012	extracellular matrix	2.78e-09	4.74e-33
GO:0005654	nucleoplasm	GO:0042995	cell projection	1.49e-18	8.51e-113
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A024R857_HUMAN	No
ABC3C_HUMAN	No
ABEC1_HUMAN	No
ABI1_HUMAN	No
ABI2_HUMAN	Yes: Q9NYB9 (MoonDB)
AES_HUMAN	Yes: Q08117 (MoonDB)
ANM1_HUMAN	No
ANR28_HUMAN	No
AQP5_HUMAN	No
AURKA_HUMAN	No

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Publications Associated

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PMID	Article Title
1729596	Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.
8107114	Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing.
9651361	Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K.
10369774	High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor.
11840567	Cluster analysis of an extensive human breast cancer cell line protein expression map database.
11991638	Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
12093748	Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA.
12183465	An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164053	DNA sequence and analysis of human chromosome 9.

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OMIM Diseases Associated

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OMIM ID	Disease Name
616580	Au-Kline syndrome

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Protein Domains Associated

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Domain Name	Domain ID	Source
hnRNP_K	IPR033090	InterPro
KH	SM00322	SMART
KH_1	PF00013	Pfam
KH_dom	IPR004087	InterPro
KH_dom_type_1	IPR004088	InterPro
KH_dom_type_1_sf	IPR036612	InterPro
KH_TYPE_1	PS50084	PROSITE
PTHR10288:SF221	PTHR10288:SF221	PANTHER
ROK_N	IPR012987	InterPro
ROKNT	PF08067	Pfam

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