Protein: P11940

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P11940 (Uniprot) PABP1_HUMAN PABPC1 Polyadenylate-binding protein 1 human No
Uniprot: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 175 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
294 GO:0000398 mRNA splicing, via spliceosome
504 GO:0044271 cellular nitrogen compound biosynthetic process
504 GO:0044267 cellular protein metabolic process
504 GO:0031324 negative regulation of cellular metabolic process
504 GO:0010629 negative regulation of gene expression
504 GO:0051172 negative regulation of nitrogen compound metabolic process
504 GO:0051252 regulation of RNA metabolic process
504 GO:2000112 regulation of cellular macromolecule biosynthetic process
798 GO:0016070 RNA metabolic process
798 GO:0010467 gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
175 GO:0005829 cytosol
175 GO:0005634 nucleus
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
437 GO:0005829 cytosol
437 GO:0031982 vesicle
504 GO:0005654 nucleoplasm
798 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
GO:0000398 mRNA splicing, via spliceosome IC
GO:0006378 mRNA polyadenylation TAS
GO:0006413 translational initiation TAS
GO:0031047 gene silencing by RNA ISS
GO:0043488 regulation of mRNA stability TAS
GO:0045070 positive regulation of viral genome replication IMP
GO:0045727 positive regulation of translation IEA
GO:0048255 mRNA stabilization TAS
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm TAS
GO:0005829 cytosol TAS
GO:0005925 focal adhesion IDA
GO:0010494 cytoplasmic stress granule IDA
GO:0016020 membrane IDA
GO:0030529 intracellular ribonucleoprotein complex IDA
GO:0036464 cytoplasmic ribonucleoprotein granule IDA
GO:0070062 extracellular exosome IDA
GO:0071013 catalytic step 2 spliceosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
2885805 Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif.
7908267 The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity.
9548260 Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
9582337 The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm.
10499800 Recognition of polyadenylate RNA by the poly(A)-binding protein.
11051545 A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.
11172725 Translational repression by a novel partner of human poly(A) binding protein, Paip2.
11287632 Structure and function of the C-terminal PABC domain of human poly(A)-binding protein.
11438674 Dual interactions of the translational repressor Paip2 with poly(A) binding protein.
11850402 PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
11997512 Paip1 interacts with poly(A) binding protein through two independent binding motifs.
12565831 Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.
15314026 UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16356927 The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex.
16421571 DNA sequence and analysis of human chromosome 8.
16804161 Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.
17212783 IMP1 interacts with poly(A)-binding protein (PABP) and the autoregulatory translational control element of PABP-mRNA through the KH III-IV domain.
17267499 NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells.
17289661 Molecular composition of IMP1 ribonucleoprotein granules.
17932509 Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
18447585 A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.
18669648 A quantitative atlas of mitotic phosphorylation.
18799579 Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.
19029303 Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20096703 Molecular determinants of PAM2 recognition by the MLLE domain of poly(A)-binding protein.
20102337 Poly(A)-binding protein (PABP): a common viral target.
20133758 Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1.
20430826 The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.
20573744 A stimulatory role for the La-related protein 4B in translation.
21098120 La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.
21269460 Initial characterization of the human central proteome.
21700224 Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
23125361 The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24532714 Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation.
25480299 Uridylation by TUT4 and TUT7 marks mRNA for degradation.
25940091 La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1).
25944712 N-terminome analysis of the human mitochondrial proteome.
26735137 Characterization of RyDEN (C19orf66) as an interferon-stimulated cellular inhibitor against dengue virus replication.
27871484 Identification of a nuclear exosome decay pathway for processed transcripts.
No results found.
Domain Name Domain ID Source
DNHUPA A93668 PIR
RRM_dom IPR000504 InterPro
PABP_HYD IPR002004 InterPro
RRM_dom_euk IPR003954 InterPro
PABP_1234 IPR006515 InterPro
RBD_domain_sf IPR035979 InterPro
PABP-dom IPR036053 InterPro
RRM_1 PF00076 Pfam
PABP PF00658 Pfam
RRM PS50102 PROSITE
PABC PS51309 PROSITE
S52491 S52491 PIR
RRM SM00360 SMART
RRM_1 SM00361 SMART
PolyA SM00517 SMART
SSF54928 SSF54928 SUPFAM
SSF63570 SSF63570 SUPFAM
PABP-1234 TIGR01628 TIGRFAMs