Protein: P11940 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P11940 (Uniprot)	PABP1_HUMAN	PABPC1	Polyadenylate-binding protein 1	human	No

Protein Function

Uniprot: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA se more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	175	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	294	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
175	GO:0044267	cellular protein metabolic process
175	GO:0006139	nucleobase-containing compound metabolic process
175	GO:0010468	regulation of gene expression
294	GO:0000398	mRNA splicing, via spliceosome
504	GO:0044271	cellular nitrogen compound biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
175	GO:0005829	cytosol
175	GO:0005634	nucleus
294	GO:0030529	intracellular ribonucleoprotein complex
294	GO:0005654	nucleoplasm
437	GO:0005829	cytosol
437	GO:0031982	vesicle
504	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	TAS
GO:0000398	mRNA splicing, via spliceosome	IC
GO:0006378	mRNA polyadenylation	TAS
GO:0006413	translational initiation	TAS
GO:0031047	gene silencing by RNA	ISS
GO:0043488	regulation of mRNA stability	TAS
GO:0045070	positive regulation of viral genome replication	IMP
GO:0045727	positive regulation of translation	IEA
GO:0048255	mRNA stabilization	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	TAS
GO:0005829	cytosol	TAS
GO:0005925	focal adhesion	IDA
GO:0010494	cytoplasmic stress granule	IDA
GO:0016020	membrane	IDA
GO:0030529	intracellular ribonucleoprotein complex	IDA
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA
GO:0070062	extracellular exosome	IDA
GO:0071013	catalytic step 2 spliceosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
APC5_HUMAN	No
ATX2_HUMAN	No
BRCA1_HUMAN	No
ERF3A_HUMAN	No
ERF3B_HUMAN	No
HNRPK_HUMAN	Yes: P61978 (MoonDB)
IF4G1_HUMAN	No
PAI2B_HUMAN	No
PAIP1_HUMAN	No
PAIP2_HUMAN	Yes: Q9BPZ3 (MoonDB)

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Publications Associated

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PMID	Article Title
2885805	Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif.
7908267	The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity.
9548260	Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.
9582337	The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm.
10499800	Recognition of polyadenylate RNA by the poly(A)-binding protein.
11051545	A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.
11172725	Translational repression by a novel partner of human poly(A) binding protein, Paip2.
11287632	Structure and function of the C-terminal PABC domain of human poly(A)-binding protein.
11438674	Dual interactions of the translational repressor Paip2 with poly(A) binding protein.
11850402	PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
DNHUPA	A93668	PIR
PABC	PS51309	PROSITE
PABP	PF00658	Pfam
PABP-1234	TIGR01628	TIGRFAMs
PABP-dom	IPR036053	InterPro
PABP_1234	IPR006515	InterPro
PABP_HYD	IPR002004	InterPro
PolyA	SM00517	SMART
RBD_domain_sf	IPR035979	InterPro
RRM	PS50102	PROSITE

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