Protein: Q9BPZ3 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9BPZ3 (Uniprot)	PAIP2_HUMAN	PAIP2	Polyadenylate-binding protein-interacting protein 2	human	No

Protein Function

Uniprot: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disru more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187	GO:0034641	cellular nitrogen compound metabolic process	504	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
187	GO:0007166	cell surface receptor signaling pathway
187	GO:0006464	cellular protein modification process
187	GO:0070887	cellular response to chemical stimulus
187	GO:0035556	intracellular signal transduction
187	GO:0006928	movement of cell or subcellular component
187	GO:0006796	phosphate-containing compound metabolic process
187	GO:0010647	positive regulation of cell communication
187	GO:0048584	positive regulation of response to stimulus
187	GO:0023056	positive regulation of signaling
187	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane
504	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007283	spermatogenesis	IEA
GO:0007613	memory	IEA
GO:0045947	negative regulation of translational initiation	IDA
GO:1900271	regulation of long-term synaptic potentiation	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
PABP1_HUMAN	Yes: P11940 (MoonDB)
PABP5_HUMAN	No
RL11_HUMAN	No
UBR5_HUMAN	No

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Publications Associated

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PMID	Article Title
11042152	Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
11172725	Translational repression by a novel partner of human poly(A) binding protein, Paip2.
11230166	Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11287632	Structure and function of the C-terminal PABC domain of human poly(A)-binding protein.
11438674	Dual interactions of the translational repressor Paip2 with poly(A) binding protein.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16804161	Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Ataxin-2_C	IPR009818	InterPro
PAM2	PF07145	Pfam

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