Protein: Q9BWF3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9BWF3 (Uniprot) RBM4_HUMAN RBM4 RNA-binding protein 4 human No
Uniprot: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006396 RNA processing 426 GO:0036211 protein modification process 440 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
294 GO:0000398 mRNA splicing, via spliceosome
334 GO:0016070 RNA metabolic process
334 GO:0010467 gene expression
334 GO:0060255 regulation of macromolecule metabolic process
403 GO:0060255 regulation of macromolecule metabolic process
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
834 GO:0051252 regulation of RNA metabolic process
834 GO:2000112 regulation of cellular macromolecule biosynthetic process
834 GO:0010468 regulation of gene expression
834 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
64 GO:0005634 nucleus
191 GO:0031981 nuclear lumen
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
334 GO:0031981 nuclear lumen
403 GO:0005634 nucleus
426 GO:0005654 nucleoplasm
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
467 GO:0005654 nucleoplasm
834 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA
GO:0002190 cap-independent translational initiation IDA
GO:0002192 IRES-dependent translational initiation of linear mRNA IDA
GO:0006396 RNA processing TAS
GO:0006397 mRNA processing IEA
GO:0008380 RNA splicing IEA
GO:0017148 negative regulation of translation IDA
GO:0030154 cell differentiation IEA
GO:0032055 negative regulation of translation in response to stress IDA
GO:0035278 miRNA mediated inhibition of translation IDA
GO:0043153 entrainment of circadian clock by photoperiod ISS
GO:0045947 negative regulation of translational initiation IDA
GO:0046685 response to arsenic-containing substance IDA
GO:0046822 regulation of nucleocytoplasmic transport IDA
GO:0051149 positive regulation of muscle cell differentiation IDA
GO:0097167 circadian regulation of translation ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0010494 cytoplasmic stress granule IDA
GO:0016607 nuclear speck IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9169144 A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans.
12469345 Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.
12628928 A novel splicing regulator shares a nuclear import pathway with SR proteins.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16260624 Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16777844 RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.
16907643 Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties.
16934801 WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17284590 Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.
17932509 Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18708123 The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.
19561594 Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins.
19801630 RNA-binding motif protein 4 translocates to cytoplasmic granules and suppresses translation via argonaute2 during muscle cell differentiation.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21343338 RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21518792 RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
RRM_dom IPR000504 InterPro
Znf_CCHC IPR001878 InterPro
RBM4_RRM1 IPR034897 InterPro
RBM4_RRM2 IPR034898 InterPro
RBD_domain_sf IPR035979 InterPro
Znf_CCHC_sf IPR036875 InterPro
RRM_1 PF00076 Pfam
zf-CCHC PF00098 Pfam
RRM PS50102 PROSITE
ZF_CCHC PS50158 PROSITE
ZnF_C2HC SM00343 SMART
RRM SM00360 SMART
SSF54928 SSF54928 SUPFAM
RRM1_RBM4 cd12606 CDD
RRM2_RBM4 cd12607 CDD