Protein: Q9BWF3 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9BWF3 (Uniprot)	RBM4_HUMAN	RBM4	RNA-binding protein 4	human	No

Protein Function

Uniprot: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell di more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006396	RNA processing	426	GO:0036211	protein modification process	440	5.60e-03	3.14e-16

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 32 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
64	GO:0016070	RNA metabolic process
64	GO:0010467	gene expression
64	GO:0060255	regulation of macromolecule metabolic process
191	GO:0006355	regulation of transcription, DNA-templated
294	GO:0000398	mRNA splicing, via spliceosome
334	GO:0016070	RNA metabolic process
334	GO:0010467	gene expression
334	GO:0060255	regulation of macromolecule metabolic process
403	GO:0060255	regulation of macromolecule metabolic process
426	GO:0008380	RNA splicing

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
64	GO:0005634	nucleus
191	GO:0031981	nuclear lumen
294	GO:0030529	intracellular ribonucleoprotein complex
294	GO:0005654	nucleoplasm
334	GO:0031981	nuclear lumen
403	GO:0005634	nucleus
426	GO:0005654	nucleoplasm
440	GO:0005829	cytosol
440	GO:0005634	nucleus
440	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	IDA
GO:0002190	cap-independent translational initiation	IDA
GO:0002192	IRES-dependent translational initiation of linear mRNA	IDA
GO:0006396	RNA processing	TAS
GO:0006397	mRNA processing	IEA
GO:0008380	RNA splicing	IEA
GO:0017148	negative regulation of translation	IDA
GO:0030154	cell differentiation	IEA
GO:0032055	negative regulation of translation in response to stress	IDA
GO:0035278	miRNA mediated inhibition of translation	IDA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA
GO:0010494	cytoplasmic stress granule	IDA
GO:0016607	nuclear speck	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 28 entries

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Interactor	Also a MoonDB EMF protein
AQR_HUMAN	No
CCNA1_HUMAN	No
CX056_HUMAN	No
DDX17_HUMAN	No
DDX5_HUMAN	No
DGC14_HUMAN	No
DHX9_HUMAN	No
HNRH2_HUMAN	No
HNRH3_HUMAN	No
HNRL1_HUMAN	No

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Publications Associated

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PMID	Article Title
9169144	A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans.
12469345	Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.
12628928	A novel splicing regulator shares a nuclear import pathway with SR proteins.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16260624	Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB.
16554811	Human chromosome 11 DNA sequence and analysis including novel gene identification.
16777844	RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.
16907643	Lark is the splicing factor RBM4 and exhibits unique subnuclear localization properties.
16934801	WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 15 entries

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Domain Name	Domain ID	Source
RBD_domain_sf	IPR035979	InterPro
RBM4_RRM1	IPR034897	InterPro
RBM4_RRM2	IPR034898	InterPro
RRM	PS50102	PROSITE
RRM	SM00360	SMART
RRM1_RBM4	cd12606	CDD
RRM2_RBM4	cd12607	CDD
RRM_1	PF00076	Pfam
RRM_dom	IPR000504	InterPro
SSF54928	SSF54928	SUPFAM

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