Protein: P12931

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P12931 (Uniprot) SRC_HUMAN SRC Proto-oncogene tyrosine-protein kinase Src human No
Uniprot: Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) (PubMed:21411625). In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 (PubMed:11389730). Plays a role in EGF-mediated calcium-activated chloride channel activation (PubMed:18586953). Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus (PubMed:7853507). Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function (PubMed:8755529, PubMed:14585963). Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase (PubMed:12615910). Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation (PubMed:16186108). Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' (PubMed:20100835, PubMed:21309750). Enhances DDX58/RIG-I-elicited antiviral signaling (PubMed:19419966). Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' (PubMed:14585963). Phosphorylates BCAR1 at 'Tyr-128' (PubMed:22710723). Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity (PubMed:20525694). Involved in anchorage-independent cell growth (PubMed:19307596). Required for podosome formation (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 180, 327 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 173, 682 2.49e-18 9.18e-29
GO:0034641 cellular nitrogen compound metabolic process 180 GO:0007165 signal transduction 187 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 180 GO:0010646 regulation of cell communication 284 1.59e-39 2.52e-03
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
29 GO:0060255 regulation of macromolecule metabolic process
29 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
173 GO:0034645 cellular macromolecule biosynthetic process
173 GO:0006464 cellular protein modification process
173 GO:0010467 gene expression
173 GO:0035556 intracellular signal transduction
173 GO:0090304 nucleic acid metabolic process
173 GO:0016310 phosphorylation
173 GO:0031325 positive regulation of cellular metabolic process
173 GO:0010604 positive regulation of macromolecule metabolic process
173 GO:0051173 positive regulation of nitrogen compound metabolic process
173 GO:0031326 regulation of cellular biosynthetic process
173 GO:0019219 regulation of nucleobase-containing compound metabolic process
177 GO:0044267 cellular protein metabolic process
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
259 GO:0007165 signal transduction
274 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
573 GO:0006464 cellular protein modification process
573 GO:0006139 nucleobase-containing compound metabolic process
573 GO:0060255 regulation of macromolecule metabolic process
573 GO:0007165 signal transduction
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
617 GO:0007165 signal transduction
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
867 GO:0044267 cellular protein metabolic process
867 GO:0071495 cellular response to endogenous stimulus
867 GO:0071310 cellular response to organic substance
867 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
867 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
29 GO:0005634 nucleus
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
173 GO:0005654 nucleoplasm
177 GO:0005634 nucleus
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
254 GO:0005829 cytosol
254 GO:0005634 nucleus
259 GO:0005886 plasma membrane
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
488 GO:0005634 nucleus
488 GO:0031982 vesicle
573 GO:0005829 cytosol
573 GO:0012505 endomembrane system
573 GO:0070013 intracellular organelle lumen
573 GO:0044428 nuclear part
573 GO:0031982 vesicle
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
678 GO:0043232 intracellular non-membrane-bounded organelle
682 GO:0005634 nucleus
867 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001545 primary ovarian follicle growth IEA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0007049 cell cycle IEA
GO:0007165 signal transduction TAS
GO:0007172 signal complex assembly TAS
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007179 transforming growth factor beta receptor signaling pathway IMP
GO:0007229 integrin-mediated signaling pathway IMP
GO:0007411 axon guidance TAS
GO:0007417 central nervous system development IBA
GO:0008283 cell proliferation IEA
GO:0009612 response to mechanical stimulus IEA
GO:0009615 response to virus IEA
GO:0010447 response to acidic pH IEA
GO:0010632 regulation of epithelial cell migration IMP
GO:0010634 positive regulation of epithelial cell migration IMP
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA
GO:0010907 positive regulation of glucose metabolic process IEA
GO:0010954 positive regulation of protein processing IEA
GO:0014911 positive regulation of smooth muscle cell migration IEA
GO:0016032 viral process IEA
GO:0016236 macroautophagy TAS
GO:0018105 peptidyl-serine phosphorylation IEA
GO:0018108 peptidyl-tyrosine phosphorylation IMP
GO:0022407 regulation of cell-cell adhesion IMP
GO:0030168 platelet activation TAS
GO:0030520 intracellular estrogen receptor signaling pathway IBA
GO:0030900 forebrain development IEA
GO:0031295 T cell costimulation TAS
GO:0031648 protein destabilization IEA
GO:0031667 response to nutrient levels IEA
GO:0031954 positive regulation of protein autophosphorylation IEA
GO:0032148 activation of protein kinase B activity IEA
GO:0032211 negative regulation of telomere maintenance via telomerase IMP
GO:0032463 negative regulation of protein homooligomerization IMP
GO:0032869 cellular response to insulin stimulus IEA
GO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA
GO:0033625 positive regulation of integrin activation TAS
GO:0034332 adherens junction organization IEA
GO:0034446 substrate adhesion-dependent cell spreading IEA
GO:0034614 cellular response to reactive oxygen species IEA
GO:0035556 intracellular signal transduction IDA
GO:0035635 entry of bacterium into host cell TAS
GO:0036035 osteoclast development IBA
GO:0036120 cellular response to platelet-derived growth factor stimulus IEA
GO:0038083 peptidyl-tyrosine autophosphorylation IBA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042127 regulation of cell proliferation IBA
GO:0042493 response to drug IEA
GO:0042542 response to hydrogen peroxide IEA
GO:0043065 positive regulation of apoptotic process IEA
GO:0043066 negative regulation of apoptotic process IMP
GO:0043114 regulation of vascular permeability TAS
GO:0043149 stress fiber assembly IMP
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
GO:0043393 regulation of protein binding IEA
GO:0043406 positive regulation of MAP kinase activity IEA
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
GO:0045056 transcytosis IEA
GO:0045087 innate immune response IBA
GO:0045124 regulation of bone resorption TAS
GO:0045453 bone resorption ISS
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0045892 negative regulation of transcription, DNA-templated IEA
GO:0045893 positive regulation of transcription, DNA-templated IEA
GO:0046628 positive regulation of insulin receptor signaling pathway IEA
GO:0046777 protein autophosphorylation IDA
GO:0048008 platelet-derived growth factor receptor signaling pathway IBA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048011 neurotrophin TRK receptor signaling pathway IEA
GO:0048013 ephrin receptor signaling pathway TAS
GO:0048477 oogenesis IEA
GO:0050715 positive regulation of cytokine secretion IEA
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IC
GO:0050847 progesterone receptor signaling pathway IBA
GO:0050900 leukocyte migration TAS
GO:0051057 positive regulation of small GTPase mediated signal transduction IMP
GO:0051385 response to mineralocorticoid IEA
GO:0051602 response to electrical stimulus IEA
GO:0051726 regulation of cell cycle IBA
GO:0051895 negative regulation of focal adhesion assembly ISS
GO:0051897 positive regulation of protein kinase B signaling IMP
GO:0051902 negative regulation of mitochondrial depolarization IMP
GO:0051974 negative regulation of telomerase activity IMP
GO:0060065 uterus development IEA
GO:0060444 branching involved in mammary gland duct morphogenesis IEA
GO:0060491 regulation of cell projection assembly IEA
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
GO:0070555 response to interleukin-1 IMP
GO:0071222 cellular response to lipopolysaccharide IEA
GO:0071375 cellular response to peptide hormone stimulus ISS
GO:0071393 cellular response to progesterone stimulus ISS
GO:0071398 cellular response to fatty acid IEA
GO:0071456 cellular response to hypoxia IEA
GO:0071498 cellular response to fluid shear stress IEA
GO:0071801 regulation of podosome assembly IBA
GO:0071803 positive regulation of podosome assembly IEA
GO:0071902 positive regulation of protein serine/threonine kinase activity IDA
GO:0086098 angiotensin-activated signaling pathway involved in heart process ISS
GO:0090263 positive regulation of canonical Wnt signaling pathway IEA
GO:0098609 cell-cell adhesion IEA
GO:1900182 positive regulation of protein localization to nucleus IEA
GO:2000386 positive regulation of ovarian follicle development IEA
GO:2000394 positive regulation of lamellipodium morphogenesis IMP
GO:2000573 positive regulation of DNA biosynthetic process IEA
GO:2000641 regulation of early endosome to late endosome transport IMP
GO:2000811 negative regulation of anoikis IMP
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP
GO:2001286 regulation of caveolin-mediated endocytosis IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0002102 podosome IEA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IDA
GO:0005743 mitochondrial inner membrane IDA
GO:0005764 lysosome IDA
GO:0005770 late endosome IDA
GO:0005829 cytosol TAS
GO:0005884 actin filament IEA
GO:0005886 plasma membrane TAS
GO:0005901 caveola IDA
GO:0014069 postsynaptic density IEA
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
GO:0032587 ruffle membrane IEA
GO:0043005 neuron projection IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0005743 mitochondrial inner membrane 5.37e-05 2.97e-03
GO:0005654 nucleoplasm GO:0005764 lysosome 2.37e-10 6.13e-13
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
GO:0005743 mitochondrial inner membrane GO:0005829 cytosol 6.20e-17 9.93e-03
Interactor Also a MoonDB EMF protein
TRIP6_HUMAN No
P55G_HUMAN Yes: Q92569 (MoonDB)
ADA15_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
TNFL6_HUMAN No
HXC8_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
EIF3D_HUMAN No
AIRE_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
ESR2_HUMAN Yes: Q92731 (MoonDB)
DLGP2_HUMAN No
HNRPK_HUMAN Yes: P61978 (MoonDB)
AKT1_HUMAN No
CBLC_HUMAN No
RACK1_HUMAN No
FAK1_HUMAN No
TAU_HUMAN No
PRIC3_HUMAN No
AL2SB_HUMAN No
DPYL1_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
ABL1_HUMAN Yes: P00519 (MoonDB)
PAR3_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
ACAP1_HUMAN No
ADRB2_HUMAN Yes: P07550 (MoonDB)
AFAD_HUMAN No
AKAP2_HUMAN No
AKAP6_HUMAN No
ALDOB_HUMAN Yes: P05062 (MoonDB)
ANDR_HUMAN Yes: P10275 (MoonDB)
APOL5_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
ASB16_HUMAN No
BAAT_HUMAN No
BCAR1_HUMAN No
BICRA_HUMAN No
CAH3_HUMAN No
CATL2_HUMAN No
CBLB_HUMAN No
CBL_HUMAN No
CC180_HUMAN No
CCNA1_HUMAN No
CD97_HUMAN No
CDN1B_HUMAN Yes: P46527 (MoonDB)
CELR2_HUMAN No
CKAP5_HUMAN No
CP4F2_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
CUL9_HUMAN No
DAG1_HUMAN No
DLGP1_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX4_HUMAN No
DNLI3_HUMAN No
DOCK1_HUMAN No
DOCK3_HUMAN No
DPOD1_HUMAN No
DUS15_HUMAN No
DYN1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
E41L3_HUMAN No
EFS_HUMAN No
EPHB2_HUMAN No
ERBB3_HUMAN Yes: P21860 (MoonDB)
ESR1_HUMAN Yes: P03372 (MoonDB)
ETS1_HUMAN Yes: P14921 (MoonDB)
EXTL3_HUMAN No
F16P2_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FANCC_HUMAN No
FCG2B_HUMAN No
FCG2C_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GLT12_HUMAN No
GNS_HUMAN No
HCN2_HUMAN No
HEMGN_HUMAN No
I20L2_HUMAN No
ICAL_HUMAN No
ID4_HUMAN No
KHDR1_HUMAN No
KI67_HUMAN No
KIT_HUMAN No
LPH_HUMAN No
M4K1_HUMAN No
MAPK3_HUMAN No
MED28_HUMAN No
MEPE_HUMAN No
MET_HUMAN No
MIME_HUMAN No
MP2K1_HUMAN No
NCOA6_HUMAN No
NKX21_HUMAN No
NR1I3_HUMAN No
NU2M_HUMAN No
NXPH3_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
PAK2_HUMAN No
PAX3_HUMAN No
PAX7_HUMAN No
PDE4D_HUMAN No
PDIA2_HUMAN No
PECA1_HUMAN No
PHAR2_HUMAN No
PP2AB_HUMAN No
PRGR_HUMAN No
PSB9_HUMAN No
PTN11_HUMAN Yes: Q06124 (MoonDB)
PTN1_HUMAN No
PTN23_HUMAN No
RARA_HUMAN Yes: P10276 (MoonDB)
RL13_HUMAN No
RLGPB_HUMAN No
ROR1_HUMAN No
RORA_HUMAN No
RPGF1_HUMAN No
RPP38_HUMAN No
RRAS_HUMAN No
RTN4_HUMAN No
RUNX3_HUMAN No
SELN_HUMAN No
SHAN2_HUMAN No
SHAN3_HUMAN No
SHRM2_HUMAN No
SIAS_HUMAN No
SNX17_HUMAN No
SNX3_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
SP1_HUMAN No
SPR2A_HUMAN No
STX17_HUMAN No
TENS3_HUMAN No
TRI15_HUMAN Yes: Q9C019 (MoonDB)
TRMO_HUMAN No
TULP4_HUMAN No
TXNIP_HUMAN No
UFO_HUMAN No
VDR_HUMAN Yes: P11473 (MoonDB)
VILI_HUMAN No
XPA_HUMAN No
ZN189_HUMAN No
ZP2_HUMAN No
PMID Article Title
1691439 Identification of a novel neuronal C-SRC exon expressed in human brain.
2498394 pp60c-src activation in human colon carcinoma.
2581127 Isolation of duplicated human c-src genes located on chromosomes 1 and 20.
2582238 Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-src.
2681803 Neuron-specific splicing of C-SRC RNA in human brain.
3093483 Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.
3299057 DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.
6273838 Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).
7478590 Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas.
7525268 Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.
7532003 Solution structure of the human pp60c-src SH2 domain complexed with a phosphorylated tyrosine pentapeptide.
7853507 Highly specific antibody to Rous sarcoma virus src gene product recognizes nuclear and nucleolar antigens in human cells.
7929427 Cdc2-mediated modulation of pp60c-src activity.
8672527 Regulation, substrates and functions of src.
8755529 Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro.
8759729 Physical and functional association of Fc mu receptor on human natural killer cells with the zeta- and Fc epsilon RI gamma-chains and with src family protein tyrosine kinases.
9024657 Three-dimensional structure of the tyrosine kinase c-Src.
9174343 Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
9442882 Cellular functions regulated by Src family kinases.
9571170 Butein, a specific protein tyrosine kinase inhibitor.
9584165 RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.
9924018 Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
10747847 Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.
10753943 beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
11152665 The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin.
11279199 The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1.
11389730 Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm.
11518702 The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
11964124 Novel regulation and function of Src tyrosine kinase.
12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.
12415108 Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
12615910 Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.
12925710 EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
14585963 Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.
14632929 Development and characterization of potent and specific peptide inhibitors of p60c-src protein tyrosine kinase using pseudosubstrate-based inhibitor design approach.
14661060 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15504032 Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
15851033 The C2 domain of PKCdelta is a phosphotyrosine binding domain.
16186108 Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation.
16479011 The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors.
17202804 Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5.
17293535 Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation.
17344846 Patterns of somatic mutation in human cancer genomes.
17525734 p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.
18024423 Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.
18088087 Phosphoproteome of resting human platelets.
18586953 EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.
18657504 Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18936167 New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.
19307596 Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle.
19369195 Large-scale proteomics analysis of the human kinome.
19419966 The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
19665017 The PDZ protein MPP2 interacts with c-Src in epithelial cells.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
20100835 Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
20525694 The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.
20534535 Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
21036157 Heme controls the regulation of protein tyrosine kinases Jak2 and Src.
21309750 The Cdc42-associated kinase ACK1 is not auto-inhibited but requires Src for activation.
21411625 A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src.
21442427 Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src(S75).
21460222 PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis.
22710723 Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
22888118 Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23564345 Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
26936507 A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.
OMIM ID Disease Name
616937 Thrombocytopenia 6
Domain Name Domain ID Source
TVHUSC A26891 PIR
Prot_kinase_dom IPR000719 InterPro
SH2 IPR000980 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
SH3_domain IPR001452 InterPro
Tyr_kinase_AS IPR008266 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
Pkinase_Tyr PF07714 Pfam
TYRKINASE PR00109 PRINTS
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_TYR PS00109 PROSITE
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
TyrKc SM00219 SMART
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SSF56112 SSF56112 SUPFAM