Protein: P27986

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P27986 (Uniprot) P85A_HUMAN PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha human No
Uniprot: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 20, 118, 253, 310 GO:0033036 macromolecule localization 517 2.48e-08 1.95e-27
GO:0043170 macromolecule metabolic process 20, 118, 253, 310 GO:0022610 biological adhesion 869 2.68e-16 4.92e-03
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0007165 signal transduction 355, 486 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0033036 macromolecule localization 517 4.14e-25 1.17e-53
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
GO:0044260 cellular macromolecule metabolic process 100, 589 GO:0033036 macromolecule localization 517 4.56e-06 3.25e-28
GO:0044260 cellular macromolecule metabolic process 100, 589 GO:0022610 biological adhesion 869 6.74e-23 3.02e-10
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 698 6.88e-41 1.21e-84
GO:0007165 signal transduction 187, 282, 355, 486 GO:0006139 nucleobase-containing compound metabolic process 698 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35, 327 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 698 6.71e-28 7.52e-07
GO:0006928 movement of cell or subcellular component 496 GO:0006139 nucleobase-containing compound metabolic process 698 1.95e-31 6.36e-195
GO:0033036 macromolecule localization 517 GO:0006139 nucleobase-containing compound metabolic process 698 4.58e-19 9.70e-72
GO:0006139 nucleobase-containing compound metabolic process 698 GO:0022610 biological adhesion 869 2.30e-55 4.36e-110
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
100 GO:0016070 RNA metabolic process
100 GO:0034645 cellular macromolecule biosynthetic process
100 GO:0044271 cellular nitrogen compound biosynthetic process
100 GO:0010468 regulation of gene expression
100 GO:0019219 regulation of nucleobase-containing compound metabolic process
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
118 GO:0019538 protein metabolic process
118 GO:0060255 regulation of macromolecule metabolic process
118 GO:0007165 signal transduction
171 GO:0006464 cellular protein modification process
171 GO:0035556 intracellular signal transduction
171 GO:0009966 regulation of signal transduction
177 GO:0044267 cellular protein metabolic process
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
253 GO:0019538 protein metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
259 GO:0007165 signal transduction
274 GO:0007165 signal transduction
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
284 GO:0009966 regulation of signal transduction
304 GO:0044267 cellular protein metabolic process
304 GO:0007165 signal transduction
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
310 GO:0019538 protein metabolic process
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
409 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
514 GO:0044267 cellular protein metabolic process
514 GO:0071310 cellular response to organic substance
514 GO:0033554 cellular response to stress
514 GO:0035556 intracellular signal transduction
514 GO:0031328 positive regulation of cellular biosynthetic process
514 GO:0010557 positive regulation of macromolecule biosynthetic process
514 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
514 GO:0042981 regulation of apoptotic process
514 GO:0010646 regulation of cell communication
514 GO:0023051 regulation of signaling
514 GO:0006357 regulation of transcription from RNA polymerase II promoter
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
589 GO:0016070 RNA metabolic process
589 GO:0010467 gene expression
589 GO:0031325 positive regulation of cellular metabolic process
589 GO:2000112 regulation of cellular macromolecule biosynthetic process
589 GO:0019219 regulation of nucleobase-containing compound metabolic process
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
645 GO:0060255 regulation of macromolecule metabolic process
688 GO:0006355 regulation of transcription, DNA-templated
688 GO:0007165 signal transduction
698 GO:0090304 nucleic acid metabolic process
698 GO:0010646 regulation of cell communication
698 GO:0060255 regulation of macromolecule metabolic process
698 GO:0023051 regulation of signaling
698 GO:0007165 signal transduction
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
30 GO:0005829 cytosol
30 GO:0043232 intracellular non-membrane-bounded organelle
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
100 GO:0005829 cytosol
100 GO:0005634 nucleus
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
171 GO:0005829 cytosol
171 GO:0005886 plasma membrane
177 GO:0005634 nucleus
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
254 GO:0005829 cytosol
254 GO:0005634 nucleus
259 GO:0005886 plasma membrane
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
306 GO:0070062 extracellular exosome
310 GO:0005829 cytosol
310 GO:0005634 nucleus
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
409 GO:0005829 cytosol
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
514 GO:0005654 nucleoplasm
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
589 GO:0005829 cytosol
589 GO:0005634 nucleus
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
645 GO:0005829 cytosol
645 GO:0005634 nucleus
688 GO:0005634 nucleus
698 GO:0043232 intracellular non-membrane-bounded organelle
698 GO:0031981 nuclear lumen
698 GO:0005886 plasma membrane
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001678 cellular glucose homeostasis ISS
GO:0001953 negative regulation of cell-matrix adhesion IEA
GO:0006468 protein phosphorylation IEA
GO:0006661 phosphatidylinositol biosynthetic process TAS
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007186 G-protein coupled receptor signaling pathway TAS
GO:0007411 axon guidance TAS
GO:0008286 insulin receptor signaling pathway IBA
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
GO:0014065 phosphatidylinositol 3-kinase signaling IDA
GO:0016032 viral process IEA
GO:0030168 platelet activation TAS
GO:0030183 B cell differentiation IEA
GO:0030335 positive regulation of cell migration IEA
GO:0031295 T cell costimulation TAS
GO:0032760 positive regulation of tumor necrosis factor production IEA
GO:0032869 cellular response to insulin stimulus ISS
GO:0033120 positive regulation of RNA splicing IMP
GO:0034644 cellular response to UV IEA
GO:0034976 response to endoplasmic reticulum stress IDA
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042993 positive regulation of transcription factor import into nucleus IDA
GO:0043066 negative regulation of apoptotic process IMP
GO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA
GO:0045671 negative regulation of osteoclast differentiation IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0046326 positive regulation of glucose import ISS
GO:0046626 regulation of insulin receptor signaling pathway IEA
GO:0046854 phosphatidylinositol phosphorylation IBA
GO:0048009 insulin-like growth factor receptor signaling pathway IDA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048015 phosphatidylinositol-mediated signaling TAS
GO:0050821 protein stabilization IDA
GO:0050852 T cell receptor signaling pathway TAS
GO:0050900 leukocyte migration TAS
GO:0051492 regulation of stress fiber assembly IEA
GO:0051531 NFAT protein import into nucleus IEA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0060396 growth hormone receptor signaling pathway IDA
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IMP
GO:1903078 positive regulation of protein localization to plasma membrane ISS
GO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus ISS
GO:0005737 cytoplasm IDA
GO:0005801 cis-Golgi network IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005911 cell-cell junction IEA
GO:0005942 phosphatidylinositol 3-kinase complex IBA
GO:0005943 phosphatidylinositol 3-kinase complex, class IA ISS
GO:0016020 membrane IDA
GO:0043234 protein complex IEA
GO:1990578 perinuclear endoplasmic reticulum membrane IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
Interactor Also a MoonDB EMF protein
IKZF3_HUMAN No
HXA1_HUMAN No
BLK_HUMAN No
ZDH17_HUMAN No
TMM17_HUMAN Yes: Q86X19 (MoonDB)
IKBA_HUMAN No
FOXH1_HUMAN No
DTBP1_HUMAN No
TNFL6_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
HD_HUMAN Yes: P42858 (MoonDB)
EGFR_HUMAN Yes: P00533 (MoonDB)
SUV92_HUMAN No
SH3K1_HUMAN No
CRKL_HUMAN No
FYN_HUMAN Yes: P06241 (MoonDB)
ERBB2_HUMAN Yes: P04626 (MoonDB)
CSDC2_HUMAN No
AIRE_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
TENS4_HUMAN No
DLGP2_HUMAN No
S23A1_HUMAN No
ZC4H2_HUMAN No
TYRO3_HUMAN No
FAK1_HUMAN No
BRCA1_HUMAN No
SHC1_HUMAN No
MYRIP_HUMAN No
AL2SB_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
SRC_HUMAN Yes: P12931 (MoonDB)
CRK_HUMAN Yes: P46108 (MoonDB)
PK3CD_HUMAN No
RASH_HUMAN No
ABCG5_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
AKAP2_HUMAN No
AKAP6_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
APOL5_HUMAN No
ARAF_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
ATS2_HUMAN No
BICRA_HUMAN No
BRD4_HUMAN No
BRPF3_HUMAN No
CAF1A_HUMAN No
CBL_HUMAN No
CCL14_HUMAN No
CD28_HUMAN No
CD5_HUMAN No
CD7_HUMAN No
CDC27_HUMAN No
CKAP5_HUMAN No
CLNK_HUMAN No
CP4AB_HUMAN No
CSDE1_HUMAN No
CSF1R_HUMAN No
CSF2R_HUMAN No
CTNB1_HUMAN No
CXCL2_HUMAN No
DAB2_HUMAN No
DAG1_HUMAN No
DLGP1_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX2_HUMAN No
DLX4_HUMAN No
DNLI3_HUMAN No
DOCK3_HUMAN No
DP13A_HUMAN Yes: Q9UKG1 (MoonDB)
DUS15_HUMAN No
ECT2_HUMAN No
EF1D_HUMAN No
EFS_HUMAN No
ELK3_HUMAN No
EPHA2_HUMAN No
EPOR_HUMAN No
ERBB3_HUMAN Yes: P21860 (MoonDB)
ERF3A_HUMAN No
ESR1_HUMAN Yes: P03372 (MoonDB)
EXTL3_HUMAN No
FANCA_HUMAN Yes: O15360 (MoonDB)
FER_HUMAN No
FGFR1_HUMAN No
FLNB_HUMAN No
FLNC_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GAB2_HUMAN No
GABR1_HUMAN No
GBRA3_HUMAN No
GHR_HUMAN No
ICAL_HUMAN No
ID4_HUMAN No
IGF1R_HUMAN No
INSR_HUMAN No
IRS1_HUMAN No
IRS2_HUMAN No
ITSN1_HUMAN No
JAK2_HUMAN No
KHDR1_HUMAN No
KI13A_HUMAN No
KI2L1_HUMAN No
KIT_HUMAN No
KSYK_HUMAN Yes: P43405 (MoonDB)
LCP2_HUMAN No
LIPA3_HUMAN No
LNX2_HUMAN Yes: Q8N448 (MoonDB)
M4K1_HUMAN No
MAP4_HUMAN No
MED28_HUMAN No
MEPE_HUMAN No
MET_HUMAN No
MINT_HUMAN No
MYLK_HUMAN No
NCKX1_HUMAN No
NELFB_HUMAN No
NTRK1_HUMAN No
NTRK2_HUMAN No
P3C2B_HUMAN No
PAXI_HUMAN No
PDE4D_HUMAN No
PDIA2_HUMAN No
PEBP1_HUMAN No
PERE_HUMAN No
PGFRA_HUMAN No
PGFRB_HUMAN No
PHAR2_HUMAN No
PK3CA_HUMAN No
PK3CB_HUMAN No
PLCG2_HUMAN Yes: P16885 (MoonDB)
PTN4_HUMAN No
PTN6_HUMAN Yes: P29350 (MoonDB)
RL13_HUMAN No
RPA2_HUMAN No
RPGF1_HUMAN No
RRAS_HUMAN No
SCG2_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SHAN2_HUMAN No
SHAN3_HUMAN No
SIK2_HUMAN No
SNX17_HUMAN No
SNX8_HUMAN No
SOCS1_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
SQSTM_HUMAN Yes: Q13501 (MoonDB)
SSR2_HUMAN No
STAT3_HUMAN Yes: P40763 (MoonDB)
STF1_HUMAN No
SYDC_HUMAN No
SYNJ2_HUMAN No
TGDS_HUMAN No
TGON2_HUMAN No
TLR2_HUMAN No
TPX2_HUMAN No
TRYB1_HUMAN No
TRYB2_HUMAN No
TTHY_HUMAN No
TULP4_HUMAN No
TXK_HUMAN No
UFO_HUMAN No
VGFR1_HUMAN No
VP13A_HUMAN No
PMID Article Title
1849461 Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
7518429 Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
7537849 Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
7541045 Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
7681364 Structure of the PI3K SH3 domain and analysis of the SH3 family.
7692233 Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
8276809 Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
8599763 Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
8628286 Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
8648629 Crystal structure of P13K SH3 domain at 2.0-A resolution.
8670861 Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase.
8940081 Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.
8961927 Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
8962058 Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
9032108 Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index.
9038210 Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
9178760 Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
9489702 LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
9553137 Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.
9687533 T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.
10086340 cbl-b inhibits epidermal growth factor receptor signaling.
10528161 KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.
10739672 Clustering of beta(2)-integrins on human neutrophils activates dual signaling pathways to PtdIns 3-kinase.
10768093 Natural variants of human p85 alpha phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.
10867024 Ligand discrimination in signaling through an ErbB4 receptor homodimer.
11087752 Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.
11526404 Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.
11567151 NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.
11912194 Insulin receptor substrate 4 associates with the protein IRAS.
12009866 Interaction between Nef and phosphatidylinositol-3-kinase leads to activation of p21-activated kinase and increased production of HIV.
12186904 Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.
12359715 Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15302586 The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
15372022 The DNA sequence and comparative analysis of human chromosome 5.
15488758 TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15526160 Signal transduction via the stem cell factor receptor/c-Kit.
15561106 The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15863030 Cellular signaling by fibroblast growth factor receptors.
17626883 Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit.
18079394 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
18348712 The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase.
18721752 System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties.
19286672 A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.
19369195 Large-scale proteomics analysis of the human kinome.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19805105 A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.
19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
19919182 Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding.
20348923 A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
21228233 Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.
22351933 Agammaglobulinemia and absent B lineage cells in a patient lacking the p85? subunit of PI3K.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23192871 Varicella-zoster virus ORF12 protein activates the phosphatidylinositol 3-kinase/Akt pathway to regulate cell cycle progression.
23676467 FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies.
23810378 PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy.
23810379 SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.
23810382 Mutations in PIK3R1 cause SHORT syndrome.
25133428 A human immunodeficiency caused by mutations in the PIK3R1 gene.
25944712 N-terminome analysis of the human mitochondrial proteome.
OMIM ID Disease Name
269880 SHORT syndrome
615214 Agammaglobulinemia 7, autosomal recessive
616005 Immunodeficiency 36
Domain Name Domain ID Source
A38748 A38748 PIR
RhoGAP_dom IPR000198 InterPro
SH2 IPR000980 InterPro
SH3_domain IPR001452 InterPro
PI3kinase_P85_p55 IPR001720 InterPro
Rho_GTPase_activation_prot IPR008936 InterPro
PI3K_P85_iSH2 IPR032498 InterPro
PI3kinase_P85_cSH2 IPR035020 InterPro
PI3kinase_P85_nSH2 IPR035022 InterPro
PI3K_p85alpha_SH3 IPR035591 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
RhoGAP PF00620 Pfam
PI3K_P85_iSH2 PF16454 Pfam
SH2DOMAIN PR00401 PRINTS
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
RHOGAP PS50238 PROSITE
PTHR10155 PTHR10155 PANTHER
SH2 SM00252 SMART
RhoGAP SM00324 SMART
SH3 SM00326 SMART
SSF48350 SSF48350 SUPFAM
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_cSH2_p85_like cd09930 CDD
SH2_nSH2_p85_like cd09942 CDD
SH3_PI3K_p85alpha cd11910 CDD