Protein: P27986 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P27986 (Uniprot)	P85A_HUMAN	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	human	No

Protein Function

Uniprot: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an import more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	698	GO:0022610	biological adhesion	869	2.30e-55	4.36e-110
GO:0006928	movement of cell or subcellular component	496	GO:0006139	nucleobase-containing compound metabolic process	698	1.95e-31	6.36e-195
GO:0007165	signal transduction	187, 282, 355, 486	GO:0006139	nucleobase-containing compound metabolic process	698	1.10e-111	5.07e-25
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35, 327	5.53e-55	9.57e-64
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	698	6.88e-41	1.21e-84
GO:0010646	regulation of cell communication	284	GO:0034641	cellular nitrogen compound metabolic process	35, 327	1.59e-39	2.52e-03
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	698	6.71e-28	7.52e-07
GO:0033036	macromolecule localization	517	GO:0006139	nucleobase-containing compound metabolic process	698	4.58e-19	9.70e-72
GO:0034641	cellular nitrogen compound metabolic process	35, 327	GO:0007165	signal transduction	355, 486	4.22e-144	6.90e-18
GO:0034641	cellular nitrogen compound metabolic process	35, 327	GO:0006928	movement of cell or subcellular component	496	7.55e-40	5.63e-168

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
20	GO:0019538	protein metabolic process
20	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
100	GO:0016070	RNA metabolic process
100	GO:0034645	cellular macromolecule biosynthetic process
100	GO:0044271	cellular nitrogen compound biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
20	GO:0005886	plasma membrane
30	GO:0005829	cytosol
30	GO:0043232	intracellular non-membrane-bounded organelle
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
100	GO:0005829	cytosol
100	GO:0005634	nucleus
106	GO:0005829	cytosol
106	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001678	cellular glucose homeostasis	ISS
GO:0001953	negative regulation of cell-matrix adhesion	IEA
GO:0006468	protein phosphorylation	IEA
GO:0006661	phosphatidylinositol biosynthetic process	TAS
GO:0007173	epidermal growth factor receptor signaling pathway	TAS
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0007411	axon guidance	TAS
GO:0008286	insulin receptor signaling pathway	IBA
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IEA

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Cellular Components

Showing 1 to 10 of 11 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	ISS
GO:0005737	cytoplasm	IDA
GO:0005801	cis-Golgi network	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0005911	cell-cell junction	IEA
GO:0005942	phosphatidylinositol 3-kinase complex	IBA
GO:0005943	phosphatidylinositol 3-kinase complex, class IA	ISS
GO:0016020	membrane	IDA
GO:0043234	protein complex	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236

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All Protein Interactions

Showing 1 to 10 of 168 entries

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Interactor	Also a MoonDB EMF protein
ABCG5_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
AIRE_HUMAN	No
AKAP2_HUMAN	No
AKAP6_HUMAN	No
AL2SB_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
APOL5_HUMAN	No
ARAF_HUMAN	No

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Publications Associated

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PMID	Article Title
1849461	Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
7518429	Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
7537849	Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
7541045	Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
7681364	Structure of the PI3K SH3 domain and analysis of the SH3 family.
7692233	Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
8276809	Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
8599763	Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes.
8628286	Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain.
8648629	Crystal structure of P13K SH3 domain at 2.0-A resolution.

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OMIM Diseases Associated

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OMIM ID	Disease Name
269880	SHORT syndrome
615214	Agammaglobulinemia 7, autosomal recessive
616005	Immunodeficiency 36

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Protein Domains Associated

Showing 1 to 10 of 29 entries

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Domain Name	Domain ID	Source
A38748	A38748	PIR
PI3K_P85_iSH2	IPR032498	InterPro
PI3K_P85_iSH2	PF16454	Pfam
PI3K_p85alpha_SH3	IPR035591	InterPro
PI3kinase_P85_cSH2	IPR035020	InterPro
PI3kinase_P85_nSH2	IPR035022	InterPro
PI3kinase_P85_p55	IPR001720	InterPro
PTHR10155	PTHR10155	PANTHER
Rho_GTPase_activation_prot	IPR008936	InterPro
RhoGAP	PF00620	Pfam

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