Protein: Q13480

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13480 (Uniprot) GAB1_HUMAN GAB1 GRB2-associated-binding protein 1 human No
Uniprot: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 35 GO:0007165 signal transduction 355 4.22e-144 6.90e-18
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35 5.53e-55 9.57e-64
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35 1.59e-39 2.52e-03
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
284 GO:0009966 regulation of signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001525 angiogenesis IMP
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007411 axon guidance TAS
GO:0008283 cell proliferation TAS
GO:0008286 insulin receptor signaling pathway TAS
GO:0031532 actin cytoskeleton reorganization IMP
GO:0035728 response to hepatocyte growth factor IEA
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
GO:0038084 vascular endothelial growth factor signaling pathway IMP
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway ISS
GO:0038128 ERBB2 signaling pathway TAS
GO:0045766 positive regulation of angiogenesis IMP
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0090668 endothelial cell chemotaxis to vascular endothelial growth factor IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8596638 A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
12475979 Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
12486104 Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15010462 Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15863030 Cellular signaling by fibroblast growth factor receptors.
16959974 The consensus coding sequences of human breast and colorectal cancers.
18669648 A quantitative atlas of mitotic phosphorylation.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
PH_domain IPR001849 InterPro
PH-like_dom_sf IPR011993 InterPro
PH PF00169 Pfam
PH_DOMAIN PS50003 PROSITE
S68442 S68442 PIR
PH SM00233 SMART
SSF50729 SSF50729 SUPFAM