Protein: P21860

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P21860 (Uniprot) ERBB3_HUMAN ERBB3 Receptor tyrosine-protein kinase erbB-3 human No
Uniprot: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0034641 cellular nitrogen compound metabolic process 35, 327 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327 5.53e-55 9.57e-64
GO:0007165 signal transduction 187, 282, 308 GO:0034641 cellular nitrogen compound metabolic process 35, 327 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
688 GO:0006355 regulation of transcription, DNA-templated
688 GO:0007165 signal transduction
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
162 GO:0005634 nucleus
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
688 GO:0005634 nucleus
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0003197 endocardial cushion development IEA
GO:0007162 negative regulation of cell adhesion IDA
GO:0007165 signal transduction IDA
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS
GO:0007422 peripheral nervous system development ISS
GO:0007507 heart development ISS
GO:0009968 negative regulation of signal transduction IDA
GO:0010628 positive regulation of gene expression IEA
GO:0014037 Schwann cell differentiation ISS
GO:0014065 phosphatidylinositol 3-kinase signaling IDA
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling TAS
GO:0018108 peptidyl-tyrosine phosphorylation IEA
GO:0021545 cranial nerve development ISS
GO:0038128 ERBB2 signaling pathway TAS
GO:0042060 wound healing NAS
GO:0042127 regulation of cell proliferation IDA
GO:0043524 negative regulation of neuron apoptotic process ISS
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0051048 negative regulation of secretion IDA
GO:0051402 neuron apoptotic process IMP
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0055025 positive regulation of cardiac muscle tissue development IEA
GO:0061098 positive regulation of protein tyrosine kinase activity IMP
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade IEA
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IMP
GO:1901185 negative regulation of ERBB signaling pathway TAS
GO:2000145 regulation of cell motility TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005615 extracellular space IDA
GO:0005622 intracellular IEA
GO:0005886 plasma membrane TAS
GO:0005887 integral component of plasma membrane TAS
GO:0016323 basolateral plasma membrane IDA
GO:0016324 apical plasma membrane IEA
GO:0016328 lateral plasma membrane IEA
GO:0043235 receptor complex ISS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0005622 intracellular 1.63e-10 4.39e-07
GO:0005622 intracellular GO:0005886 plasma membrane 0.00e+00 9.14e-55
GO:0005622 intracellular GO:0005887 integral component of plasma membrane 1.86e-124 1.68e-138
GO:0005622 intracellular GO:0043235 receptor complex 7.79e-11 3.44e-05
PMID Article Title
2164210 Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.
2687875 Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
7685162 c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.
9516479 Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.
11325528 Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.
12154198 Structure of the extracellular region of HER3 reveals an interdomain tether.
12939402 Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15358134 Neuroglycan C, a novel member of the neuregulin family.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075 The finished DNA sequence of human chromosome 12.
16832058 Ebp1 isoforms distinctively regulate cell survival and differentiation.
17344846 Patterns of somatic mutation in human cancer genomes.
17701904 Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway.
19369195 Large-scale proteomics analysis of the human kinome.
20007378 Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
20351256 ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation.
20682778 Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.
21575594 Spatial structure and dimer-monomer equilibrium of the ErbB3 transmembrane domain in DPC micelles.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
607598 Lethal congenital contracture syndrome 2
Domain Name Domain ID Source
A36223 A36223 PIR
Rcpt_L-dom IPR000494 InterPro
Prot_kinase_dom IPR000719 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
Furin-like_Cys-rich_dom IPR006211 InterPro
Furin_repeat IPR006212 InterPro
Growth_fac_rcpt_cys_sf IPR009030 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Tyr_kinase_EGF/ERB/XmrK_rcpt IPR016245 InterPro
LRR_dom_sf IPR032675 InterPro
GF_recep_IV IPR032778 InterPro
Rcpt_L-dom_sf IPR036941 InterPro
JH0803 JH0803 PIR
Furin-like PF00757 Pfam
Recep_L_domain PF01030 Pfam
Pkinase_Tyr PF07714 Pfam
GF_recep_IV PF14843 Pfam
TyrPK_EGF-R PIRSF000619 PIRSF
TYRKINASE PR00109 PRINTS
PROTEIN_KINASE_DOM PS50011 PROSITE
FU SM00261 SMART
SSF52058 SSF52058 SUPFAM
SSF56112 SSF56112 SUPFAM
SSF57184 SSF57184 SUPFAM