Protein: P21860 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P21860 (Uniprot)	ERBB3_HUMAN	ERBB3	Receptor tyrosine-protein kinase erbB-3	human	No

Protein Function

Uniprot: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). Ma more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187, 282, 308	GO:0034641	cellular nitrogen compound metabolic process	35, 327	4.22e-144	6.90e-18
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35, 327	5.53e-55	9.57e-64
GO:0034641	cellular nitrogen compound metabolic process	35, 327	GO:0006928	movement of cell or subcellular component	496	7.55e-40	5.63e-168
GO:0034641	cellular nitrogen compound metabolic process	35, 327	GO:0022610	biological adhesion	869	6.87e-63	4.34e-65

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
162	GO:0005634	nucleus
187	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	TAS
GO:0003197	endocardial cushion development	IEA
GO:0007162	negative regulation of cell adhesion	IDA
GO:0007165	signal transduction	IDA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISS
GO:0007422	peripheral nervous system development	ISS
GO:0007507	heart development	ISS
GO:0009968	negative regulation of signal transduction	IDA
GO:0010628	positive regulation of gene expression	IEA
GO:0014037	Schwann cell differentiation	ISS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005615	extracellular space	IDA
GO:0005622	intracellular	IEA
GO:0005886	plasma membrane	TAS
GO:0005887	integral component of plasma membrane	TAS
GO:0016323	basolateral plasma membrane	IDA
GO:0016324	apical plasma membrane	IEA
GO:0016328	lateral plasma membrane	IEA
GO:0043235	receptor complex	ISS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005615	extracellular space	GO:0005622	intracellular	1.63e-10	4.39e-07
GO:0005622	intracellular	GO:0005886	plasma membrane	0.00e+00	9.14e-55
GO:0005622	intracellular	GO:0005887	integral component of plasma membrane	1.86e-124	1.68e-138
GO:0005622	intracellular	GO:0043235	receptor complex	7.79e-11	3.44e-05

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
BCAR3_HUMAN	No
CHIO_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
CRKL_HUMAN	No
DAB1_HUMAN	No
DAPP1_HUMAN	No
EGFR_HUMAN	Yes: P00533 (MoonDB)
EGR1_HUMAN	No

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Publications Associated

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PMID	Article Title
2164210	Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.
2687875	Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.
7685162	c-erbB3 gene encodes secreted as well as transmembrane receptor tyrosine kinase.
9516479	Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3.
11325528	Regulation of the ErbB3 binding protein Ebp1 by protein kinase C.
12154198	Structure of the extracellular region of HER3 reveals an interdomain tether.
12939402	Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15358134	Neuroglycan C, a novel member of the neuregulin family.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

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OMIM ID	Disease Name
607598	Lethal congenital contracture syndrome 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
A36223	A36223	PIR
FU	SM00261	SMART
Furin-like	PF00757	Pfam
Furin-like_Cys-rich_dom	IPR006211	InterPro
Furin_repeat	IPR006212	InterPro
GF_recep_IV	IPR032778	InterPro
GF_recep_IV	PF14843	Pfam
Growth_fac_rcpt_cys_sf	IPR009030	InterPro
JH0803	JH0803	PIR
Kinase-like_dom_sf	IPR011009	InterPro

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