Protein: P19174 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P19174 (Uniprot)	PLCG1_HUMAN	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	human	No

Protein Function

Uniprot: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFR more..

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187	GO:0034641	cellular nitrogen compound metabolic process	35	4.22e-144	6.90e-18
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35	5.53e-55	9.57e-64
GO:0010646	regulation of cell communication	284	GO:0034641	cellular nitrogen compound metabolic process	35	1.59e-39	2.52e-03

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
20	GO:0019538	protein metabolic process
20	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
20	GO:0005886	plasma membrane
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
186	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000186	activation of MAPKK activity	TAS
GO:0001701	in utero embryonic development	IEA
GO:0007165	signal transduction	TAS
GO:0007173	epidermal growth factor receptor signaling pathway	IMP
GO:0007411	axon guidance	TAS
GO:0009395	phospholipid catabolic process	IEA
GO:0010634	positive regulation of epithelial cell migration	IMP
GO:0016032	viral process	IEA
GO:0016477	cell migration	IMP
GO:0019722	calcium-mediated signaling	IMP

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Cellular Components

Showing 1 to 8 of 8 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0001726	ruffle	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0005911	cell-cell junction	IEA
GO:0008180	COP9 signalosome	IDA
GO:0030027	lamellipodium	IDA
GO:0042995	cell projection	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 95 entries

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Interactor	Also a MoonDB EMF protein
3BP2_HUMAN	No
A0A0U1RR93_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
ADNP_HUMAN	No
AFF2_HUMAN	No
AIRE_HUMAN	No
AKAP2_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANT3_HUMAN	No

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Publications Associated

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PMID	Article Title
1370476	Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.
1656221	A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
2167438	Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
7518429	Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
7681365	Solution structure of the SH3 domain of phospholipase C-gamma.
8657103	Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.
9038210	Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
9178760	Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
9489702	LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
10102632	Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A36466	A36466	PIR
C2	PF00168	Pfam
C2	PS50004	PROSITE
C2	SM00239	SMART
C2_dom	IPR000008	InterPro
C2_domain_sf	IPR035892	InterPro
EF-hand-dom_pair	IPR011992	InterPro
EF_HAND_1	PS00018	PROSITE
EF_Hand_1_Ca_BS	IPR018247	InterPro
EF_HAND_2	PS50222	PROSITE

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