Protein: Q8TB24 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8TB24 (Uniprot)	RIN3_HUMAN	RIN3	Ras and Rab interactor 3	human	No

Protein Function

Uniprot: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	462	6.71e-28	7.52e-07

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 5 of 5 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
284	GO:0009966	regulation of signal transduction
451	GO:0007165	signal transduction
451	GO:0016192	vesicle-mediated transport
462	GO:0090304	nucleic acid metabolic process
829	GO:0007165	signal transduction

Previous1Next

Cellular Components

Showing 1 to 10 of 10 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
119	GO:0005829	cytosol
284	GO:0005829	cytosol
284	GO:0005886	plasma membrane
451	GO:0005829	cytosol
451	GO:0012505	endomembrane system
451	GO:0005634	nucleus
462	GO:0005634	nucleus
651	GO:0005829	cytosol
829	GO:0005829	cytosol
829	GO:0031982	vesicle

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 3 of 3 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006897	endocytosis	NAS
GO:0007165	signal transduction	IEA
GO:0043547	positive regulation of GTPase activity	IEA

Previous1Next

Cellular Components

Showing 1 to 3 of 3 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005769	early endosome	IDA
GO:0005829	cytosol	TAS
GO:0031410	cytoplasmic vesicle	IDA

Previous1Next

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 46 entries

Search:

Interactor	Also a MoonDB EMF protein
ABL1_HUMAN	Yes: P00519 (MoonDB)
ASB3_HUMAN	No
ASB8_HUMAN	No
BACD2_HUMAN	No
BIN1_HUMAN	Yes: O00499 (MoonDB)
CP2C8_HUMAN	No
CP46A_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
CRKL_HUMAN	No
CSRP3_HUMAN	No

Previous1 2 3 4 5Next

Publications Associated

Showing 1 to 7 of 7 entries

Search:

PMID	Article Title
11733506	A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.
12508121	The DNA sequence and analysis of human chromosome 14.
12972505	RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18486601	Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.
21586568	Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.

Previous1Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 16 entries

Search:

Domain Name	Domain ID	Source
RA	PS50200	PROSITE
RA_dom	IPR000159	InterPro
RIN3_SH2	IPR035869	InterPro
SH2	IPR000980	InterPro
SH2	PS50001	PROSITE
SH2	SM00252	SMART
SH2_dom_sf	IPR036860	InterPro
SH2_RIN3	cd10395	CDD
SSF109993	SSF109993	SUPFAM
SSF55550	SSF55550	SUPFAM

Previous1 2Next