Protein: Q8TB24

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8TB24 (Uniprot) RIN3_HUMAN RIN3 Ras and Rab interactor 3 human No
Uniprot: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 462 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
284 GO:0009966 regulation of signal transduction
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
462 GO:0090304 nucleic acid metabolic process
829 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
119 GO:0005829 cytosol
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
462 GO:0005634 nucleus
651 GO:0005829 cytosol
829 GO:0005829 cytosol
829 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006897 endocytosis NAS
GO:0007165 signal transduction IEA
GO:0043547 positive regulation of GTPase activity IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005769 early endosome IDA
GO:0005829 cytosol TAS
GO:0031410 cytoplasmic vesicle IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
11733506 A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.
12508121 The DNA sequence and analysis of human chromosome 14.
12972505 RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18486601 Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.
21586568 Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.
No results found.
Domain Name Domain ID Source
RA_dom IPR000159 InterPro
SH2 IPR000980 InterPro
VPS9 IPR003123 InterPro
RIN3_SH2 IPR035869 InterPro
SH2_dom_sf IPR036860 InterPro
VPS9_dom_sf IPR037191 InterPro
VPS9 PF02204 Pfam
SH2 PS50001 PROSITE
RA PS50200 PROSITE
VPS9 PS51205 PROSITE
VPS9 SM00167 SMART
SH2 SM00252 SMART
SSF109993 SSF109993 SUPFAM
SSF55550 SSF55550 SUPFAM
T50623 T50623 PIR
SH2_RIN3 cd10395 CDD