Protein: P16333

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P16333 (Uniprot) NCK1_HUMAN NCK1 Cytoplasmic protein NCK1 human No
Uniprot: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 682 2.49e-18 9.18e-29
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 698 6.88e-41 1.21e-84
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 35, 327 4.22e-144 6.90e-18
GO:0007165 signal transduction 187 GO:0006139 nucleobase-containing compound metabolic process 698 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35, 327 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 698 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
177 GO:0044267 cellular protein metabolic process
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
253 GO:0019538 protein metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
259 GO:0007165 signal transduction
274 GO:0007165 signal transduction
284 GO:0009966 regulation of signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
698 GO:0090304 nucleic acid metabolic process
698 GO:0010646 regulation of cell communication
698 GO:0060255 regulation of macromolecule metabolic process
698 GO:0023051 regulation of signaling
698 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
177 GO:0005634 nucleus
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
254 GO:0005829 cytosol
254 GO:0005634 nucleus
259 GO:0005886 plasma membrane
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
563 GO:0005634 nucleus
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
682 GO:0005634 nucleus
698 GO:0043232 intracellular non-membrane-bounded organelle
698 GO:0031981 nuclear lumen
698 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006469 negative regulation of protein kinase activity IEA
GO:0006930 substrate-dependent cell migration, cell extension IEA
GO:0007015 actin filament organization IEA
GO:0007172 signal complex assembly NAS
GO:0010976 positive regulation of neuron projection development IEA
GO:0030032 lamellipodium assembly IEA
GO:0030334 regulation of cell migration IEA
GO:0030838 positive regulation of actin filament polymerization IMP
GO:0033137 negative regulation of peptidyl-serine phosphorylation IDA
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress IDA
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0042102 positive regulation of T cell proliferation IMP
GO:0042110 T cell activation IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048013 ephrin receptor signaling pathway IEA
GO:0050852 T cell receptor signaling pathway TAS
GO:0051707 response to other organism IEA
GO:0060548 negative regulation of cell death IDA
GO:0070262 peptidyl-serine dephosphorylation IDA
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
GO:1903676 positive regulation of cap-dependent translational initiation IDA
GO:1903679 positive regulation of cap-independent translational initiation IDA
GO:1903898 negative regulation of PERK-mediated unfolded protein response IDA
GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000164 protein phosphatase type 1 complex IDA
GO:0005634 nucleus IEA
GO:0005737 cytoplasm IDA
GO:0005783 endoplasmic reticulum IDA
GO:0005829 cytosol TAS
GO:0005840 ribosome IDA
GO:0005886 plasma membrane TAS
GO:0005911 cell-cell junction IEA
GO:0012506 vesicle membrane IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0012506 vesicle membrane 9.35e-29 3.51e-48
Interactor Also a MoonDB EMF protein
P55G_HUMAN Yes: Q92569 (MoonDB)
ADA15_HUMAN No
FOXH1_HUMAN No
DTBP1_HUMAN No
F110A_HUMAN No
TNFL6_HUMAN No
HXC8_HUMAN No
TRI39_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
SUV92_HUMAN No
ASXL1_HUMAN No
WASL_HUMAN No
PNMA2_HUMAN No
SOCS7_HUMAN No
AIRE_HUMAN No
ACK1_HUMAN No
P2RX7_HUMAN No
CHRD_HUMAN No
DLGP2_HUMAN No
S23A1_HUMAN No
CE170_HUMAN No
TRAIP_HUMAN No
RAG1_HUMAN No
SF3B4_HUMAN No
BRCA1_HUMAN No
NEK8_HUMAN No
MYRIP_HUMAN No
PRIC3_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
SPN90_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
PAR3_HUMAN No
ABCG5_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
ACAP1_HUMAN No
AFF2_HUMAN No
AGRL2_HUMAN No
AKAP2_HUMAN No
AKAP6_HUMAN No
ANK2_HUMAN No
APOL5_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASAP2_HUMAN No
ASB16_HUMAN No
AT2A3_HUMAN No
BAZ2A_HUMAN No
BICRA_HUMAN No
BLNK_HUMAN No
BRD4_HUMAN No
BRPF3_HUMAN No
CAF1A_HUMAN No
CBL_HUMAN No
CCR10_HUMAN No
CD3E_HUMAN No
CDC27_HUMAN No
CELR2_HUMAN No
CELR3_HUMAN No
CHIO_HUMAN No
CKAP5_HUMAN No
CNTFR_HUMAN No
CNTP1_HUMAN No
CO6_HUMAN No
CP4F2_HUMAN No
CSDE1_HUMAN No
CSMD2_HUMAN No
DAB2_HUMAN No
DAG1_HUMAN No
DCE1_HUMAN No
DLGP1_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX4_HUMAN No
DOCK1_HUMAN No
DOCK3_HUMAN No
DUS15_HUMAN No
ECT2_HUMAN No
EFS_HUMAN No
EHMT2_HUMAN No
ELK3_HUMAN No
EPHB1_HUMAN No
EPS15_HUMAN Yes: P42566 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
FANCA_HUMAN Yes: O15360 (MoonDB)
FCG2B_HUMAN No
FCG2C_HUMAN No
FLNB_HUMAN No
FLNC_HUMAN No
FYB1_HUMAN No
GAB1_HUMAN Yes: Q13480 (MoonDB)
GABR1_HUMAN No
GASR_HUMAN No
GHR_HUMAN No
GNS_HUMAN No
GPR45_HUMAN No
H14_HUMAN No
HNRPR_HUMAN No
I20L2_HUMAN No
ICAL_HUMAN No
ID4_HUMAN No
IF2B_HUMAN No
IL3RA_HUMAN No
JAK2_HUMAN No
K1522_HUMAN No
KHDR1_HUMAN No
KI13A_HUMAN No
KIFC2_HUMAN No
KIT_HUMAN No
KMT2B_HUMAN No
LAP2B_HUMAN No
LCP2_HUMAN No
LRRC3_HUMAN No
M4K1_HUMAN No
M4K3_HUMAN No
M4K5_HUMAN No
MAAI_HUMAN No
MAP4_HUMAN No
MED14_HUMAN No
MEPE_HUMAN No
MET_HUMAN No
MINK1_HUMAN No
MINT_HUMAN No
MYLK_HUMAN No
NCKP5_HUMAN No
NCKX1_HUMAN No
NELFB_HUMAN No
NEU1_HUMAN No
NFASC_HUMAN No
NKX21_HUMAN No
NOTC3_HUMAN No
NPA1P_HUMAN No
NPVF_HUMAN No
NXPH3_HUMAN No
OLIG1_HUMAN No
P3C2B_HUMAN No
PAK2_HUMAN No
PAX3_HUMAN No
PAX7_HUMAN No
PDIA2_HUMAN No
PERE_HUMAN No
PHAR2_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PK3CD_HUMAN No
PRAX_HUMAN No
PTN4_HUMAN No
RAGE_HUMAN No
RASA1_HUMAN No
RIMS1_HUMAN No
RIMS2_HUMAN No
RL13_HUMAN No
RL40_HUMAN No
RNC_HUMAN No
RP1L1_HUMAN No
RPA2_HUMAN No
RPGF1_HUMAN No
RPP38_HUMAN No
RRAS_HUMAN No
RYR1_HUMAN No
S22A3_HUMAN No
SASH1_HUMAN No
SELN_HUMAN No
SEM7A_HUMAN No
SH21A_HUMAN No
SHAN2_HUMAN No
SHAN3_HUMAN No
SHRM2_HUMAN No
SNX12_HUMAN No
SNX17_HUMAN No
SNX3_HUMAN No
SNX7_HUMAN No
SNX8_HUMAN No
SOS1_HUMAN No
SOS2_HUMAN No
SP1_HUMAN No
SREC2_HUMAN No
STF1_HUMAN No
SYNJ1_HUMAN No
SYNJ2_HUMAN No
TGDS_HUMAN No
TGON2_HUMAN No
TLR9_HUMAN No
TNIK_HUMAN No
TPX2_HUMAN No
TRYB1_HUMAN No
TRYB2_HUMAN No
TULP1_HUMAN No
VP13A_HUMAN No
WIPF1_HUMAN No
PMID Article Title
1333046 Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.
1448108 The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
2107526 Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.
7692233 Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
9344857 A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.
9430661 Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.
9600074 Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.
9697839 BLNK: a central linker protein in B cell activation.
10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
10747847 Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.
12091389 Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15469942 Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15504032 Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-Cav-2 (pY19 and pY27).
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
16835242 Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
16966330 Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17803907 Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
18088087 Phosphoproteome of resting human platelets.
18269246 Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor.
18296648 Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.
18669648 A quantitative atlas of mitotic phosphorylation.
18835251 Nck-1 interacts with PKR and modulates its activation by dsRNA.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19807924 Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21664272 Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23358419 Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
SH2 IPR000980 InterPro
SH3_domain IPR001452 InterPro
NCK IPR017304 InterPro
Nck1_SH3_1 IPR035562 InterPro
Nck1_SH3_2 IPR035564 InterPro
Nck1_SH3_3 IPR035565 InterPro
Nck1_SH2 IPR035882 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
SH3_9 PF14604 Pfam
Cytoplasmic_NCK PIRSF037874 PIRSF
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
S08636 S08636 PIR
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_Nck1 cd10408 CDD
SH3_Nck1_1 cd11900 CDD
SH3_Nck1_2 cd11901 CDD
SH3_Nck1_3 cd11904 CDD