Protein: P16333 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P16333 (Uniprot)	NCK1_HUMAN	NCK1	Cytoplasmic protein NCK1	human	No

Protein Function

Uniprot: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ more..

MoonDB Dissimilar Functions

Showing 1 to 7 of 7 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187	GO:0034641	cellular nitrogen compound metabolic process	35, 327	4.22e-144	6.90e-18
GO:0007165	signal transduction	187	GO:0006139	nucleobase-containing compound metabolic process	698	1.10e-111	5.07e-25
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35, 327	5.53e-55	9.57e-64
GO:0007166	cell surface receptor signaling pathway	108	GO:0009059	macromolecule biosynthetic process	682	2.49e-18	9.18e-29
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	698	6.88e-41	1.21e-84
GO:0010646	regulation of cell communication	284	GO:0034641	cellular nitrogen compound metabolic process	35, 327	1.59e-39	2.52e-03
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	698	6.71e-28	7.52e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
20	GO:0019538	protein metabolic process
20	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
20	GO:0005886	plasma membrane
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
177	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006469	negative regulation of protein kinase activity	IEA
GO:0006930	substrate-dependent cell migration, cell extension	IEA
GO:0007015	actin filament organization	IEA
GO:0007172	signal complex assembly	NAS
GO:0010976	positive regulation of neuron projection development	IEA
GO:0030032	lamellipodium assembly	IEA
GO:0030334	regulation of cell migration	IEA
GO:0030838	positive regulation of actin filament polymerization	IMP
GO:0033137	negative regulation of peptidyl-serine phosphorylation	IDA
GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000164	protein phosphatase type 1 complex	IDA
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005829	cytosol	TAS
GO:0005840	ribosome	IDA
GO:0005886	plasma membrane	TAS
GO:0005911	cell-cell junction	IEA
GO:0012506	vesicle membrane	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 3 of 3 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0012506	vesicle membrane	9.35e-29	3.51e-48

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All Protein Interactions

Showing 1 to 10 of 188 entries

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Interactor	Also a MoonDB EMF protein
ABCG5_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
ACAP1_HUMAN	No
ACK1_HUMAN	No
ADA15_HUMAN	No
AFF2_HUMAN	No
AGRL2_HUMAN	No
AIRE_HUMAN	No
AKAP2_HUMAN	No

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Publications Associated

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PMID	Article Title
1333046	Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP.
1448108	The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment.
2107526	Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.
7692233	Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
9344857	A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.
9430661	Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase.
9600074	Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.
9697839	BLNK: a central linker protein in B cell activation.
10026169	Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
10747847	Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Cytoplasmic_NCK	PIRSF037874	PIRSF
NCK	IPR017304	InterPro
Nck1_SH2	IPR035882	InterPro
Nck1_SH3_1	IPR035562	InterPro
Nck1_SH3_2	IPR035564	InterPro
Nck1_SH3_3	IPR035565	InterPro
S08636	S08636	PIR
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE

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