Protein: Q92569

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q92569 (Uniprot) P55G_HUMAN PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma human No
Uniprot: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 327 5.53e-55 9.57e-64
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 327 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 327 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
115 GO:0006464 cellular protein modification process
115 GO:0060255 regulation of macromolecule metabolic process
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
244 GO:0006464 cellular protein modification process
244 GO:0060255 regulation of macromolecule metabolic process
244 GO:0007165 signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
387 GO:0019538 protein metabolic process
387 GO:0060255 regulation of macromolecule metabolic process
387 GO:0007165 signal transduction
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
115 GO:0005829 cytosol
115 GO:0005634 nucleus
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
244 GO:0005829 cytosol
244 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0005634 nucleus
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
387 GO:0005829 cytosol
387 GO:0005654 nucleoplasm
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
522 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006661 phosphatidylinositol biosynthetic process TAS
GO:0008286 insulin receptor signaling pathway IBA
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
GO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA
GO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0005942 phosphatidylinositol 3-kinase complex IBA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
ENKD1_HUMAN No
KAP1_HUMAN No
SSBP4_HUMAN No
TRI54_HUMAN No
BLK_HUMAN No
A0A1B0GWI1_HUMAN No
A1AG1_HUMAN No
ABCB6_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
AMBP_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
ANS1A_HUMAN No
AR6P4_HUMAN No
ARI4B_HUMAN No
AUNIP_HUMAN No
BRK1_HUMAN No
BTK_HUMAN No
CBL_HUMAN No
CCD14_HUMAN No
CCD33_HUMAN No
CCD89_HUMAN No
CE126_HUMAN No
CEP19_HUMAN Yes: Q96LK0 (MoonDB)
CLNK_HUMAN No
CQ053_HUMAN No
CRBA2_HUMAN No
CRBN_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
DCAF8_HUMAN No
DISC1_HUMAN Yes: Q9NRI5 (MoonDB)
DSN1_HUMAN No
E2F6_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
ERBB2_HUMAN Yes: P04626 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
EVI1_HUMAN No
F208B_HUMAN No
FAK1_HUMAN No
FBN3_HUMAN No
FER_HUMAN No
FIBB_HUMAN No
FOXO1_HUMAN No
FRS3_HUMAN No
FSD2_HUMAN No
FYN_HUMAN Yes: P06241 (MoonDB)
GAB1_HUMAN Yes: Q13480 (MoonDB)
GO45_HUMAN No
HCK_HUMAN No
HD_HUMAN Yes: P42858 (MoonDB)
HRSL4_HUMAN No
HSH2D_HUMAN No
IGF1R_HUMAN No
IQUB_HUMAN No
IRS1_HUMAN No
KCC1A_HUMAN No
KHDR1_HUMAN No
KIT_HUMAN No
KLC2_HUMAN No
KLF15_HUMAN No
KMT2B_HUMAN No
LC7L2_HUMAN No
LMBL3_HUMAN No
LNX2_HUMAN Yes: Q8N448 (MoonDB)
MBIP1_HUMAN No
MDS1_HUMAN No
MET27_HUMAN No
MET_HUMAN No
MICA1_HUMAN No
MTF2_HUMAN No
MYPT2_HUMAN No
NAB2_HUMAN No
NC2A_HUMAN No
NCK1_HUMAN Yes: P16333 (MoonDB)
NEBL_HUMAN No
OLIG1_HUMAN No
OTU7B_HUMAN No
PACRL_HUMAN No
PAR6A_HUMAN No
PCDB5_HUMAN No
PELI3_HUMAN No
PELO_HUMAN No
PFD3_HUMAN No
PGFRB_HUMAN No
PK3CA_HUMAN No
PK3CB_HUMAN No
PK3CD_HUMAN No
PKHS1_HUMAN No
PLB1_HUMAN No
PPARA_HUMAN No
PSME1_HUMAN No
PWP1_HUMAN No
RB11A_HUMAN No
RET7_HUMAN No
RING1_HUMAN No
RUSC1_HUMAN No
SERF1_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SMRP1_HUMAN No
SOCS4_HUMAN No
SOCS6_HUMAN No
SPSB2_HUMAN No
SPT32_HUMAN No
SRC_HUMAN Yes: P12931 (MoonDB)
SRTD2_HUMAN No
STAT3_HUMAN Yes: P40763 (MoonDB)
SYDC_HUMAN No
SYK_HUMAN No
SYQ_HUMAN No
TERA_HUMAN Yes: P55072 (MoonDB)
TERF2_HUMAN No
TNNC2_HUMAN No
TRM2A_HUMAN No
TSN2_HUMAN No
UBP2_HUMAN Yes: O75604 (MoonDB)
VTDB_HUMAN No
WDFY3_HUMAN No
WRIP1_HUMAN No
ZBT18_HUMAN No
ZMAT1_HUMAN No
ZN281_HUMAN No
ZN451_HUMAN No
PMID Article Title
9524259 Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
12470648 Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
16710414 The DNA sequence and biological annotation of human chromosome 1.
No results found.
Domain Name Domain ID Source
SH2 IPR000980 InterPro
PI3kinase_P85_p55 IPR001720 InterPro
PI3K_P85_iSH2 IPR032498 InterPro
PI3kinase_P85_cSH2 IPR035020 InterPro
PI3kinase_P85_nSH2 IPR035022 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
PI3K_P85_iSH2 PF16454 Pfam
SH2DOMAIN PR00401 PRINTS
SH2 PS50001 PROSITE
PTHR10155 PTHR10155 PANTHER
SH2 SM00252 SMART
SSF55550 SSF55550 SUPFAM
SH2_cSH2_p85_like cd09930 CDD
SH2_nSH2_p85_like cd09942 CDD