Protein: Q92569 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q92569 (Uniprot)	P55G_HUMAN	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma	human	No

Protein Function

Uniprot: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	187	GO:0034641	cellular nitrogen compound metabolic process	327	4.22e-144	6.90e-18
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	327	5.53e-55	9.57e-64
GO:0034641	cellular nitrogen compound metabolic process	327	GO:0006928	movement of cell or subcellular component	496	7.55e-40	5.63e-168

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 77 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction
108	GO:0010604	positive regulation of macromolecule metabolic process
108	GO:0006468	protein phosphorylation
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation

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Cellular Components

Showing 1 to 10 of 30 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
115	GO:0005829	cytosol
115	GO:0005634	nucleus
166	GO:0005829	cytosol
166	GO:0070013	intracellular organelle lumen
166	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

Showing 1 to 5 of 5 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006661	phosphatidylinositol biosynthetic process	TAS
GO:0008286	insulin receptor signaling pathway	IBA
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	IEA
GO:0043551	regulation of phosphatidylinositol 3-kinase activity	IBA
GO:2001275	positive regulation of glucose import in response to insulin stimulus	ISS

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Cellular Components

Showing 1 to 2 of 2 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0005942	phosphatidylinositol 3-kinase complex	IBA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 121 entries

Search:

Interactor	Also a MoonDB EMF protein
A0A1B0GWI1_HUMAN	No
A1AG1_HUMAN	No
ABCB6_HUMAN	No
ABL2_HUMAN	Yes: P42684 (MoonDB)
AMBP_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANS1A_HUMAN	No
AR6P4_HUMAN	No
ARI4B_HUMAN	No
AUNIP_HUMAN	No

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Publications Associated

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PMID	Article Title
9524259	Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
12470648	Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
16710414	The DNA sequence and biological annotation of human chromosome 1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 15 entries

Search:

Domain Name	Domain ID	Source
PI3K_P85_iSH2	IPR032498	InterPro
PI3K_P85_iSH2	PF16454	Pfam
PI3kinase_P85_cSH2	IPR035020	InterPro
PI3kinase_P85_nSH2	IPR035022	InterPro
PI3kinase_P85_p55	IPR001720	InterPro
PTHR10155	PTHR10155	PANTHER
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2	SM00252	SMART

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