Protein: Q9NP31

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NP31 (Uniprot) SH22A_HUMAN SH2D2A SH2 domain-containing protein 2A human No
Uniprot: Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 132 6.88e-41 1.21e-84
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
132 GO:0090304 nucleic acid metabolic process
132 GO:0060255 regulation of macromolecule metabolic process
171 GO:0006464 cellular protein modification process
171 GO:0035556 intracellular signal transduction
171 GO:0009966 regulation of signal transduction
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
132 GO:0005634 nucleus
171 GO:0005829 cytosol
171 GO:0005886 plasma membrane
357 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001525 angiogenesis IEA
GO:0007165 signal transduction TAS
GO:0008283 cell proliferation IEA
GO:0009967 positive regulation of signal transduction IEA
GO:0030154 cell differentiation IEA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm TAS
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9468509 Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites.
10692392 VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor.
10752626 The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15962004 VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.
16710414 The DNA sequence and biological annotation of human chromosome 1.
18669648 A quantitative atlas of mitotic phosphorylation.
No results found.
Domain Name Domain ID Source
SH2 IPR000980 InterPro
SH2D2A_SH2 IPR035884 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH2DOMAIN PR00401 PRINTS
SH2 PS50001 PROSITE
SH2 SM00252 SMART
SSF55550 SSF55550 SUPFAM
SH2_SH2D2A cd10416 CDD