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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q8N448
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q8N448 (Uniprot)
LNX2_HUMAN
LNX2
Ligand of Numb protein X 2
human
No
Protein Function
No associated function.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009059
macromolecule biosynthetic process
401
GO:0006928
movement of cell or subcellular component
496
1.49e-13
8.46e-109
GO:0006928
movement of cell or subcellular component
496
GO:0006139
nucleobase-containing compound metabolic process
527
1.95e-31
6.36e-195
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
54
GO:0010467
gene expression
54
GO:0006139
nucleobase-containing compound metabolic process
54
GO:0060255
regulation of macromolecule metabolic process
244
GO:0006464
cellular protein modification process
244
GO:0060255
regulation of macromolecule metabolic process
244
GO:0007165
signal transduction
401
GO:0034645
cellular macromolecule biosynthetic process
401
GO:0060255
regulation of macromolecule metabolic process
476
GO:0010467
gene expression
476
GO:0060255
regulation of macromolecule metabolic process
496
GO:0048870
cell motility
496
GO:0071310
cellular response to organic substance
496
GO:0090304
nucleic acid metabolic process
496
GO:0034654
nucleobase-containing compound biosynthetic process
496
GO:0043085
positive regulation of catalytic activity
496
GO:0031325
positive regulation of cellular metabolic process
496
GO:1902533
positive regulation of intracellular signal transduction
496
GO:0010604
positive regulation of macromolecule metabolic process
496
GO:0051173
positive regulation of nitrogen compound metabolic process
496
GO:0051128
regulation of cellular component organization
496
GO:2000112
regulation of cellular macromolecule biosynthetic process
496
GO:0010468
regulation of gene expression
496
GO:0043549
regulation of kinase activity
496
GO:0019219
regulation of nucleobase-containing compound metabolic process
496
GO:0001932
regulation of protein phosphorylation
496
GO:0009719
response to endogenous stimulus
496
GO:1901700
response to oxygen-containing compound
496
GO:0007169
transmembrane receptor protein tyrosine kinase signaling pathway
527
GO:0090304
nucleic acid metabolic process
527
GO:0060255
regulation of macromolecule metabolic process
589
GO:0016070
RNA metabolic process
589
GO:0010467
gene expression
589
GO:0031325
positive regulation of cellular metabolic process
589
GO:2000112
regulation of cellular macromolecule biosynthetic process
589
GO:0019219
regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
54
GO:0070013
intracellular organelle lumen
54
GO:0005634
nucleus
208
GO:0005634
nucleus
231
GO:0005634
nucleus
244
GO:0005829
cytosol
244
GO:0043232
intracellular non-membrane-bounded organelle
352
GO:0005634
nucleus
401
GO:0005634
nucleus
476
GO:0005634
nucleus
496
GO:0005829
cytosol
496
GO:0005634
nucleus
496
GO:0005886
plasma membrane
527
GO:0005634
nucleus
589
GO:0005829
cytosol
589
GO:0005634
nucleus
642
GO:0005634
nucleus
805
GO:0005634
nucleus
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0051260
protein homooligomerization
IEA
Cellular Components
No results found.
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
TRAF1_HUMAN
No
TRAF2_HUMAN
No
GLRX3_HUMAN
No
NTAQ1_HUMAN
Yes:
Q96HA8 (MoonDB)
ZN581_HUMAN
No
FHL3_HUMAN
No
RPAC1_HUMAN
No
PPL13_HUMAN
No
MSRB3_HUMAN
No
MLX_HUMAN
No
P55G_HUMAN
Yes:
Q92569 (MoonDB)
OPTN_HUMAN
No
LMBL2_HUMAN
No
ZN410_HUMAN
No
LNX1_HUMAN
Yes:
Q8TBB1 (MoonDB)
SCNM1_HUMAN
No
UBP2_HUMAN
Yes:
O75604 (MoonDB)
TCL1A_HUMAN
No
MK09_HUMAN
No
GRB2_HUMAN
Yes:
P62993 (MoonDB)
UBE2H_HUMAN
Yes:
P62256 (MoonDB)
IL16_HUMAN
No
CBX4_HUMAN
No
PPIL1_HUMAN
No
PEG10_HUMAN
No
SRS11_HUMAN
No
MCM7_HUMAN
No
NAGK_HUMAN
No
UBC9_HUMAN
Yes:
P63279 (MoonDB)
MYLIP_HUMAN
No
RN138_HUMAN
No
GRAP2_HUMAN
No
ROP1A_HUMAN
No
LRC8E_HUMAN
No
ZN148_HUMAN
No
CDN2C_HUMAN
No
UBE2Z_HUMAN
No
CRK_HUMAN
Yes:
P46108 (MoonDB)
RFA2_HUMAN
No
PSMF1_HUMAN
No
CDK4_HUMAN
No
P85A_HUMAN
Yes:
P27986 (MoonDB)
1433S_HUMAN
No
MR1L1_HUMAN
No
NC2A_HUMAN
No
TIFA_HUMAN
No
TAB1_HUMAN
Yes:
Q15750 (MoonDB)
SPF45_HUMAN
No
TCPG_HUMAN
No
AT2L2_HUMAN
No
ATPB_HUMAN
No
CABP4_HUMAN
No
CCD94_HUMAN
No
CD8A_HUMAN
No
CDK2_HUMAN
No
CJ088_HUMAN
No
CXAR_HUMAN
No
DDA1_HUMAN
No
EAF2_HUMAN
No
FANCG_HUMAN
Yes:
O15287 (MoonDB)
GA45A_HUMAN
No
IGSF5_HUMAN
No
INMT_HUMAN
No
IP6K2_HUMAN
No
MDGA1_HUMAN
No
MP2K5_HUMAN
No
NMD3_HUMAN
No
NUD14_HUMAN
No
NUMB_HUMAN
No
PARVG_HUMAN
No
PKDRE_HUMAN
No
PPIH_HUMAN
No
PSMD5_HUMAN
No
PTCD3_HUMAN
No
PZRN3_HUMAN
No
PZRN4_HUMAN
No
RAB6B_HUMAN
No
RNF12_HUMAN
No
SCLY_HUMAN
No
SHLB2_HUMAN
No
SHSA2_HUMAN
No
TBB5_HUMAN
No
TBCD7_HUMAN
No
UBE2T_HUMAN
No
VTNC_HUMAN
No
Publications Associated
PMID
Article Title
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057823
The DNA sequence and analysis of human chromosome 13.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648
A quantitative atlas of mitotic phosphorylation.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
PDZ
IPR001478
InterPro
Znf_RING
IPR001841
InterPro
Znf_RING/FYVE/PHD
IPR013083
InterPro
Znf_RING_CS
IPR017907
InterPro
PDZ_sf
IPR036034
InterPro
PDZ
PF00595
Pfam
ZF_RING_1
PS00518
PROSITE
ZF_RING_2
PS50089
PROSITE
PDZ
PS50106
PROSITE
RING
SM00184
SMART
PDZ
SM00228
SMART
SSF50156
SSF50156
SUPFAM