Protein: P62256 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P62256 (Uniprot)	UBE2H_HUMAN	UBE2H	Ubiquitin-conjugating enzyme E2 H	human	No

Protein Function

Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	384	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 14 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
155	GO:0006464	cellular protein modification process
155	GO:0060255	regulation of macromolecule metabolic process
384	GO:0034645	cellular macromolecule biosynthetic process
384	GO:0006464	cellular protein modification process
384	GO:0090304	nucleic acid metabolic process
384	GO:0031326	regulation of cellular biosynthetic process
384	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
155	GO:0005634	nucleus
231	GO:0005634	nucleus
384	GO:0005829	cytosol
384	GO:0031981	nuclear lumen
841	GO:0005829	cytosol
841	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006511	ubiquitin-dependent protein catabolic process	TAS
GO:0016567	protein ubiquitination	TAS
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0070936	protein K48-linked ubiquitination	IDA
GO:0070979	protein K11-linked ubiquitination	IDA

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IBA
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 47 entries

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Interactor	Also a MoonDB EMF protein
AES_HUMAN	Yes: Q08117 (MoonDB)
BRAP_HUMAN	No
BYST_HUMAN	No
CBLC_HUMAN	No
CD99_HUMAN	No
CSN5_HUMAN	No
DHYS_HUMAN	No
DNM1L_HUMAN	No
DTX3_HUMAN	No
DTX3L_HUMAN	No

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Publications Associated

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PMID	Article Title
8132613	A human ubiquitin-conjugating enzyme homologous to yeast UBC8.
12690205	Human chromosome 7: DNA sequence and biology.
12853948	The DNA sequence of human chromosome 7.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17588522	E3-independent monoubiquitination of ubiquitin-binding proteins.
20061386	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460	Initial characterization of the human central proteome.
22496338	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
A53516	A53516	PIR
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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