Protein: P62256

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P62256 (Uniprot) UBE2H_HUMAN UBE2H Ubiquitin-conjugating enzyme E2 H human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 384 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
841 GO:0044267 cellular protein metabolic process
841 GO:0009059 macromolecule biosynthetic process
841 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
125 GO:0005829 cytosol
125 GO:0005634 nucleus
155 GO:0005634 nucleus
231 GO:0005634 nucleus
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
841 GO:0005829 cytosol
841 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006511 ubiquitin-dependent protein catabolic process TAS
GO:0016567 protein ubiquitination TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
GO:0070936 protein K48-linked ubiquitination IDA
GO:0070979 protein K11-linked ubiquitination IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IBA
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8132613 A human ubiquitin-conjugating enzyme homologous to yeast UBC8.
12690205 Human chromosome 7: DNA sequence and biology.
12853948 The DNA sequence of human chromosome 7.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17588522 E3-independent monoubiquitination of ubiquitin-binding proteins.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21269460 Initial characterization of the human central proteome.
22496338 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
No results found.
Domain Name Domain ID Source
A53516 A53516 PIR
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD