Protein: Q9C035

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9C035 (Uniprot) TRIM5_HUMAN TRIM5 Tripartite motif-containing protein 5 human No
Uniprot: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 5, 384 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
5 GO:0034645 cellular macromolecule biosynthetic process
5 GO:0006464 cellular protein modification process
5 GO:0090304 nucleic acid metabolic process
5 GO:0034654 nucleobase-containing compound biosynthetic process
5 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
444 GO:0090304 nucleic acid metabolic process
444 GO:0060255 regulation of macromolecule metabolic process
444 GO:0019219 regulation of nucleobase-containing compound metabolic process
444 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
5 GO:0005829 cytosol
5 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
444 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002218 activation of innate immune response IDA
GO:0002221 pattern recognition receptor signaling pathway IEA
GO:0006914 autophagy IDA
GO:0016032 viral process IEA
GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway IMP
GO:0032880 regulation of protein localization IMP
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
GO:0043410 positive regulation of MAPK cascade IMP
GO:0045087 innate immune response IDA
GO:0046597 negative regulation of viral entry into host cell IDA
GO:0051091 positive regulation of DNA binding transcription factor activity IMP
GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
GO:0051607 defense response to virus TAS
GO:0060333 interferon-gamma-mediated signaling pathway TAS
GO:0070534 protein K63-linked ubiquitination IDA
GO:1902187 negative regulation of viral release from host cell IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000932 P-body IDA
GO:0005634 nucleus IEA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:1990462 omegasome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
11331580 The tripartite motif family identifies cell compartments.
12878161 BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15249690 Trim5alpha protein restricts both HIV-1 and murine leukemia virus.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16401428 High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.
16474118 Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16643975 Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1.
16809279 Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection.
16956947 Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection.
17156811 Unique features of TRIM5alpha among closely related human TRIM family members.
18312418 Ubiquitination of E3 ubiquitin ligase TRIM5 alpha and its potential role.
20053985 Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha.
20357094 p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.
21035162 Human Trim5alpha has additional activities that are uncoupled from retroviral capsid recognition.
21247355 Recent insights into the mechanism and consequences of TRIM5alpha retroviral restriction.
21512569 Immunology: TRIM5 does double duty.
21512573 TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
21572451 Antiviral immunity: TRIM5 moonlights as a pattern recognition receptor.
21575904 Trim5 TAKes on pattern recognition.
21632761 Modulation of TRIM5alpha activity in human cells by alternatively spliced TRIM5 isoforms.
21680743 Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.
21734049 Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.
21866272 TRIM5 acts as more than a retroviral restriction factor.
22078707 TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22291694 TRIM5alpha and species tropism of HIV/SIV.
22482711 TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25127057 TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
No results found.
Domain Name Domain ID Source
Znf_B-box IPR000315 InterPro
Znf_RING IPR001841 InterPro
B30.2/SPRY IPR001870 InterPro
SPRY_dom IPR003877 InterPro
Butyrophylin_SPRY IPR003879 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
ConA-like_dom_sf IPR013320 InterPro
Znf_RING_CS IPR017907 InterPro
Znf-RING_LisH IPR027370 InterPro
TRIM5 IPR032917 InterPro
SPRY PF00622 Pfam
zf-B_box PF00643 Pfam
zf-RING_UBOX PF13445 Pfam
BUTYPHLNCDUF PR01407 PRINTS
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
ZF_BBOX PS50119 PROSITE
B302_SPRY PS50188 PROSITE
PTHR24103:SF426 PTHR24103:SF426 PANTHER
RING SM00184 SMART
BBOX SM00336 SMART
SPRY SM00449 SMART
SSF49899 SSF49899 SUPFAM
BBOX cd00021 CDD