Protein: P62837 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P62837 (Uniprot)	UB2D2_HUMAN	UBE2D2	Ubiquitin-conjugating enzyme E2 D2	human	No

Protein Function

Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PE more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
270	GO:0034645	cellular macromolecule biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
125	GO:0005829	cytosol
125	GO:0005634	nucleus
134	GO:0005829	cytosol
134	GO:0005634	nucleus
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus
359	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000209	protein polyubiquitination	IDA
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS
GO:0006464	cellular protein modification process	TAS
GO:0006511	ubiquitin-dependent protein catabolic process	TAS
GO:0016567	protein ubiquitination	TAS
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS
GO:0038095	Fc-epsilon receptor signaling pathway	TAS
GO:0050852	T cell receptor signaling pathway	TAS
GO:0051865	protein autoubiquitination	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000151	ubiquitin ligase complex	IDA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS
GO:0043234	protein complex	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AMFR_HUMAN	No
ARI2_HUMAN	No
ARRD3_HUMAN	No
BFAR_HUMAN	No
BIRC2_HUMAN	No
BIRC3_HUMAN	No
BIRC7_HUMAN	No
BIRC8_HUMAN	No
BRCA1_HUMAN	No
CAPS2_HUMAN	No

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Publications Associated

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PMID	Article Title
7724550	Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).
8530467	Identification of a family of closely related human ubiquitin conjugating enzymes.
10329681	Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.
10918611	SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4.
12036302	PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15001359	An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.
15280377	Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.
15372022	The DNA sequence and comparative analysis of human chromosome 5.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
I59365	I59365	PIR
SSF54495	SSF54495	SUPFAM
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UQ_con	PF00179	Pfam

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