Protein: P51668

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P51668 (Uniprot) UB2D1_HUMAN UBE2D1 Ubiquitin-conjugating enzyme E2 D1 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0000209 protein polyubiquitination IDA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0006511 ubiquitin-dependent protein catabolic process IDA
GO:0016567 protein ubiquitination TAS
GO:0016579 protein deubiquitination TAS
GO:0030509 BMP signaling pathway TAS
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS
GO:0031398 positive regulation of protein ubiquitination IDA
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0070936 protein K48-linked ubiquitination IDA
GO:1902916 positive regulation of protein polyubiquitination IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0043234 protein complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
MEOX2_HUMAN Yes: P50222 (MoonDB)
TRI27_HUMAN Yes: P14373 (MoonDB)
TRI54_HUMAN No
DTX2_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
BIRC2_HUMAN No
BIRC7_HUMAN No
IKBA_HUMAN No
RNF5_HUMAN No
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
TRI39_HUMAN No
ARI2_HUMAN No
TRI50_HUMAN No
DZIP3_HUMAN No
SIR6_HUMAN No
TRI37_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
RNF38_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
CG025_HUMAN No
MYLIP_HUMAN No
TRI18_HUMAN No
RNF37_HUMAN No
RNF4_HUMAN No
RING1_HUMAN No
TRAF7_HUMAN No
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
DTX3_HUMAN No
DTX3L_HUMAN No
TRI43_HUMAN No
RN125_HUMAN No
RN185_HUMAN No
BIRC8_HUMAN No
RING2_HUMAN No
TRI31_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM2_HUMAN No
MKRN2_HUMAN No
RN167_HUMAN Yes: Q9H6Y7 (MoonDB)
MARH7_HUMAN No
BFAR_HUMAN No
TRI35_HUMAN No
RN114_HUMAN No
TRI17_HUMAN No
TRI38_HUMAN No
BRCA1_HUMAN No
ANXA1_HUMAN No
RN103_HUMAN No
AMFR_HUMAN No
ANXA7_HUMAN No
ARRD3_HUMAN No
BIRC3_HUMAN No
BRX1_HUMAN No
CAPS2_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CHFR_HUMAN No
DTX1_HUMAN No
EI24_HUMAN No
ELF3_HUMAN No
GA45A_HUMAN No
GOLI_HUMAN No
GSK3B_HUMAN No
HCD2_HUMAN No
M3K1_HUMAN No
MDM2_HUMAN Yes: Q00987 (MoonDB)
MGRN1_HUMAN No
MIB1_HUMAN No
MKNK1_HUMAN No
MKRN1_HUMAN No
MUL1_HUMAN No
NR1H2_HUMAN Yes: P55055 (MoonDB)
OTUB1_HUMAN No
PJA2_HUMAN No
Q8NEX1_HUMAN No
RBX2_HUMAN No
RFWD3_HUMAN No
RL28_HUMAN No
RN115_HUMAN Yes: Q9Y4L5 (MoonDB)
RN126_HUMAN No
RN146_HUMAN No
RN150_HUMAN No
RN165_HUMAN No
RN166_HUMAN No
RN181_HUMAN No
RNF10_HUMAN No
RNF11_HUMAN No
RNF12_HUMAN No
RNF13_HUMAN No
RNF14_HUMAN No
RNF25_HUMAN No
RNF26_HUMAN No
RNF43_HUMAN No
RS17_HUMAN No
RS7_HUMAN No
SNURF_HUMAN No
T22D1_HUMAN No
TAF1D_HUMAN No
TNNT1_HUMAN No
TOPRS_HUMAN No
TRAF6_HUMAN Yes: Q9Y4K3 (MoonDB)
TRI10_HUMAN No
TRI11_HUMAN No
TRI25_HUMAN No
TRI26_HUMAN No
TRI45_HUMAN No
TRI55_HUMAN No
TRI62_HUMAN No
TRIM3_HUMAN No
TRIM7_HUMAN No
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
UBC_HUMAN Yes: P0CG48 (MoonDB)
UBE4A_HUMAN No
UBTD1_HUMAN No
UFL1_HUMAN No
UFM1_HUMAN No
ZNFX1_HUMAN No
ZNRF1_HUMAN No
ZNRF2_HUMAN No
ZNRF4_HUMAN No
PMID Article Title
8090726 Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.
9362508 Functional expression cloning and characterization of SFT, a stimulator of Fe transport.
11389839 Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
12480712 UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up-regulated in hereditary hemochromatosis.
14562029 The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164054 The DNA sequence and comparative analysis of human chromosome 10.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17588522 E3-independent monoubiquitination of ubiquitin-binding proteins.
18042044 Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.
18359941 Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.
18845142 The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.
19103148 CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.
19854139 Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
21685362 The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
22496338 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
No results found.
Domain Name Domain ID Source
I39202 I39202 PIR
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD