Protein: Q9Y4L5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9Y4L5 (Uniprot)	RN115_HUMAN	RNF115	E3 ubiquitin-protein ligase RNF115	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, more..

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	192, 270	6.37e-04	1.88e-40

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 22 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
175	GO:0044267	cellular protein metabolic process
175	GO:0006139	nucleobase-containing compound metabolic process
175	GO:0010468	regulation of gene expression
192	GO:0034645	cellular macromolecule biosynthetic process

Previous1 2 3Next

Cellular Components

Showing 1 to 10 of 11 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
125	GO:0005829	cytosol
125	GO:0005634	nucleus
175	GO:0005829	cytosol
175	GO:0005634	nucleus
192	GO:0005829	cytosol
192	GO:0005654	nucleoplasm
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen

Previous1 2Next

Protein GO Annotations

Biological Processes

Showing 1 to 8 of 8 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000209	protein polyubiquitination	TAS
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	IMP
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IBA
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP
GO:0051865	protein autoubiquitination	IDA
GO:0070534	protein K63-linked ubiquitination	ISS
GO:0070936	protein K48-linked ubiquitination	ISS

Previous1Next

Cellular Components

Showing 1 to 1 of 1 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS

Previous1Next

Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 22 entries

Search:

Interactor	Also a MoonDB EMF protein
1433S_HUMAN	No
ATN1_HUMAN	No
CDK10_HUMAN	No
CYTC_HUMAN	No
DAZP2_HUMAN	Yes: Q15038 (MoonDB)
DOCK4_HUMAN	No
FOLR3_HUMAN	No
MDM4_HUMAN	Yes: O15151 (MoonDB)
MFAP4_HUMAN	No
RASH_HUMAN	No

Previous1 2 3Next

Publications Associated

Showing 1 to 8 of 8 entries

Search:

PMID	Article Title
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16288031	A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer.
16710414	The DNA sequence and biological annotation of human chromosome 1.
16925951	Novel RING E3 ubiquitin ligases in breast cancer.
18819927	Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
23418353	The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.

Previous1Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 5 of 5 entries

Search:

Domain Name	Domain ID	Source
RING	SM00184	SMART
zf-RING_2	PF13639	Pfam
ZF_RING_2	PS50089	PROSITE
Znf_RING	IPR001841	InterPro
Znf_RING/FYVE/PHD	IPR013083	InterPro

Previous1Next