Protein: O15151 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O15151 (Uniprot)	MDM4_HUMAN	MDM4	Protein Mdm4	human	No

Protein Function

Uniprot: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	391	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
159	GO:0006464	cellular protein modification process
159	GO:0006355	regulation of transcription, DNA-templated
159	GO:0007165	signal transduction
391	GO:0034645	cellular macromolecule biosynthetic process
391	GO:0090304	nucleic acid metabolic process
391	GO:0034654	nucleobase-containing compound biosynthetic process
391	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

Showing 1 to 6 of 6 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
159	GO:0005829	cytosol
159	GO:0005654	nucleoplasm
391	GO:0070013	intracellular organelle lumen
391	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0006461	protein complex assembly	IDA
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS
GO:0008283	cell proliferation	IEP
GO:0008285	negative regulation of cell proliferation	TAS
GO:0016567	protein ubiquitination	IEA
GO:0016579	protein deubiquitination	TAS
GO:0030330	DNA damage response, signal transduction by p53 class mediator	IEP
GO:0042177	negative regulation of protein catabolic process	IMP
GO:0043066	negative regulation of apoptotic process	IEA

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	NAS
GO:0005654	nucleoplasm	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BY55_HUMAN	No
CA109_HUMAN	No
CAN7_HUMAN	No
CHK1_HUMAN	No
DSCR3_HUMAN	No
E2F1_HUMAN	No
HS90B_HUMAN	Yes: P08238 (MoonDB)
LRSM1_HUMAN	Yes: Q6UWE0 (MoonDB)
MAGA1_HUMAN	No
MAT1_HUMAN	Yes: P51948 (MoonDB)

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Publications Associated

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PMID	Article Title
9226370	Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.
10608892	Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
11840567	Cluster analysis of an extensive human breast cancer cell line protein expression map database.
12761890	Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16163388	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
16266988	Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.
16511572	14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
16710414	The DNA sequence and biological annotation of human chromosome 1.
19838211	MdmX is a substrate for the deubiquitinating enzyme USP2a.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 18 entries

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Domain Name	Domain ID	Source
MDM4	IPR015458	InterPro
MDM4	PIRSF500699	PIRSF
p53_MDM_2/4	PIRSF006748	PIRSF
p53_neg-reg_MDM_2/4	IPR016495	InterPro
PTHR13844:SF20	PTHR13844:SF20	PANTHER
SSF47592	SSF47592	SUPFAM
SSF90209	SSF90209	SUPFAM
SWIB	PF02201	Pfam
SWIB_MDM2_dom_sf	IPR036885	InterPro
SWIB_MDM2_domain	IPR003121	InterPro

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