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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: O15151
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
O15151 (Uniprot)
MDM4_HUMAN
MDM4
Protein Mdm4
human
No
Protein Function
Uniprot:
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009056
catabolic process
125
GO:0009059
macromolecule biosynthetic process
391
6.37e-04
1.88e-40
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 11 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
125
GO:0044248
cellular catabolic process
125
GO:0016567
protein ubiquitination
125
GO:0060255
regulation of macromolecule metabolic process
159
GO:0006464
cellular protein modification process
159
GO:0006355
regulation of transcription, DNA-templated
159
GO:0007165
signal transduction
391
GO:0034645
cellular macromolecule biosynthetic process
391
GO:0090304
nucleic acid metabolic process
391
GO:0034654
nucleobase-containing compound biosynthetic process
391
GO:0060255
regulation of macromolecule metabolic process
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Cellular Components
Showing 1 to 6 of 6 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
125
GO:0005829
cytosol
125
GO:0005634
nucleus
159
GO:0005829
cytosol
159
GO:0005654
nucleoplasm
391
GO:0070013
intracellular organelle lumen
391
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 15 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IDA
GO:0006461
protein complex assembly
IDA
GO:0006977
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
TAS
GO:0008283
cell proliferation
IEP
GO:0008285
negative regulation of cell proliferation
TAS
GO:0016567
protein ubiquitination
IEA
GO:0016579
protein deubiquitination
TAS
GO:0030330
DNA damage response, signal transduction by p53 class mediator
IEP
GO:0042177
negative regulation of protein catabolic process
IMP
GO:0043066
negative regulation of apoptotic process
IEA
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
NAS
GO:0005654
nucleoplasm
TAS
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 22 entries
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Interactor
Also a MoonDB EMF protein
BY55_HUMAN
No
CA109_HUMAN
No
CAN7_HUMAN
No
CHK1_HUMAN
No
DSCR3_HUMAN
No
E2F1_HUMAN
No
HS90B_HUMAN
Yes:
P08238 (MoonDB)
LRSM1_HUMAN
Yes:
Q6UWE0 (MoonDB)
MAGA1_HUMAN
No
MAT1_HUMAN
Yes:
P51948 (MoonDB)
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Publications Associated
Showing 1 to 10 of 11 entries
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PMID
Article Title
9226370
Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.
10608892
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
11840567
Cluster analysis of an extensive human breast cancer cell line protein expression map database.
12761890
Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16163388
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
16266988
Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.
16511572
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
16710414
The DNA sequence and biological annotation of human chromosome 1.
19838211
MdmX is a substrate for the deubiquitinating enzyme USP2a.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 18 entries
Search:
Domain Name
Domain ID
Source
MDM4
IPR015458
InterPro
MDM4
PIRSF500699
PIRSF
p53_MDM_2/4
PIRSF006748
PIRSF
p53_neg-reg_MDM_2/4
IPR016495
InterPro
PTHR13844:SF20
PTHR13844:SF20
PANTHER
SSF47592
SSF47592
SUPFAM
SSF90209
SSF90209
SUPFAM
SWIB
PF02201
Pfam
SWIB_MDM2_dom_sf
IPR036885
InterPro
SWIB_MDM2_domain
IPR003121
InterPro
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