Protein: P51948

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P51948 (Uniprot) MAT1_HUMAN MNAT1 CDK-activating kinase assembly factor MAT1 human No
Uniprot: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 5, 384 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
5 GO:0034645 cellular macromolecule biosynthetic process
5 GO:0006464 cellular protein modification process
5 GO:0090304 nucleic acid metabolic process
5 GO:0034654 nucleobase-containing compound biosynthetic process
5 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
198 GO:0060255 regulation of macromolecule metabolic process
198 GO:0007165 signal transduction
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
5 GO:0005829 cytosol
5 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
198 GO:0005829 cytosol
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
GO:0000082 G1/S transition of mitotic cell cycle TAS
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0006281 DNA repair TAS
GO:0006283 transcription-coupled nucleotide-excision repair TAS
GO:0006294 nucleotide-excision repair, preincision complex assembly TAS
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA
GO:0006361 transcription initiation from RNA polymerase I promoter TAS
GO:0006362 transcription elongation from RNA polymerase I promoter TAS
GO:0006363 termination of RNA polymerase I transcription TAS
GO:0006366 transcription from RNA polymerase II promoter TAS
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0006368 transcription elongation from RNA polymerase II promoter TAS
GO:0006370 7-methylguanosine mRNA capping TAS
GO:0006461 protein complex assembly TAS
GO:0006468 protein phosphorylation IEA
GO:0007512 adult heart development IEA
GO:0008283 cell proliferation TAS
GO:0021591 ventricular system development IEA
GO:0043066 negative regulation of apoptotic process IEA
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0048661 positive regulation of smooth muscle cell proliferation IEA
GO:0051592 response to calcium ion IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0005675 holo TFIIH complex IDA
GO:0005829 cytosol IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8521393 Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.
8521818 In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.
9852112 Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
10024882 Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
11056162 Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family.
12508121 The DNA sequence and analysis of human chromosome 14.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19369195 Large-scale proteomics analysis of the human kinome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
G02764 G02764 PIR
Znf_RING IPR001841 InterPro
UIM_dom IPR003903 InterPro
MAT1/Tfb3 IPR004575 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Cdk-activating_kinase_MAT1_cen IPR015877 InterPro
Znf_RING_CS IPR017907 InterPro
MAT1 PF06391 Pfam
zf-C3HC4_5 PF17121 Pfam
MAT1_metazoa PIRSF003338 PIRSF
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
UIM PS50330 PROSITE
PTHR12683:SF13 PTHR12683:SF13 PANTHER
S60157 S60157 PIR
RING SM00184 SMART
cdk7 TIGR00570 TIGRFAMs