Protein: Q9Y2X8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y2X8 (Uniprot) UB2D4_HUMAN UBE2D4 Ubiquitin-conjugating enzyme E2 D4 human No
Uniprot: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
575 GO:0016567 protein ubiquitination
575 GO:0060255 regulation of macromolecule metabolic process
696 GO:0022607 cellular component assembly
696 GO:0006464 cellular protein modification process
696 GO:0060255 regulation of macromolecule metabolic process
696 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
359 GO:0005634 nucleus
375 GO:0005829 cytosol
375 GO:0005634 nucleus
575 GO:0005654 nucleoplasm
696 GO:0005829 cytosol
696 GO:0043232 intracellular non-membrane-bounded organelle
696 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0016567 protein ubiquitination IDA
GO:0035519 protein K29-linked ubiquitination IDA
GO:0044314 protein K27-linked ubiquitination IDA
GO:0070534 protein K63-linked ubiquitination IDA
GO:0070936 protein K48-linked ubiquitination IDA
GO:0070979 protein K11-linked ubiquitination IDA
GO:0085020 protein K6-linked ubiquitination IDA
No results found.
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
DAZP2_HUMAN Yes: Q15038 (MoonDB)
PROP1_HUMAN No
TRI27_HUMAN Yes: P14373 (MoonDB)
REL_HUMAN No
TRI54_HUMAN No
DTX2_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
NEMO_HUMAN Yes: Q9Y6K9 (MoonDB)
RNF5_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
TRIM1_HUMAN Yes: Q9UJV3 (MoonDB)
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
TRI39_HUMAN No
ARI2_HUMAN No
TRI50_HUMAN No
MAGAB_HUMAN Yes: P43364 (MoonDB)
DZIP3_HUMAN No
INCA1_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
RNF38_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
TRI18_HUMAN No
RNF37_HUMAN No
RNF4_HUMAN No
RING1_HUMAN No
TRAF7_HUMAN No
LRSM1_HUMAN Yes: Q6UWE0 (MoonDB)
MARH3_HUMAN No
DTX3_HUMAN No
DTX3L_HUMAN No
RN138_HUMAN No
TRI43_HUMAN No
RN125_HUMAN No
RN185_HUMAN No
BIRC8_HUMAN No
UHRF2_HUMAN No
RING2_HUMAN No
HOIL1_HUMAN No
TRI31_HUMAN No
TRIM5_HUMAN Yes: Q9C035 (MoonDB)
TRIM2_HUMAN No
MKRN2_HUMAN No
RN167_HUMAN Yes: Q9H6Y7 (MoonDB)
BFAR_HUMAN No
TRI35_HUMAN No
RN114_HUMAN No
TRI17_HUMAN No
TRI38_HUMAN No
RN103_HUMAN No
AL1A2_HUMAN No
AMFR_HUMAN No
CAPS2_HUMAN No
CARM1_HUMAN No
CHFR_HUMAN No
CNOT4_HUMAN No
DTX1_HUMAN No
GOLI_HUMAN No
M3K1_HUMAN No
MGRN1_HUMAN No
MIB1_HUMAN No
MKRN1_HUMAN No
MUL1_HUMAN No
MYBB_HUMAN No
OTUB1_HUMAN No
PHF7_HUMAN No
PJA2_HUMAN No
Q6GX22_HUMAN No
Q8NEX1_HUMAN No
RBX2_HUMAN No
RFWD3_HUMAN No
RMD5B_HUMAN No
RN115_HUMAN Yes: Q9Y4L5 (MoonDB)
RN126_HUMAN No
RN150_HUMAN No
RN165_HUMAN No
RN166_HUMAN No
RN181_HUMAN No
RNF10_HUMAN No
RNF11_HUMAN No
RNF12_HUMAN No
RNF13_HUMAN No
RNF14_HUMAN No
RNF25_HUMAN No
RNF26_HUMAN No
RNF43_HUMAN No
SNURF_HUMAN No
TOPRS_HUMAN No
TRAF6_HUMAN Yes: Q9Y4K3 (MoonDB)
TRI10_HUMAN No
TRI25_HUMAN No
TRI45_HUMAN No
TRI62_HUMAN No
TRIM3_HUMAN No
TRIM8_HUMAN Yes: Q9BZR9 (MoonDB)
UBE4A_HUMAN No
UBTD1_HUMAN No
UFL1_HUMAN No
UFM1_HUMAN No
ZN363_HUMAN No
ZNFX1_HUMAN No
ZNRF1_HUMAN No
ZNRF2_HUMAN No
ZNRF4_HUMAN No
PMID Article Title
12690205 Human chromosome 7: DNA sequence and biology.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
SSF54495 SSF54495 SUPFAM
UBCc cd00195 CDD