Protein: Q9Y6K9

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y6K9 (Uniprot) NEMO_HUMAN IKBKG NF-kappa-B essential modulator human No
Uniprot: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0016070 RNA metabolic process 75 GO:0006464 cellular protein modification process 818 5.81e-04 8.44e-05
GO:0036211 protein modification process 106, 138 GO:0016070 RNA metabolic process 75 5.81e-04 8.44e-05
GO:0007165 signal transduction 141, 308 GO:0016070 RNA metabolic process 75 3.11e-78 2.75e-26
GO:0019538 protein metabolic process 665, 728 GO:0016070 RNA metabolic process 75 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
51 GO:0060255 regulation of macromolecule metabolic process
75 GO:0016071 mRNA metabolic process
75 GO:0051252 regulation of RNA metabolic process
75 GO:0010468 regulation of gene expression
75 GO:0006351 transcription, DNA-templated
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
124 GO:0010467 gene expression
124 GO:0090304 nucleic acid metabolic process
138 GO:0006464 cellular protein modification process
138 GO:0007165 signal transduction
141 GO:0035556 intracellular signal transduction
141 GO:0006468 protein phosphorylation
141 GO:0060255 regulation of macromolecule metabolic process
203 GO:0016070 RNA metabolic process
203 GO:0010468 regulation of gene expression
211 GO:0034645 cellular macromolecule biosynthetic process
211 GO:0044271 cellular nitrogen compound biosynthetic process
211 GO:0090304 nucleic acid metabolic process
211 GO:0060255 regulation of macromolecule metabolic process
281 GO:0060255 regulation of macromolecule metabolic process
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
373 GO:0034645 cellular macromolecule biosynthetic process
373 GO:0006139 nucleobase-containing compound metabolic process
373 GO:0060255 regulation of macromolecule metabolic process
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
473 GO:0060255 regulation of macromolecule metabolic process
473 GO:0007165 signal transduction
513 GO:0007165 signal transduction
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
629 GO:0007165 signal transduction
665 GO:0044267 cellular protein metabolic process
677 GO:0022607 cellular component assembly
685 GO:0060255 regulation of macromolecule metabolic process
685 GO:0007165 signal transduction
696 GO:0022607 cellular component assembly
696 GO:0006464 cellular protein modification process
696 GO:0060255 regulation of macromolecule metabolic process
696 GO:0007165 signal transduction
701 GO:0031327 negative regulation of cellular biosynthetic process
701 GO:0010558 negative regulation of macromolecule biosynthetic process
701 GO:0051172 negative regulation of nitrogen compound metabolic process
701 GO:0006357 regulation of transcription from RNA polymerase II promoter
701 GO:0007165 signal transduction
724 GO:0016070 RNA metabolic process
724 GO:0035556 intracellular signal transduction
724 GO:0009892 negative regulation of metabolic process
724 GO:0034654 nucleobase-containing compound biosynthetic process
724 GO:0006468 protein phosphorylation
724 GO:2000112 regulation of cellular macromolecule biosynthetic process
724 GO:0032268 regulation of cellular protein metabolic process
724 GO:0010468 regulation of gene expression
724 GO:0019219 regulation of nucleobase-containing compound metabolic process
728 GO:0044267 cellular protein metabolic process
728 GO:0031325 positive regulation of cellular metabolic process
728 GO:0010604 positive regulation of macromolecule metabolic process
728 GO:0051173 positive regulation of nitrogen compound metabolic process
728 GO:0051252 regulation of RNA metabolic process
728 GO:0010468 regulation of gene expression
728 GO:0007165 signal transduction
740 GO:0006355 regulation of transcription, DNA-templated
816 GO:0016070 RNA metabolic process
816 GO:0010467 gene expression
816 GO:0034654 nucleobase-containing compound biosynthetic process
816 GO:0010646 regulation of cell communication
816 GO:2000112 regulation of cellular macromolecule biosynthetic process
816 GO:0019219 regulation of nucleobase-containing compound metabolic process
816 GO:0023051 regulation of signaling
816 GO:0007165 signal transduction
818 GO:0070647 protein modification by small protein conjugation or removal
818 GO:0006355 regulation of transcription, DNA-templated
818 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
51 GO:0005634 nucleus
75 GO:0005829 cytosol
75 GO:0005654 nucleoplasm
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
124 GO:0031981 nuclear lumen
138 GO:0005634 nucleus
141 GO:0005634 nucleus
203 GO:0070013 intracellular organelle lumen
203 GO:0005634 nucleus
206 GO:0005829 cytosol
211 GO:0005829 cytosol
211 GO:0031981 nuclear lumen
260 GO:0005829 cytosol
281 GO:0005634 nucleus
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
317 GO:0005829 cytosol
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
473 GO:0005634 nucleus
513 GO:0005829 cytosol
513 GO:0005634 nucleus
549 GO:0005829 cytosol
549 GO:0005634 nucleus
567 GO:0005634 nucleus
629 GO:0005829 cytosol
629 GO:0031982 vesicle
665 GO:0043232 intracellular non-membrane-bounded organelle
665 GO:0005634 nucleus
677 GO:0005813 centrosome
677 GO:0005829 cytosol
677 GO:0005634 nucleus
685 GO:0005829 cytosol
696 GO:0005829 cytosol
696 GO:0043232 intracellular non-membrane-bounded organelle
696 GO:0005634 nucleus
701 GO:0005654 nucleoplasm
724 GO:0005829 cytosol
724 GO:0070013 intracellular organelle lumen
724 GO:0005634 nucleus
728 GO:0005829 cytosol
728 GO:0005634 nucleus
739 GO:0043232 intracellular non-membrane-bounded organelle
739 GO:0005654 nucleoplasm
740 GO:0070013 intracellular organelle lumen
740 GO:0005634 nucleus
816 GO:0005654 nucleoplasm
818 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000187 activation of MAPK activity TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0006351 transcription, DNA-templated IEA
GO:0006915 apoptotic process TAS
GO:0006954 inflammatory response TAS
GO:0006955 immune response TAS
GO:0006974 cellular response to DNA damage stimulus IMP
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
GO:0007254 JNK cascade TAS
GO:0009615 response to virus TAS
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
GO:0016032 viral process IEA
GO:0016239 positive regulation of macroautophagy ISS
GO:0016579 protein deubiquitination TAS
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
GO:0043276 anoikis ISS
GO:0045087 innate immune response TAS
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0050852 T cell receptor signaling pathway TAS
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
GO:0051403 stress-activated MAPK cascade TAS
GO:0051650 establishment of vesicle localization IMP
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:1901215 negative regulation of neuron death TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000151 ubiquitin ligase complex IPI
GO:0000922 spindle pole IDA
GO:0005622 intracellular IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0008385 IkappaB kinase complex TAS
GO:0072686 mitotic spindle IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PSA3_HUMAN Yes: P25788 (MoonDB)
ENKD1_HUMAN No
ZBTB3_HUMAN No
OSGI1_HUMAN No
TEANC_HUMAN No
IKBA_HUMAN No
SHOT1_HUMAN No
TNIP1_HUMAN No
ABCA1_HUMAN No
ACBD6_HUMAN No
ADAP2_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
AIP_HUMAN No
AKT1_HUMAN No
AMERL_HUMAN No
AR6P4_HUMAN No
ARGL1_HUMAN No
ARP19_HUMAN No
CACO2_HUMAN No
CALB1_HUMAN No
CAR10_HUMAN No
CASP6_HUMAN No
CBP_HUMAN No
CCHCR_HUMAN No
CDK2_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CETN3_HUMAN No
CLIC1_HUMAN No
CNOT7_HUMAN No
CS012_HUMAN No
CS057_HUMAN No
CSN3_HUMAN No
CTIP_HUMAN No
CUED1_HUMAN No
CYLD_HUMAN No
DAPK1_HUMAN No
DC1L1_HUMAN No
DD19B_HUMAN No
DDIT3_HUMAN No
DQA1_HUMAN No
EF1A1_HUMAN No
EGFR_HUMAN Yes: P00533 (MoonDB)
EPHA4_HUMAN No
FLT3_HUMAN No
FRMD8_HUMAN No
G45IP_HUMAN No
GA45G_HUMAN No
GCC1_HUMAN No
GCYA3_HUMAN No
GEMI2_HUMAN No
GFAP_HUMAN No
GIT2_HUMAN No
GLYG2_HUMAN No
GPKOW_HUMAN No
GRK4_HUMAN No
GSK3B_HUMAN No
H10_HUMAN No
HCLS1_HUMAN No
HDDC2_HUMAN No
HOIL1_HUMAN No
HPPD_HUMAN No
ID1_HUMAN No
ID3_HUMAN No
IKKB_HUMAN No
IN80E_HUMAN No
ITK_HUMAN No
JAK3_HUMAN No
K1C18_HUMAN No
K2C8_HUMAN No
KANL2_HUMAN No
KPCB_HUMAN No
KPCD3_HUMAN No
KPCI_HUMAN No
LC7L2_HUMAN No
LCK_HUMAN No
LENG8_HUMAN No
LGUL_HUMAN No
LMCD1_HUMAN No
LPXN_HUMAN No
LZIC_HUMAN No
LZTR1_HUMAN No
MAFIP_HUMAN No
MARE1_HUMAN No
MCM10_HUMAN No
MCM7_HUMAN No
MED7_HUMAN No
MPRIP_HUMAN No
MYL5_HUMAN No
MYO5C_HUMAN No
MZT2A_HUMAN No
NECA3_HUMAN No
NHP2_HUMAN No
NP1L5_HUMAN No
NRARP_HUMAN No
NRBF2_HUMAN No
NTM1A_HUMAN No
ODAM_HUMAN No
OSB10_HUMAN No
PA2G4_HUMAN No
PCKGC_HUMAN No
PHF7_HUMAN No
PHLP_HUMAN No
PIM2_HUMAN No
PKHJ1_HUMAN No
PNM8A_HUMAN No
PP2AA_HUMAN No
PRP18_HUMAN No
PSB5_HUMAN No
Q6P2C6_HUMAN No
RBM34_HUMAN No
RBM8A_HUMAN No
RBP1_HUMAN No
RBX2_HUMAN No
RET1_HUMAN No
RET_HUMAN No
RL41_HUMAN No
RNF11_HUMAN No
RNF4_HUMAN No
ROR2_HUMAN No
ROS1_HUMAN No
RPAB1_HUMAN No
RPAP3_HUMAN No
RPB2_HUMAN No
RPB4_HUMAN No
RPC1_HUMAN No
RS12_HUMAN No
SCLT1_HUMAN No
SENP2_HUMAN No
SEPT9_HUMAN No
SGK1_HUMAN No
SLU7_HUMAN No
SNW1_HUMAN No
SPT5H_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
STK25_HUMAN No
STX11_HUMAN No
SYT1_HUMAN No
T11L1_HUMAN No
T2EA_HUMAN No
TAB2_HUMAN No
TAF7_HUMAN No
TANK_HUMAN No
TARA_HUMAN No
TAXB1_HUMAN Yes: Q86VP1 (MoonDB)
TBCD7_HUMAN No
TBK1_HUMAN No
TCP11_HUMAN No
TCP1L_HUMAN No
TCTP_HUMAN No
TEC_HUMAN No
TFG_HUMAN Yes: Q92734 (MoonDB)
TIE2_HUMAN No
TMA16_HUMAN No
TNAP3_HUMAN No
TNIP2_HUMAN No
TRBP2_HUMAN No
TRI29_HUMAN No
TRI31_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TSLP_HUMAN No
TTYH2_HUMAN No
TYRO3_HUMAN No
UB2D4_HUMAN Yes: Q9Y2X8 (MoonDB)
UBC_HUMAN Yes: P0CG48 (MoonDB)
VAMP3_HUMAN No
VGFR3_HUMAN No
WDR5_HUMAN No
WWP1_HUMAN Yes: Q9H0M0 (MoonDB)
ZN587_HUMAN No
ZZZ3_HUMAN No
PMID Article Title
9751060 IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
9891086 IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.
9927690 Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.
10087442 Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28.
10364167 Role of adapter function in oncoprotein-mediated activation of NF-kappaB: human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma.
10839543 Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti.
10944468 cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.
11047757 A novel X-linked disorder of immune deficiency and hypohidrotic ectodermal dysplasia is allelic to incontinentia pigmenti and due to mutations in IKK-gamma (NEMO).
11064457 Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein.
11080499 Role of ikkgamma/nemo in assembly of the IkappaB kinase complex.
11224521 Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia.
11242109 X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappa B signaling.
11389905 Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions.
11418127 CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation.
11590134 A recurrent deletion in the ubiquitously expressed NEMO (IKK-gamma) gene accounts for the vast majority of incontinentia pigmenti mutations.
11971985 Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.
12045264 Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations.
12133833 Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
12612076 Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.
12657630 In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase.
12917691 The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
14651848 Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.
14695475 Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14754897 ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
15100680 The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation.
15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
15229184 Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation.
15356572 Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia.
15456791 PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15620648 The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.
15772651 The DNA sequence of the human X chromosome.
16360037 PIDD mediates NF-kappaB activation in response to DNA damage.
16497931 Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.
16547522 Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation.
16818673 X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production.
16950813 IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease.
17135271 Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.
17728323 Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.
17977820 Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.
18079694 A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
18164680 Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347.
18313693 Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation.
18462684 Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19033441 The zinc finger of NEMO is a functional ubiquitin-binding domain.
19136968 Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
19185524 Structural basis for recognition of diubiquitins by NEMO.
19854139 Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.
19854204 DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding.
20010814 A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20434027 NEMO gene mutations in Chinese patients with incontinentia pigmenti.
20724660 Polyubiquitin conjugation to NEMO by tripartite motif protein 23 (TRIM23) is critical in antiviral defense.
21269460 Initial characterization of the human central proteome.
21455173 Linear ubiquitination prevents inflammation and regulates immune signalling.
21455180 SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.
21455181 SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis.
21474709 TRIM40 promotes neddylation of IKKgamma and is downregulated in gastrointestinal cancers.
21606507 Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.
22099304 Direct, noncatalytic mechanism of IKK inhibition by A20.
22672233 NLRP10 enhances Shigella-induced pro-inflammatory responses.
23453969 IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
24012789 Identifying post-translational modifications of NEMO by tandem mass spectrometry after high affinity purification.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24339369 Insight into IKBKG/NEMO locus: report of new mutations and complex genomic rearrangements leading to incontinentia pigmenti disease.
25861989 TRAF family member-associated NF-kappaB activator (TANK) inhibits genotoxic nuclear factor kappaB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase.
26334375 IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).
28490597 Molluscum contagiosum virus protein MC005 inhibits NF-kappaB activation by targeting NEMO-regulated IkappaB kinase activation.
OMIM ID Disease Name
300291 Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked
300301 Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema
300584 Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia
300636 Immunodeficiency 33
300640 Recurrent isolated invasive pneumococcal disease 2
Domain Name Domain ID Source
NEMO_N IPR021063 InterPro
CC2-LZ_dom IPR032419 InterPro
NEMO_ZF IPR034735 InterPro
NEMO PF11577 Pfam
CC2-LZ PF16516 Pfam
ZF_CCHC_NOA PS51801 PROSITE