Protein: Q92734

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q92734 (Uniprot) TFG_HUMAN TFG Protein TFG human No
Uniprot: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 GO:0019538 protein metabolic process 578 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
51 GO:0060255 regulation of macromolecule metabolic process
403 GO:0060255 regulation of macromolecule metabolic process
450 GO:0051252 regulation of RNA metabolic process
450 GO:0010646 regulation of cell communication
450 GO:2000112 regulation of cellular macromolecule biosynthetic process
450 GO:0010468 regulation of gene expression
450 GO:0023051 regulation of signaling
450 GO:0007165 signal transduction
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
578 GO:0044267 cellular protein metabolic process
578 GO:0031325 positive regulation of cellular metabolic process
578 GO:0010604 positive regulation of macromolecule metabolic process
578 GO:0051173 positive regulation of nitrogen compound metabolic process
578 GO:0048584 positive regulation of response to stimulus
578 GO:0009966 regulation of signal transduction
578 GO:0006355 regulation of transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
51 GO:0005634 nucleus
60 GO:0005634 nucleus
402 GO:0005829 cytosol
403 GO:0005634 nucleus
450 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
578 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006888 ER to Golgi vesicle-mediated transport IMP
GO:0007165 signal transduction IEA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
GO:0048208 COPII vesicle coating TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000139 Golgi membrane IEA
GO:0005737 cytoplasm NAS
GO:0005829 cytosol TAS
GO:0070062 extracellular exosome IDA
GO:0070971 endoplasmic reticulum exit site IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7565764 The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.
9169129 Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
16959974 The consensus coding sequences of human breast and colorectal cancers.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21269460 Initial characterization of the human central proteome.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22883144 The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23479643 Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
27492651 Novel genetic, clinical, and pathomechanistic insights into TFG-associated hereditary spastic paraplegia.
27813252 The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein.
OMIM ID Disease Name
604484 Neuropathy, hereditary motor and sensory, Okinawa type
615658 Spastic paraplegia 57, autosomal recessive
Domain Name Domain ID Source
PB1_dom IPR000270 InterPro
TFG IPR033512 InterPro
PB1_TFG IPR034857 InterPro
PB1 PF00564 Pfam
PB1 PS51745 PROSITE
PTHR15335 PTHR15335 PANTHER
PB1 SM00666 SMART
PB1_TFG cd06401 CDD