Protein: Q92734 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q92734 (Uniprot)	TFG_HUMAN	TFG	Protein TFG	human	No

Protein Function

Uniprot: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	GO:0019538	protein metabolic process	578	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
403	GO:0060255	regulation of macromolecule metabolic process
450	GO:0051252	regulation of RNA metabolic process
450	GO:0010646	regulation of cell communication
450	GO:2000112	regulation of cellular macromolecule biosynthetic process
450	GO:0010468	regulation of gene expression
450	GO:0023051	regulation of signaling
450	GO:0007165	signal transduction
467	GO:0000398	mRNA splicing, via spliceosome
467	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
51	GO:0005634	nucleus
60	GO:0005634	nucleus
402	GO:0005829	cytosol
403	GO:0005634	nucleus
450	GO:0005634	nucleus
467	GO:0005654	nucleoplasm
578	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 4 of 4 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006888	ER to Golgi vesicle-mediated transport	IMP
GO:0007165	signal transduction	IEA
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP
GO:0048208	COPII vesicle coating	TAS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000139	Golgi membrane	IEA
GO:0005737	cytoplasm	NAS
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	IDA
GO:0070971	endoplasmic reticulum exit site	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 64 entries

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Interactor	Also a MoonDB EMF protein
ANX11_HUMAN	No
ARHGG_HUMAN	No
ARL15_HUMAN	No
BOLL_HUMAN	No
BPIA1_HUMAN	No
CE126_HUMAN	No
CEP55_HUMAN	No
CF218_HUMAN	No
CREST_HUMAN	No
CRX_HUMAN	No

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Publications Associated

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PMID	Article Title
7565764	The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain.
9169129	Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997	The DNA sequence, annotation and analysis of human chromosome 3.
16959974	The consensus coding sequences of human breast and colorectal cancers.
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21269460	Initial characterization of the human central proteome.

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OMIM Diseases Associated

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OMIM ID	Disease Name
604484	Neuropathy, hereditary motor and sensory, Okinawa type
615658	Spastic paraplegia 57, autosomal recessive

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Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
PB1	PF00564	Pfam
PB1	PS51745	PROSITE
PB1	SM00666	SMART
PB1_dom	IPR000270	InterPro
PB1_TFG	IPR034857	InterPro
PB1_TFG	cd06401	CDD
PTHR15335	PTHR15335	PANTHER
TFG	IPR033512	InterPro

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