Protein: Q9Y2D8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y2D8 (Uniprot) ADIP_HUMAN SSX2IP Afadin- and alpha-actinin-binding protein human No
Uniprot: Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 24 GO:0033036 macromolecule localization 748 4.56e-06 3.25e-28
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294 GO:0019538 protein metabolic process 665 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
36 GO:0022607 cellular component assembly
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
294 GO:0000398 mRNA splicing, via spliceosome
419 GO:0022607 cellular component assembly
513 GO:0007165 signal transduction
665 GO:0044267 cellular protein metabolic process
677 GO:0022607 cellular component assembly
686 GO:0060271 cilium assembly
748 GO:0008104 protein localization
764 GO:0022607 cellular component assembly
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
36 GO:0005829 cytosol
36 GO:0005815 microtubule organizing center
84 GO:0005634 nucleus
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
447 GO:0005829 cytosol
447 GO:0043232 intracellular non-membrane-bounded organelle
447 GO:0005634 nucleus
468 GO:0005634 nucleus
513 GO:0005829 cytosol
513 GO:0005634 nucleus
567 GO:0005634 nucleus
627 GO:0005634 nucleus
665 GO:0043232 intracellular non-membrane-bounded organelle
665 GO:0005634 nucleus
677 GO:0005813 centrosome
677 GO:0005829 cytosol
677 GO:0005634 nucleus
686 GO:0005813 centrosome
686 GO:0044441 ciliary part
686 GO:0005829 cytosol
686 GO:0044450 microtubule organizing center part
748 GO:0005815 microtubule organizing center
748 GO:0005634 nucleus
764 GO:0044430 cytoskeletal part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007098 centrosome cycle IMP
GO:0007155 cell adhesion IEA
GO:0035020 regulation of Rac protein signal transduction IEA
GO:0035735 intraciliary transport involved in cilium assembly IMP
GO:0060271 cilium assembly IMP
GO:2000145 regulation of cell motility IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005913 cell-cell adherens junction IEA
GO:0031252 cell leading edge IEA
GO:0034451 centriolar satellite IDA
GO:0036064 ciliary basal body IDA
GO:0043234 protein complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PRP31_HUMAN No
TFP11_HUMAN No
KR107_HUMAN No
ASPP2_HUMAN No
ZFY26_HUMAN No
ZN408_HUMAN No
K1C15_HUMAN No
TRI54_HUMAN No
CARD9_HUMAN No
CP135_HUMAN Yes: Q66GS9 (MoonDB)
HAUS1_HUMAN No
RBTN2_HUMAN No
AP1M1_HUMAN No
PSA1_HUMAN No
XIAP_HUMAN Yes: P98170 (MoonDB)
CC138_HUMAN No
ZGPAT_HUMAN No
ZBT24_HUMAN No
PRPF3_HUMAN No
BYST_HUMAN No
TRI42_HUMAN No
KAT5_HUMAN No
GEM_HUMAN No
NIF3L_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
CDA7L_HUMAN No
TRIP6_HUMAN No
K1H1_HUMAN No
TNIP1_HUMAN No
NDK7_HUMAN No
NEMO_HUMAN Yes: Q9Y6K9 (MoonDB)
K1C40_HUMAN No
CDC42_HUMAN Yes: P60953 (MoonDB)
MOS_HUMAN No
CCHCR_HUMAN No
FBF1_HUMAN No
FTM_HUMAN No
PKN1_HUMAN No
HDAC4_HUMAN No
FMR1_HUMAN No
ZN124_HUMAN No
F161A_HUMAN No
T10IP_HUMAN No
ZN648_HUMAN No
TTC23_HUMAN No
Q6PJG3_HUMAN No
Q8IVT4_HUMAN No
ZMAT2_HUMAN No
ZN587_HUMAN No
SCNM1_HUMAN No
BEX2_HUMAN No
DPOLL_HUMAN No
NAA10_HUMAN No
FRMD6_HUMAN No
WDR5_HUMAN No
KANK2_HUMAN No
RYDEN_HUMAN No
FANCL_HUMAN No
CE104_HUMAN No
PCM1_HUMAN Yes: Q15154 (MoonDB)
ODFP2_HUMAN No
CE162_HUMAN No
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
LCA5_HUMAN No
SPICE_HUMAN Yes: Q8N0Z3 (MoonDB)
CE120_HUMAN Yes: Q8N960 (MoonDB)
CEP63_HUMAN No
CEP89_HUMAN No
CDC23_HUMAN No
CEP55_HUMAN No
RINT1_HUMAN No
KDM1A_HUMAN Yes: O60341 (MoonDB)
CNOT1_HUMAN No
CENPJ_HUMAN No
1433T_HUMAN No
1433Z_HUMAN Yes: P63104 (MoonDB)
4ET_HUMAN No
AAPK1_HUMAN No
ABLM1_HUMAN No
ABLM3_HUMAN No
AEN_HUMAN No
AFAD_HUMAN No
AHI1_HUMAN No
AKTIP_HUMAN No
ANM6_HUMAN No
ARNT2_HUMAN No
ASPP1_HUMAN No
BRCA1_HUMAN No
C2D2A_HUMAN No
CAMP1_HUMAN No
CC85C_HUMAN No
CCNH_HUMAN No
CE290_HUMAN No
CE350_HUMAN No
CENPH_HUMAN No
CEP85_HUMAN No
CK054_HUMAN No
CKAP2_HUMAN No
CN105_HUMAN No
CNTRL_HUMAN No
CP131_HUMAN No
CS025_HUMAN No
CSPP1_HUMAN No
DAXX_HUMAN No
DHX35_HUMAN No
DRG1_HUMAN No
DVL1_HUMAN No
DVL2_HUMAN No
DVL3_HUMAN Yes: Q92997 (MoonDB)
ECH1_HUMAN No
ECHP_HUMAN No
ERAL1_HUMAN No
F120A_HUMAN No
F124B_HUMAN No
F214A_HUMAN No
FND11_HUMAN No
GOG8F_HUMAN No
GPTC1_HUMAN No
HAUS3_HUMAN No
HAUS4_HUMAN No
HAUS6_HUMAN No
HAUS8_HUMAN No
HOOK3_HUMAN No
IF4A2_HUMAN No
IFT74_HUMAN No
IN80B_HUMAN No
IPO8_HUMAN No
IRAK1_HUMAN No
K1671_HUMAN No
KIF7_HUMAN No
KIF9_HUMAN No
KLH42_HUMAN No
KTNA1_HUMAN No
KTNB1_HUMAN No
LATS1_HUMAN No
LIMD1_HUMAN No
LRC49_HUMAN No
LUZP1_HUMAN No
MA7D3_HUMAN No
MFAP1_HUMAN No
MIC19_HUMAN No
MOONR_HUMAN No
MORN4_HUMAN No
NDEL1_HUMAN Yes: Q9GZM8 (MoonDB)
NECD_HUMAN No
NEDD1_HUMAN No
NIN_HUMAN No
NOL12_HUMAN No
OCRL_HUMAN No
OFD1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PDLI5_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PIBF1_HUMAN No
PIMRE_HUMAN No
PKHG1_HUMAN No
POC5_HUMAN No
PTAR1_HUMAN No
PUR8_HUMAN No
Q32MN6_HUMAN No
RM53_HUMAN No
SAS6_HUMAN No
SC24B_HUMAN No
SDCG3_HUMAN No
SI1L2_HUMAN No
SMG7_HUMAN No
SSX2_HUMAN No
SSX3_HUMAN No
STIL_HUMAN No
SYT17_HUMAN No
TAB1_HUMAN Yes: Q15750 (MoonDB)
TBC31_HUMAN No
TBK1_HUMAN No
TBP_HUMAN No
TCHP_HUMAN No
TCPH_HUMAN No
TEAD4_HUMAN No
TNR6A_HUMAN No
TNR6B_HUMAN No
TNR6C_HUMAN No
TOP3B_HUMAN No
TPGS1_HUMAN No
TRI26_HUMAN No
TRI37_HUMAN No
TRIM9_HUMAN No
TTK_HUMAN No
TXLNG_HUMAN No
U2AFM_HUMAN No
VCIP1_HUMAN No
WAC2A_HUMAN No
WDR83_HUMAN No
WRP73_HUMAN No
XRN1_HUMAN Yes: Q8IZH2 (MoonDB)
ZN202_HUMAN No
ZN250_HUMAN No
ZN438_HUMAN No
ZN792_HUMAN No
ZN833_HUMAN No
ZNF3_HUMAN No
ZNF71_HUMAN No
ZSC12_HUMAN No
PMID Article Title
10231032 Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
12007189 The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16710414 The DNA sequence and biological annotation of human chromosome 1.
17686061 The leukaemia-associated antigen, SSX2IP, is expressed during mitosis on the surface of myeloid leukaemia cells.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19179477 Elevated expression of the leukemia-associated antigen SSX2IP predicts survival in acute myeloid leukemia patients who lack detectable cytogenetic rearrangements.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23816619 The centriolar satellite protein SSX2IP promotes centrosome maturation.
23826132 Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.
24356449 The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone.
26545777 The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.
No results found.
Domain Name Domain ID Source
Afadin/alpha-actinin-bd IPR021622 InterPro
ADIP PF11559 Pfam
T42649 T42649 PIR