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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q92997
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q92997 (Uniprot)
DVL3_HUMAN
DVL3
Segment polarity protein dishevelled homolog DVL-3
human
No
Protein Function
Uniprot:
May play a role in the signal transduction pathway mediated by multiple Wnt genes.
MoonDB Dissimilar Functions
Showing 1 to 4 of 4 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0016070
RNA metabolic process
689
GO:0033036
macromolecule localization
748
2.39e-09
2.36e-89
GO:0019538
protein metabolic process
194
GO:0016070
RNA metabolic process
689
5.15e-08
2.82e-13
GO:0034641
cellular nitrogen compound metabolic process
47
GO:0033036
macromolecule localization
748
4.14e-25
1.17e-53
GO:0044260
cellular macromolecule metabolic process
334
,
340
,
526
GO:0033036
macromolecule localization
748
4.56e-06
3.25e-28
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 39 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
47
GO:0044271
cellular nitrogen compound biosynthetic process
47
GO:0051252
regulation of RNA metabolic process
47
GO:0010468
regulation of gene expression
70
GO:0051252
regulation of RNA metabolic process
70
GO:0010468
regulation of gene expression
70
GO:0006351
transcription, DNA-templated
96
GO:0016070
RNA metabolic process
96
GO:0010467
gene expression
160
GO:0006355
regulation of transcription, DNA-templated
194
GO:0044267
cellular protein metabolic process
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Cellular Components
Showing 1 to 10 of 20 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
47
GO:0005654
nucleoplasm
70
GO:0005654
nucleoplasm
96
GO:0005654
nucleoplasm
117
GO:0005634
nucleus
160
GO:0005634
nucleus
194
GO:0043232
intracellular non-membrane-bounded organelle
194
GO:0031981
nuclear lumen
334
GO:0031981
nuclear lumen
340
GO:0005634
nucleus
402
GO:0005829
cytosol
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 16 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0001934
positive regulation of protein phosphorylation
IMP
GO:0016055
Wnt signaling pathway
IDA
GO:0035556
intracellular signal transduction
IEA
GO:0035567
non-canonical Wnt signaling pathway
IMP
GO:0038031
non-canonical Wnt signaling pathway via JNK cascade
ISS
GO:0042493
response to drug
IEA
GO:0043507
positive regulation of JUN kinase activity
IMP
GO:0043547
positive regulation of GTPase activity
IDA
GO:0045893
positive regulation of transcription, DNA-templated
IDA
GO:0050821
protein stabilization
IGI
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000790
nuclear chromatin
IDA
GO:0005829
cytosol
TAS
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 160 entries
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Interactor
Also a MoonDB EMF protein
AAPK2_HUMAN
No
ABT1_HUMAN
No
ADAP1_HUMAN
No
ADIP_HUMAN
Yes:
Q9Y2D8 (MoonDB)
AK17A_HUMAN
No
AL2SB_HUMAN
No
AN36B_HUMAN
No
AP3M1_HUMAN
No
BACD3_HUMAN
No
BAHD1_HUMAN
No
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Publications Associated
Showing 1 to 10 of 22 entries
Search:
PMID
Article Title
8817329
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.
9039502
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
9192851
Human dishevelled genes constitute a DHR-containing multigene family.
9344861
cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.
12805222
Regulation of the Wnt signaling pathway by disabled-2 (Dab2).
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15677333
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
16641997
The DNA sequence, annotation and analysis of human chromosome 3.
16959974
The consensus coding sequences of human breast and colorectal cancers.
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OMIM Diseases Associated
Showing 1 to 1 of 1 entries
Search:
OMIM ID
Disease Name
616894
Robinow syndrome, autosomal dominant 3
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Protein Domains Associated
Showing 1 to 10 of 31 entries
Search:
Domain Name
Domain ID
Source
DAX
SM00021
SMART
DEP
PF00610
Pfam
DEP
PS50186
PROSITE
DEP
SM00049
SMART
DEP_dom
IPR000591
InterPro
Dishevelled
PF02377
Pfam
DISHEVELLED
PR01760
PRINTS
DISHEVELLED3
PR01763
PRINTS
Dishevelled_C-dom
IPR024580
InterPro
Dishevelled_fam
IPR008339
InterPro
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