Protein: Q92997

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q92997 (Uniprot) DVL3_HUMAN DVL3 Segment polarity protein dishevelled homolog DVL-3 human No
Uniprot: May play a role in the signal transduction pathway mediated by multiple Wnt genes.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 47 GO:0033036 macromolecule localization 748 4.14e-25 1.17e-53
GO:0019538 protein metabolic process 194 GO:0016070 RNA metabolic process 689 5.15e-08 2.82e-13
GO:0044260 cellular macromolecule metabolic process 334, 340, 526 GO:0033036 macromolecule localization 748 4.56e-06 3.25e-28
GO:0016070 RNA metabolic process 689 GO:0033036 macromolecule localization 748 2.39e-09 2.36e-89
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
47 GO:0044271 cellular nitrogen compound biosynthetic process
47 GO:0051252 regulation of RNA metabolic process
47 GO:0010468 regulation of gene expression
70 GO:0051252 regulation of RNA metabolic process
70 GO:0010468 regulation of gene expression
70 GO:0006351 transcription, DNA-templated
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
160 GO:0006355 regulation of transcription, DNA-templated
194 GO:0044267 cellular protein metabolic process
194 GO:0006355 regulation of transcription, DNA-templated
334 GO:0016070 RNA metabolic process
334 GO:0010467 gene expression
334 GO:0060255 regulation of macromolecule metabolic process
340 GO:0016070 RNA metabolic process
340 GO:0010467 gene expression
340 GO:0060255 regulation of macromolecule metabolic process
478 GO:0060255 regulation of macromolecule metabolic process
526 GO:0016070 RNA metabolic process
526 GO:0034645 cellular macromolecule biosynthetic process
526 GO:0033554 cellular response to stress
526 GO:0034654 nucleobase-containing compound biosynthetic process
526 GO:0031325 positive regulation of cellular metabolic process
526 GO:0010604 positive regulation of macromolecule metabolic process
526 GO:0051173 positive regulation of nitrogen compound metabolic process
526 GO:0006468 protein phosphorylation
526 GO:0010468 regulation of gene expression
526 GO:0031399 regulation of protein modification process
526 GO:0009966 regulation of signal transduction
581 GO:0031326 regulation of cellular biosynthetic process
581 GO:0060255 regulation of macromolecule metabolic process
581 GO:0019219 regulation of nucleobase-containing compound metabolic process
581 GO:0006351 transcription, DNA-templated
646 GO:0060255 regulation of macromolecule metabolic process
646 GO:0006351 transcription, DNA-templated
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
748 GO:0008104 protein localization
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
47 GO:0005654 nucleoplasm
70 GO:0005654 nucleoplasm
96 GO:0005654 nucleoplasm
117 GO:0005634 nucleus
160 GO:0005634 nucleus
194 GO:0043232 intracellular non-membrane-bounded organelle
194 GO:0031981 nuclear lumen
334 GO:0031981 nuclear lumen
340 GO:0005634 nucleus
402 GO:0005829 cytosol
468 GO:0005634 nucleus
478 GO:0005634 nucleus
526 GO:0005829 cytosol
526 GO:0031981 nuclear lumen
581 GO:0005634 nucleus
646 GO:0005856 cytoskeleton
646 GO:0005634 nucleus
689 GO:0005654 nucleoplasm
748 GO:0005815 microtubule organizing center
748 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001934 positive regulation of protein phosphorylation IMP
GO:0016055 Wnt signaling pathway IDA
GO:0035556 intracellular signal transduction IEA
GO:0035567 non-canonical Wnt signaling pathway IMP
GO:0038031 non-canonical Wnt signaling pathway via JNK cascade ISS
GO:0042493 response to drug IEA
GO:0043507 positive regulation of JUN kinase activity IMP
GO:0043547 positive regulation of GTPase activity IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0050821 protein stabilization IGI
GO:0060070 canonical Wnt signaling pathway IMP
GO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS
GO:0090179 planar cell polarity pathway involved in neural tube closure IBA
GO:1903827 regulation of cellular protein localization IDA
GO:1904886 beta-catenin destruction complex disassembly TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PRP31_HUMAN No
CRTP1_HUMAN No
PR20D_HUMAN No
BEND7_HUMAN No
ENKD1_HUMAN No
ZN408_HUMAN No
VINEX_HUMAN No
TRAF2_HUMAN No
KLH12_HUMAN No
ZBT8A_HUMAN No
ZN837_HUMAN No
RBM39_HUMAN No
MMTA2_HUMAN No
PRR13_HUMAN No
CP135_HUMAN Yes: Q66GS9 (MoonDB)
MO4L1_HUMAN No
AP3M1_HUMAN No
ZN581_HUMAN No
PSME3_HUMAN No
CEP76_HUMAN No
ZBT24_HUMAN No
PRPF3_HUMAN No
TCEA2_HUMAN No
TEANC_HUMAN No
MB213_HUMAN No
GMCLL_HUMAN No
SYTL4_HUMAN No
ZN417_HUMAN Yes: Q8TAU3 (MoonDB)
CBX8_HUMAN No
PITX1_HUMAN No
PATZ1_HUMAN No
PPLA_HUMAN No
CEP19_HUMAN Yes: Q96LK0 (MoonDB)
STOM_HUMAN No
SYFM_HUMAN No
CE57L_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
CCNK_HUMAN No
WDR25_HUMAN No
GOR_HUMAN No
HOME3_HUMAN No
MAGB4_HUMAN No
AAPK2_HUMAN No
ZN124_HUMAN No
ZN648_HUMAN No
ZN774_HUMAN No
F90A1_HUMAN No
LNX1_HUMAN Yes: Q8TBB1 (MoonDB)
PRP18_HUMAN No
THAP7_HUMAN No
KLF3_HUMAN No
HXC8_HUMAN No
G45IP_HUMAN No
RYDEN_HUMAN No
ODFP2_HUMAN No
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
CE120_HUMAN Yes: Q8N960 (MoonDB)
LRRK2_HUMAN No
TFG_HUMAN Yes: Q92734 (MoonDB)
SUV91_HUMAN No
CENPJ_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
EIF3D_HUMAN No
ZN264_HUMAN No
ZN205_HUMAN No
ZN165_HUMAN No
ZN792_HUMAN No
ZN497_HUMAN No
ZN444_HUMAN No
BAHD1_HUMAN No
ZN764_HUMAN No
IN80B_HUMAN No
ZN696_HUMAN No
NXF1_HUMAN No
CEP44_HUMAN No
MGN2_HUMAN No
CLK1_HUMAN No
AK17A_HUMAN No
U2AFM_HUMAN No
ZN699_HUMAN No
SNIP1_HUMAN Yes: Q8TAD8 (MoonDB)
LUZP4_HUMAN No
WT1_HUMAN No
LONF1_HUMAN No
ABT1_HUMAN No
ADAP1_HUMAN No
AL2SB_HUMAN No
AN36B_HUMAN No
BACD3_HUMAN No
C2D2A_HUMAN No
CCNL1_HUMAN No
CDYL2_HUMAN No
CH033_HUMAN No
CT453_HUMAN No
CT45A_HUMAN No
DIDO1_HUMAN No
DPPA2_HUMAN No
DVL1_HUMAN No
EIF1B_HUMAN No
FA13C_HUMAN No
FGF11_HUMAN No
FGF16_HUMAN No
HXA5_HUMAN No
HXC5_HUMAN No
KAT7_HUMAN No
KAZRN_HUMAN No
KC1D_HUMAN No
KC1E_HUMAN No
KCTD7_HUMAN No
KLF15_HUMAN No
KLF4_HUMAN No
LENG8_HUMAN No
LY6H_HUMAN No
MATN2_HUMAN No
NFYA_HUMAN No
NKD1_HUMAN No
NOL12_HUMAN No
PHF19_HUMAN No
PK3CB_HUMAN No
PNKP_HUMAN No
PR38A_HUMAN No
PSMF1_HUMAN No
Q6FI91_HUMAN No
Q86TH3_HUMAN No
RB15B_HUMAN No
RL11_HUMAN No
RN151_HUMAN No
RRP8_HUMAN No
RS10_HUMAN No
RWD2B_HUMAN No
SAS10_HUMAN No
SNX22_HUMAN No
SP30L_HUMAN No
STIL_HUMAN No
STP1_HUMAN No
STP2_HUMAN No
SYT6_HUMAN No
TBPL1_HUMAN No
TNNT1_HUMAN No
TP8L1_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
TSN_HUMAN No
TSYL6_HUMAN No
TZAP_HUMAN No
VAX1_HUMAN No
XPA_HUMAN No
YTDC1_HUMAN No
Z512B_HUMAN No
ZBT26_HUMAN No
ZBT47_HUMAN No
ZFP57_HUMAN No
ZN319_HUMAN No
ZN697_HUMAN No
ZN775_HUMAN No
ZN821_HUMAN No
ZNF2_HUMAN No
ZNF71_HUMAN No
ZSC21_HUMAN No
ZSC22_HUMAN No
ZSC25_HUMAN No
PMID Article Title
8817329 cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.
9039502 Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
9192851 Human dishevelled genes constitute a DHR-containing multigene family.
9344861 cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.
12805222 Regulation of the Wnt signaling pathway by disabled-2 (Dab2).
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15677333 Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis.
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
16959974 The consensus coding sequences of human breast and colorectal cancers.
18669648 A quantitative atlas of mitotic phosphorylation.
20227366 Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21422228 Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.
22612246 Delicate analysis of post-translational modifications on Dishevelled 3.
22863007 Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.
23150776 Dishevelled3 is a novel arginine methyl transferase substrate.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25557784 DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
25805136 FOXKs promote Wnt/beta-catenin signaling by translocating DVL into the nucleus.
26924530 DVL3 alleles resulting in a -1 frameshift of the last exon mediate autosomal-dominant Robinow syndrome.
OMIM ID Disease Name
616894 Robinow syndrome, autosomal dominant 3
Domain Name Domain ID Source
DEP_dom IPR000591 InterPro
DIX IPR001158 InterPro
PDZ IPR001478 InterPro
Dishevelled_protein_dom IPR003351 InterPro
Dishevelled_fam IPR008339 InterPro
DVL3 IPR008342 InterPro
Dsh/Dvl-rel IPR015506 InterPro
Dishevelled_C-dom IPR024580 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
PDZ_sf IPR036034 InterPro
WH-like_DNA-bd_sf IPR036388 InterPro
WH_DNA-bd_sf IPR036390 InterPro
JC5763 JC5763 PIR
PDZ PF00595 Pfam
DEP PF00610 Pfam
DIX PF00778 Pfam
Dishevelled PF02377 Pfam
Dsh_C PF12316 Pfam
DISHEVELLED PR01760 PRINTS
DISHEVELLED3 PR01763 PRINTS
PDZ PS50106 PROSITE
DEP PS50186 PROSITE
DIX PS50841 PROSITE
PTHR10878 PTHR10878 PANTHER
PTHR10878:SF6 PTHR10878:SF6 PANTHER
DAX SM00021 SMART
DEP SM00049 SMART
PDZ SM00228 SMART
SSF46785 SSF46785 SUPFAM
SSF50156 SSF50156 SUPFAM
SSF54236 SSF54236 SUPFAM