Protein: Q8N960

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8N960 (Uniprot) CE120_HUMAN CEP120 Centrosomal protein of 120 kDa human No
Uniprot: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis (By similarity). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 57 GO:0033036 macromolecule localization 748 1.29e-20 6.46e-74
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
36 GO:0022607 cellular component assembly
57 GO:0006139 nucleobase-containing compound metabolic process
377 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
459 GO:0007165 signal transduction
469 GO:0060255 regulation of macromolecule metabolic process
748 GO:0008104 protein localization
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
36 GO:0005829 cytosol
36 GO:0005815 microtubule organizing center
57 GO:0005634 nucleus
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0005634 nucleus
377 GO:0005634 nucleus
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
459 GO:0005829 cytosol
459 GO:0043232 intracellular non-membrane-bounded organelle
459 GO:0005634 nucleus
469 GO:0043232 intracellular non-membrane-bounded organelle
469 GO:0005634 nucleus
631 GO:0044430 cytoskeletal part
631 GO:0005829 cytosol
631 GO:0015630 microtubule cytoskeleton
748 GO:0005815 microtubule organizing center
748 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007098 centrosome cycle ISS
GO:0010825 positive regulation of centrosome duplication ISS
GO:0021987 cerebral cortex development IEA
GO:0022008 neurogenesis IEA
GO:0022027 interkinetic nuclear migration IEA
GO:0030953 astral microtubule organization IEA
GO:0032880 regulation of protein localization IEA
GO:0045724 positive regulation of cilium assembly ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005813 centrosome IDA
GO:0005814 centriole ISS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15372022 The DNA sequence and comparative analysis of human chromosome 5.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17974005 The full-ORF clone resource of the German cDNA consortium.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25361962 A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies.
27208211 Mutations in CEP120 cause Joubert syndrome as well as complex ciliopathy phenotypes.
OMIM ID Disease Name
616300 Short-rib thoracic dysplasia 13 with or without polydactyly
Domain Name Domain ID Source
C2_dom IPR000008 InterPro
DUF3668 IPR022136 InterPro
C2_domain_sf IPR035892 InterPro
C2 PF00168 Pfam
DUF3668 PF12416 Pfam
SSF49562 SSF49562 SUPFAM