Protein: Q66GS9

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q66GS9 (Uniprot) CP135_HUMAN CEP135 Centrosomal protein of 135 kDa human No
Uniprot: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 20 GO:0033036 macromolecule localization 748 2.48e-08 1.95e-27
GO:0043170 macromolecule metabolic process 20 GO:0051641 cellular localization 872 4.90e-06 1.31e-91
GO:0006725 cellular aromatic compound metabolic process 494, 585 GO:0033036 macromolecule localization 748 1.29e-20 6.46e-74
GO:0006725 cellular aromatic compound metabolic process 494, 585 GO:0051641 cellular localization 872 2.74e-17 6.15e-158
GO:0033036 macromolecule localization 748 GO:0009059 macromolecule biosynthetic process 797 2.32e-08 6.09e-30
GO:0009059 macromolecule biosynthetic process 797 GO:0051641 cellular localization 872 1.95e-13 6.68e-127
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
3 GO:0022607 cellular component assembly
3 GO:0060255 regulation of macromolecule metabolic process
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
36 GO:0022607 cellular component assembly
212 GO:0007165 signal transduction
223 GO:0022607 cellular component assembly
223 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
494 GO:0006139 nucleobase-containing compound metabolic process
585 GO:0006139 nucleobase-containing compound metabolic process
684 GO:0022402 cell cycle process
684 GO:0051640 organelle localization
748 GO:0008104 protein localization
764 GO:0022607 cellular component assembly
797 GO:0034645 cellular macromolecule biosynthetic process
797 GO:0060255 regulation of macromolecule metabolic process
835 GO:0022607 cellular component assembly
835 GO:0051640 organelle localization
872 GO:0051649 establishment of localization in cell
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
3 GO:0044430 cytoskeletal part
3 GO:0005829 cytosol
3 GO:0005634 nucleus
20 GO:0005886 plasma membrane
25 GO:0005829 cytosol
25 GO:0005634 nucleus
36 GO:0005829 cytosol
36 GO:0005815 microtubule organizing center
72 GO:0016021 integral component of membrane
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
223 GO:0005634 nucleus
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
494 GO:0005634 nucleus
585 GO:0031981 nuclear lumen
631 GO:0044430 cytoskeletal part
631 GO:0005829 cytosol
631 GO:0015630 microtubule cytoskeleton
684 GO:0005829 cytosol
684 GO:0005815 microtubule organizing center
748 GO:0005815 microtubule organizing center
748 GO:0005634 nucleus
764 GO:0044430 cytoskeletal part
797 GO:0043232 intracellular non-membrane-bounded organelle
797 GO:0005634 nucleus
830 GO:0005856 cytoskeleton
830 GO:0005829 cytosol
830 GO:0070013 intracellular organelle lumen
830 GO:0005634 nucleus
835 GO:0044430 cytoskeletal part
835 GO:0005829 cytosol
835 GO:0015630 microtubule cytoskeleton
835 GO:0005654 nucleoplasm
872 GO:0005829 cytosol
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0007099 centriole replication IMP
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
GO:0010457 centriole-centriole cohesion IMP
GO:0097711 ciliary basal body-plasma membrane docking TAS
GO:1902857 positive regulation of non-motile cilium assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005813 centrosome IDA
GO:0005814 centriole IDA
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
ASPP2_HUMAN No
A0A087WUI6_HUMAN No
1433F_HUMAN No
ADIP_HUMAN Yes: Q9Y2D8 (MoonDB)
AL3A2_HUMAN No
ALMS1_HUMAN No
B3KNS4_HUMAN No
BMI1_HUMAN No
C2CD3_HUMAN No
C2D1A_HUMAN No
CAMP1_HUMAN No
CATL2_HUMAN No
CC138_HUMAN No
CCD14_HUMAN No
CCD18_HUMAN No
CCD66_HUMAN No
CCD77_HUMAN No
CDK4_HUMAN No
CE120_HUMAN Yes: Q8N960 (MoonDB)
CE128_HUMAN Yes: Q6ZU80 (MoonDB)
CE152_HUMAN No
CE162_HUMAN No
CE170_HUMAN No
CE192_HUMAN No
CE350_HUMAN No
CEP44_HUMAN No
CEP55_HUMAN No
CEP72_HUMAN No
CEP85_HUMAN No
CEP95_HUMAN No
CEP97_HUMAN No
CP110_HUMAN No
CP131_HUMAN No
CSPP1_HUMAN No
CTND1_HUMAN No
CYLD_HUMAN No
DHE4_HUMAN No
DHX35_HUMAN No
DLG5_HUMAN No
DVL1_HUMAN No
DVL2_HUMAN No
DVL3_HUMAN Yes: Q92997 (MoonDB)
ECH1_HUMAN No
FA83B_HUMAN No
FA83H_HUMAN No
FOPNL_HUMAN No
FR1OP_HUMAN No
GEN_HUMAN No
GPTC1_HUMAN No
GRIP1_HUMAN No
GTPB1_HUMAN No
GYS1_HUMAN No
HAUS1_HUMAN No
HAUS3_HUMAN No
HAUS4_HUMAN No
HAUS6_HUMAN No
HAUS7_HUMAN No
HAUS8_HUMAN No
IBTK_HUMAN No
IFT74_HUMAN No
ISOC1_HUMAN No
K1671_HUMAN No
KC1A_HUMAN No
KEAP1_HUMAN No
KIF14_HUMAN No
KIF7_HUMAN No
KPCI_HUMAN No
LIS1_HUMAN No
LMO7_HUMAN No
LRC49_HUMAN No
LUZP1_HUMAN No
LZTS2_HUMAN No
LZTS3_HUMAN No
MA7D3_HUMAN No
MAGD1_HUMAN No
MCTS1_HUMAN No
MED4_HUMAN No
MIIP_HUMAN No
MOONR_HUMAN No
MPP9_HUMAN No
MTPN_HUMAN No
NAV1_HUMAN No
NBR1_HUMAN No
NCK5L_HUMAN No
NDE1_HUMAN No
NDEL1_HUMAN Yes: Q9GZM8 (MoonDB)
NDK7_HUMAN No
NEDD1_HUMAN No
NU155_HUMAN No
ODFP2_HUMAN No
OFD1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PCM1_HUMAN Yes: Q15154 (MoonDB)
PIBF1_HUMAN No
PKHG1_HUMAN No
PLK1_HUMAN Yes: P53350 (MoonDB)
PRC2B_HUMAN No
PRSR3_HUMAN No
PUR8_HUMAN No
RAB8A_HUMAN No
RB6I2_HUMAN No
RCOR1_HUMAN No
RHG21_HUMAN No
RTTN_HUMAN No
S23IP_HUMAN No
SAS6_HUMAN No
SDCG3_HUMAN No
SI1L1_HUMAN No
SI1L2_HUMAN No
SI1L3_HUMAN No
SMAD9_HUMAN No
SPA24_HUMAN No
SPA2L_HUMAN No
SPAT2_HUMAN No
SPICE_HUMAN Yes: Q8N0Z3 (MoonDB)
SQSTM_HUMAN Yes: Q13501 (MoonDB)
SRP72_HUMAN No
SRPK1_HUMAN Yes: Q96SB4 (MoonDB)
SYNEM_HUMAN No
TBC19_HUMAN No
TBC31_HUMAN No
TBK1_HUMAN No
TCHP_HUMAN No
TEX9_HUMAN No
TM160_HUMAN No
TM209_HUMAN No
TNIP1_HUMAN No
TNR6A_HUMAN No
TNR6B_HUMAN No
TPGS1_HUMAN No
TRIP6_HUMAN No
TTK_HUMAN No
TXLNA_HUMAN No
TXLNG_HUMAN No
UBP54_HUMAN No
VATB1_HUMAN No
WDR83_HUMAN No
WRP73_HUMAN No
XRN1_HUMAN Yes: Q8IZH2 (MoonDB)
YTHD1_HUMAN No
ZO1_HUMAN No
ZO2_HUMAN No
PMID Article Title
9734811 Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
14654843 Proteomic characterization of the human centrosome by protein correlation profiling.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17681131 Plk4-induced centriole biogenesis in human cells.
18851962 A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization.
22521416 A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
26675238 WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
OMIM ID Disease Name
614673 Microcephaly 8, primary, autosomal recessive
Domain Name Domain ID Source
Cep135 IPR026732 InterPro
PTHR23159:SF18 PTHR23159:SF18 PANTHER