Protein: Q66GS9 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q66GS9 (Uniprot)	CP135_HUMAN	CEP135	Centrosomal protein of 135 kDa	human	No

Protein Function

Uniprot: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesio more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	494, 585	GO:0033036	macromolecule localization	748	1.29e-20	6.46e-74
GO:0006725	cellular aromatic compound metabolic process	494, 585	GO:0051641	cellular localization	872	2.74e-17	6.15e-158
GO:0009059	macromolecule biosynthetic process	797	GO:0051641	cellular localization	872	1.95e-13	6.68e-127
GO:0033036	macromolecule localization	748	GO:0009059	macromolecule biosynthetic process	797	2.32e-08	6.09e-30
GO:0043170	macromolecule metabolic process	20	GO:0033036	macromolecule localization	748	2.48e-08	1.95e-27
GO:0043170	macromolecule metabolic process	20	GO:0051641	cellular localization	872	4.90e-06	1.31e-91

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
3	GO:0022607	cellular component assembly
3	GO:0060255	regulation of macromolecule metabolic process
20	GO:0019538	protein metabolic process
20	GO:0007165	signal transduction
25	GO:0006464	cellular protein modification process
25	GO:0010467	gene expression
25	GO:0060255	regulation of macromolecule metabolic process
25	GO:0007165	signal transduction
36	GO:0022607	cellular component assembly
212	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
3	GO:0044430	cytoskeletal part
3	GO:0005829	cytosol
3	GO:0005634	nucleus
20	GO:0005886	plasma membrane
25	GO:0005829	cytosol
25	GO:0005634	nucleus
36	GO:0005829	cytosol
36	GO:0005815	microtubule organizing center
72	GO:0016021	integral component of membrane
190	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000086	G2/M transition of mitotic cell cycle	TAS
GO:0007099	centriole replication	IMP
GO:0010389	regulation of G2/M transition of mitotic cell cycle	TAS
GO:0010457	centriole-centriole cohesion	IMP
GO:0097711	ciliary basal body-plasma membrane docking	TAS
GO:1902857	positive regulation of non-motile cilium assembly	IMP

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005813	centrosome	IDA
GO:0005814	centriole	IDA
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433F_HUMAN	No
A0A087WUI6_HUMAN	No
ADIP_HUMAN	Yes: Q9Y2D8 (MoonDB)
AL3A2_HUMAN	No
ALMS1_HUMAN	No
ASPP2_HUMAN	No
B3KNS4_HUMAN	No
BMI1_HUMAN	No
C2CD3_HUMAN	No
C2D1A_HUMAN	No

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Publications Associated

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PMID	Article Title
9734811	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
14654843	Proteomic characterization of the human centrosome by protein correlation profiling.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17681131	Plk4-induced centriole biogenesis in human cells.
18851962	A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization.
22521416	A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.
26675238	WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614673	Microcephaly 8, primary, autosomal recessive

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Protein Domains Associated

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Domain Name	Domain ID	Source
Cep135	IPR026732	InterPro
PTHR23159:SF18	PTHR23159:SF18	PANTHER

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