Protein: O14503 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O14503 (Uniprot)	BHE40_HUMAN	BHLHE40	Class E basic helix-loop-helix protein 40	human	No

Protein Function

Uniprot: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repres more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0036211	protein modification process	25, 26	GO:0006396	RNA processing	426	5.60e-03	3.14e-16

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
7	GO:0031324	negative regulation of cellular metabolic process
7	GO:0010605	negative regulation of macromolecule metabolic process
7	GO:0051172	negative regulation of nitrogen compound metabolic process
7	GO:0010604	positive regulation of macromolecule metabolic process
7	GO:0006357	regulation of transcription from RNA polymerase II promoter
25	GO:0006464	cellular protein modification process
25	GO:0010467	gene expression
25	GO:0060255	regulation of macromolecule metabolic process
25	GO:0007165	signal transduction
26	GO:0006464	cellular protein modification process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
7	GO:0005654	nucleoplasm
25	GO:0005829	cytosol
25	GO:0005634	nucleus
26	GO:0005654	nucleoplasm
60	GO:0005634	nucleus
89	GO:0005634	nucleus
209	GO:0005654	nucleoplasm
380	GO:0005634	nucleus
426	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0006351	transcription, DNA-templated	IEA
GO:0006355	regulation of transcription, DNA-templated	NAS
GO:0032922	circadian regulation of gene expression	IDA
GO:0043153	entrainment of circadian clock by photoperiod	ISS
GO:0043433	negative regulation of DNA binding transcription factor activity	IDA
GO:0045892	negative regulation of transcription, DNA-templated	IDA

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	NAS
GO:0005737	cytoplasm	IEA
GO:0016604	nuclear body	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 92 entries

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Interactor	Also a MoonDB EMF protein
2A5D_HUMAN	No
2A5E_HUMAN	No
2AAA_HUMAN	No
2AAB_HUMAN	No
AAMP_HUMAN	No
AAPK1_HUMAN	No
AES_HUMAN	Yes: Q08117 (MoonDB)
APH1A_HUMAN	No
ARIP4_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)

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Publications Associated

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PMID	Article Title
9240428	Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes.
11226878	Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2.
11278694	Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway.
12397359	Dec1 and Dec2 are regulators of the mammalian molecular clock.
14672706	A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
15193144	DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15560782	Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1.
18411297	DEC1 modulates the circadian phase of clock gene expression.
19786558	The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 12 entries

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Domain Name	Domain ID	Source
BHLH	PS50888	PROSITE
bHLH_dom	IPR011598	InterPro
Hairy_orange	PF07527	Pfam
HLH	PF00010	Pfam
HLH	SM00353	SMART
HLH	cd00083	CDD
HLH_DNA-bd_sf	IPR036638	InterPro
JC5547	JC5547	PIR
ORANGE	PS51054	PROSITE
ORANGE	SM00511	SMART

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