Protein: P68400 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P68400 (Uniprot)	CSK21_HUMAN	CSNK2A1	Casein kinase II subunit alpha	human	No

Protein Function

Uniprot: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	15, 706	GO:0016070	RNA metabolic process	75, 689	5.15e-08	2.82e-13
GO:0019538	protein metabolic process	15, 706	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	353, 467	1.88e-02	4.66e-37
GO:0036211	protein modification process	28, 674	GO:0016070	RNA metabolic process	75, 689	5.81e-04	8.44e-05

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
15	GO:0044267	cellular protein metabolic process
28	GO:0006464	cellular protein modification process
28	GO:0031324	negative regulation of cellular metabolic process
28	GO:0010605	negative regulation of macromolecule metabolic process
28	GO:0051172	negative regulation of nitrogen compound metabolic process
28	GO:0031325	positive regulation of cellular metabolic process
28	GO:0010604	positive regulation of macromolecule metabolic process
28	GO:0051173	positive regulation of nitrogen compound metabolic process
28	GO:0048584	positive regulation of response to stimulus
28	GO:0009966	regulation of signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
28	GO:0005829	cytosol
28	GO:0043232	intracellular non-membrane-bounded organelle
28	GO:0005654	nucleoplasm
47	GO:0005654	nucleoplasm
75	GO:0005829	cytosol
75	GO:0005654	nucleoplasm
81	GO:0005829	cytosol
81	GO:0031981	nuclear lumen
99	GO:0005654	nucleoplasm
107	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006351	transcription, DNA-templated	IEA
GO:0006355	regulation of transcription, DNA-templated	IEA
GO:0006457	protein folding	TAS
GO:0006468	protein phosphorylation	IDA
GO:0006656	phosphatidylcholine biosynthetic process	TAS
GO:0006915	apoptotic process	IEA
GO:0007049	cell cycle	IEA
GO:0007165	signal transduction	TAS
GO:0008284	positive regulation of cell proliferation	IDA
GO:0016055	Wnt signaling pathway	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IEA
GO:0005956	protein kinase CK2 complex	IDA
GO:0016580	Sin3 complex	IDA
GO:0016581	NuRD complex	IDA
GO:0031519	PcG protein complex	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A0A0C3SFZ9_HUMAN	No
A0A0C4DFT8_HUMAN	No
ACINU_HUMAN	No
AIP_HUMAN	No
AKAP8_HUMAN	No
ALKB5_HUMAN	No
AN32B_HUMAN	No
APC_HUMAN	No
AR6P4_HUMAN	No
ARMX3_HUMAN	No

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Publications Associated

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PMID	Article Title
2174700	Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.
2752008	Molecular cloning of the human casein kinase II alpha subunit.
7592773	Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.
8420794	Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.
11092945	Crystallization and preliminary characterization of crystals of human protein kinase CK2.
11239457	A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
11574463	Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
11704824	Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.
11780052	The DNA sequence and comparative analysis of human chromosome 20.
12393879	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

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OMIM Diseases Associated

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OMIM ID	Disease Name
617062	Okur-Chung neurodevelopmental syndrome

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Protein Domains Associated

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Domain Name	Domain ID	Source
A30319	A30319	PIR
Kinase-like_dom_sf	IPR011009	InterPro
Pkinase	PF00069	Pfam
Prot_kinase_dom	IPR000719	InterPro
PROTEIN_KINASE_ATP	PS00107	PROSITE
Protein_kinase_ATP_BS	IPR017441	InterPro
PROTEIN_KINASE_DOM	PS50011	PROSITE
PROTEIN_KINASE_ST	PS00108	PROSITE
S_TKc	SM00220	SMART
Ser/Thr_kinase_AS	IPR008271	InterPro

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