Protein: P67870

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P67870 (Uniprot) CSK2B_HUMAN CSNK2B Casein kinase II subunit beta human No
Uniprot: Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 25, 26, 28 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
GO:0006139 nucleobase-containing compound metabolic process 27, 463 GO:0007165 signal transduction 534 1.10e-111 5.07e-25
GO:0007165 signal transduction 534 GO:0016070 RNA metabolic process 689 3.11e-78 2.75e-26
GO:0019538 protein metabolic process 578 GO:0016070 RNA metabolic process 689 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
26 GO:0006464 cellular protein modification process
26 GO:0090304 nucleic acid metabolic process
26 GO:0010468 regulation of gene expression
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
28 GO:0006464 cellular protein modification process
28 GO:0031324 negative regulation of cellular metabolic process
28 GO:0010605 negative regulation of macromolecule metabolic process
28 GO:0051172 negative regulation of nitrogen compound metabolic process
28 GO:0031325 positive regulation of cellular metabolic process
28 GO:0010604 positive regulation of macromolecule metabolic process
28 GO:0051173 positive regulation of nitrogen compound metabolic process
28 GO:0048584 positive regulation of response to stimulus
28 GO:0009966 regulation of signal transduction
28 GO:0006355 regulation of transcription, DNA-templated
45 GO:0071495 cellular response to endogenous stimulus
45 GO:0071310 cellular response to organic substance
45 GO:0032270 positive regulation of cellular protein metabolic process
45 GO:0006468 protein phosphorylation
45 GO:0042325 regulation of phosphorylation
45 GO:0009966 regulation of signal transduction
51 GO:0060255 regulation of macromolecule metabolic process
94 GO:0006464 cellular protein modification process
94 GO:0060255 regulation of macromolecule metabolic process
116 GO:0019538 protein metabolic process
116 GO:0060255 regulation of macromolecule metabolic process
122 GO:0016070 RNA metabolic process
122 GO:0044271 cellular nitrogen compound biosynthetic process
122 GO:0006464 cellular protein modification process
122 GO:0031324 negative regulation of cellular metabolic process
122 GO:0010605 negative regulation of macromolecule metabolic process
122 GO:0051172 negative regulation of nitrogen compound metabolic process
122 GO:2000112 regulation of cellular macromolecule biosynthetic process
122 GO:0010468 regulation of gene expression
122 GO:0019219 regulation of nucleobase-containing compound metabolic process
122 GO:0007165 signal transduction
344 GO:0010467 gene expression
344 GO:0019538 protein metabolic process
344 GO:0060255 regulation of macromolecule metabolic process
344 GO:0007165 signal transduction
380 GO:0010467 gene expression
380 GO:0019538 protein metabolic process
380 GO:0060255 regulation of macromolecule metabolic process
463 GO:0090304 nucleic acid metabolic process
463 GO:0060255 regulation of macromolecule metabolic process
526 GO:0016070 RNA metabolic process
526 GO:0034645 cellular macromolecule biosynthetic process
526 GO:0033554 cellular response to stress
526 GO:0034654 nucleobase-containing compound biosynthetic process
526 GO:0031325 positive regulation of cellular metabolic process
526 GO:0010604 positive regulation of macromolecule metabolic process
526 GO:0051173 positive regulation of nitrogen compound metabolic process
526 GO:0006468 protein phosphorylation
526 GO:0010468 regulation of gene expression
526 GO:0031399 regulation of protein modification process
526 GO:0009966 regulation of signal transduction
534 GO:0007166 cell surface receptor signaling pathway
534 GO:0006464 cellular protein modification process
534 GO:0033554 cellular response to stress
534 GO:0010467 gene expression
534 GO:0006796 phosphate-containing compound metabolic process
534 GO:0060255 regulation of macromolecule metabolic process
534 GO:0009966 regulation of signal transduction
534 GO:0009628 response to abiotic stimulus
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
578 GO:0044267 cellular protein metabolic process
578 GO:0031325 positive regulation of cellular metabolic process
578 GO:0010604 positive regulation of macromolecule metabolic process
578 GO:0051173 positive regulation of nitrogen compound metabolic process
578 GO:0048584 positive regulation of response to stimulus
578 GO:0009966 regulation of signal transduction
578 GO:0006355 regulation of transcription, DNA-templated
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
25 GO:0005829 cytosol
25 GO:0005634 nucleus
26 GO:0005654 nucleoplasm
27 GO:0031981 nuclear lumen
28 GO:0005829 cytosol
28 GO:0043232 intracellular non-membrane-bounded organelle
28 GO:0005654 nucleoplasm
39 GO:0043232 intracellular non-membrane-bounded organelle
45 GO:0005829 cytosol
45 GO:0031981 nuclear lumen
45 GO:0005886 plasma membrane
51 GO:0005634 nucleus
116 GO:0005829 cytosol
116 GO:0070013 intracellular organelle lumen
116 GO:0005634 nucleus
122 GO:0005829 cytosol
122 GO:0043232 intracellular non-membrane-bounded organelle
122 GO:0005654 nucleoplasm
216 GO:0005829 cytosol
241 GO:0005829 cytosol
241 GO:0005634 nucleus
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
344 GO:0070013 intracellular organelle lumen
344 GO:0005634 nucleus
380 GO:0005634 nucleus
463 GO:0005654 nucleoplasm
526 GO:0005829 cytosol
526 GO:0031981 nuclear lumen
534 GO:0005829 cytosol
534 GO:0012505 endomembrane system
534 GO:0005654 nucleoplasm
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
578 GO:0005634 nucleus
689 GO:0005654 nucleoplasm
710 GO:0005829 cytosol
710 GO:0070013 intracellular organelle lumen
710 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006457 protein folding TAS
GO:0006656 phosphatidylcholine biosynthetic process TAS
GO:0007165 signal transduction TAS
GO:0008285 negative regulation of cell proliferation TAS
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IDA
GO:0016055 Wnt signaling pathway IEA
GO:0016236 macroautophagy TAS
GO:0018107 peptidyl-threonine phosphorylation IDA
GO:0032927 positive regulation of activin receptor signaling pathway IMP
GO:0033211 adiponectin-activated signaling pathway IDA
GO:0033574 response to testosterone IEA
GO:0043312 neutrophil degranulation TAS
GO:0043537 negative regulation of blood vessel endothelial cell migration IDA
GO:0043623 cellular protein complex assembly NAS
GO:0045859 regulation of protein kinase activity IEA
GO:0051101 regulation of DNA binding NAS
GO:0061154 endothelial tube morphogenesis IMP
GO:0097421 liver regeneration IEA
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000785 chromatin IEA
GO:0005576 extracellular region TAS
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0005929 cilium IEA
GO:0005956 protein kinase CK2 complex NAS
GO:0016363 nuclear matrix IEA
GO:0031519 PcG protein complex IDA
GO:0034774 secretory granule lumen TAS
GO:0070062 extracellular exosome IDA
GO:1904813 ficolin-1-rich granule lumen TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000785 chromatin GO:0005576 extracellular region 4.68e-06 8.78e-112
GO:0000785 chromatin GO:0005737 cytoplasm 2.75e-08 6.83e-23
GO:0000785 chromatin GO:0005886 plasma membrane 3.25e-35 5.24e-112
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0005929 cilium 1.92e-09 0.00e+00
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
BANP_HUMAN No
ASPP2_HUMAN No
COIL_HUMAN No
TRI54_HUMAN No
LMO4_HUMAN No
STK16_HUMAN No
NTAQ1_HUMAN Yes: Q96HA8 (MoonDB)
CSK21_HUMAN Yes: P68400 (MoonDB)
AP2D_HUMAN No
WWOX_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
PP1G_HUMAN Yes: P36873 (MoonDB)
PP1A_HUMAN Yes: P62136 (MoonDB)
GLIS2_HUMAN No
2A5D_HUMAN No
ZN410_HUMAN No
Q8IVT4_HUMAN No
HXB5_HUMAN No
G45IP_HUMAN No
PP2AA_HUMAN No
LRP5L_HUMAN No
2A5E_HUMAN No
2AAA_HUMAN No
2AAB_HUMAN No
AAKB2_HUMAN No
ABHD4_HUMAN No
ACHA4_HUMAN No
ACL6B_HUMAN No
ACTB_HUMAN No
ACTY_HUMAN No
ACVL1_HUMAN No
ADDA_HUMAN No
ADHX_HUMAN No
ANGP2_HUMAN No
ANR28_HUMAN No
AP2A_HUMAN No
AP2M1_HUMAN No
APLP1_HUMAN No
ARAF_HUMAN No
ARBK1_HUMAN No
ARP5_HUMAN No
ATGA1_HUMAN No
BACD2_HUMAN No
BAG6_HUMAN No
BCCIP_HUMAN No
BGAL_HUMAN No
BHE41_HUMAN No
BMAL1_HUMAN No
BRCA1_HUMAN No
BTF3_HUMAN No
C163A_HUMAN No
CAC1A_HUMAN No
CC115_HUMAN No
CCNH_HUMAN No
CD81_HUMAN No
CDK20_HUMAN No
CDKA1_HUMAN No
CENPB_HUMAN No
CF136_HUMAN No
CI114_HUMAN No
CIC_HUMAN No
CIPC_HUMAN No
CLOCK_HUMAN No
CO4A2_HUMAN No
CPNE7_HUMAN No
CREL2_HUMAN No
CRY1_HUMAN No
CSK22_HUMAN No
CSN3_HUMAN No
CSN7A_HUMAN No
DACT1_HUMAN No
DALD3_HUMAN No
DCOR_HUMAN No
DEC1_HUMAN No
DEN5A_HUMAN No
DNMT1_HUMAN No
DUX1_HUMAN No
EPS8_HUMAN No
ERCC8_HUMAN No
EZH2_HUMAN No
F264_HUMAN No
FAF1_HUMAN No
FBXL5_HUMAN No
FIBB_HUMAN No
FRIH_HUMAN No
FXL15_HUMAN No
GAMT_HUMAN No
GBP2_HUMAN No
GNB5_HUMAN No
GSK3B_HUMAN No
HEXB_HUMAN No
HIRP3_HUMAN No
HTRA1_HUMAN No
IF2B_HUMAN No
IF2M_HUMAN No
IF6_HUMAN No
IN80B_HUMAN No
INT11_HUMAN No
IR3IP_HUMAN No
ITSN1_HUMAN No
KC1E_HUMAN No
KDM6B_HUMAN No
KIF2C_HUMAN No
KS6A2_HUMAN No
KS6A3_HUMAN No
KS6A5_HUMAN No
KS6B2_HUMAN No
LCK_HUMAN No
LEPR_HUMAN No
LYN_HUMAN No
LYST_HUMAN No
MAPK2_HUMAN No
MBD4_HUMAN No
MOXD1_HUMAN No
MPP2_HUMAN No
NCF1_HUMAN No
NMT2_HUMAN No
NOTC3_HUMAN No
NP1L1_HUMAN No
NPAS2_HUMAN No
NRBP_HUMAN No
OGA_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PACS1_HUMAN No
PCCB_HUMAN No
PDS5A_HUMAN No
PER1_HUMAN No
PER2_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PHF11_HUMAN No
PHRF1_HUMAN No
PIPNA_HUMAN No
PLXA3_HUMAN No
POTE1_HUMAN Yes: Q9NUX5 (MoonDB)
PP1B_HUMAN No
PP2BC_HUMAN No
PPID_HUMAN No
PROC_HUMAN No
PTPRK_HUMAN No
PYRD2_HUMAN No
RAD51_HUMAN No
RBX2_HUMAN No
RENT1_HUMAN No
RFA1_HUMAN No
RFC1_HUMAN No
RL13_HUMAN No
RL5_HUMAN No
RN126_HUMAN No
RORB_HUMAN No
RXRA_HUMAN Yes: P19793 (MoonDB)
SARNP_HUMAN No
SC11A_HUMAN No
SDHA_HUMAN No
SEN54_HUMAN No
SHAN3_HUMAN No
SIMC1_HUMAN No
SIR1_HUMAN No
SNX2_HUMAN No
SPSB3_HUMAN No
STA5A_HUMAN No
STAU1_HUMAN No
SUMO2_HUMAN No
SYNE4_HUMAN No
TBB2B_HUMAN No
TC1D2_HUMAN No
TCAL7_HUMAN No
TLE1_HUMAN No
TOP2B_HUMAN No
TRIB3_HUMAN No
UB2R1_HUMAN No
UT14A_HUMAN No
VDAC1_HUMAN No
VRK3_HUMAN No
WDR18_HUMAN No
WDR1_HUMAN No
WFKN1_HUMAN No
ZN784_HUMAN No
ZNF44_HUMAN No
ZNF71_HUMAN No
ZNHI1_HUMAN No
PMID Article Title
1694965 Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.
1856204 Structure of the gene encoding human casein kinase II subunit beta.
2300566 Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.
2513884 Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.
2666134 Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta.
10357806 Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.
11239457 A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
11298324 Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.
11574463 Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
11964394 Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.
12102635 Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.
12393879 p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.
14574404 The DNA sequence and analysis of human chromosome 6.
14656967 Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16818610 Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19369195 Large-scale proteomics analysis of the human kinome.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
A39459 A39459 PIR
Casein_kinase_II_reg-sub IPR000704 InterPro
Casein_kin_II_reg-sub_N IPR016149 InterPro
Casein_kinase_II_beta_like IPR035991 InterPro
CK_II_beta PF01214 Pfam
CASNKINASEII PR00472 PRINTS
CK2_BETA PS01101 PROSITE
PTHR11740 PTHR11740 PANTHER
CK_II_beta SM01085 SMART
SSF57798 SSF57798 SUPFAM