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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q9NUX5
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9NUX5 (Uniprot)
POTE1_HUMAN
POT1
Protection of telomeres protein 1
human
No
Protein Function
Uniprot:
Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded t
elomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.
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MoonDB Dissimilar Functions
Showing 1 to 3 of 3 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
1
GO:0006725
cellular aromatic compound metabolic process
57
,
239
,
342
,
345
,
614
5.44e-126
5.27e-27
GO:0007165
signal transduction
1
GO:0034641
cellular nitrogen compound metabolic process
245
,
477
4.22e-144
6.90e-18
GO:0007165
signal transduction
1
GO:0006139
nucleobase-containing compound metabolic process
405
,
860
1.10e-111
5.07e-25
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 71 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
1
GO:0035556
intracellular signal transduction
1
GO:0032268
regulation of cellular protein metabolic process
1
GO:0043067
regulation of programmed cell death
1
GO:0009966
regulation of signal transduction
38
GO:0007165
signal transduction
57
GO:0006139
nucleobase-containing compound metabolic process
211
GO:0034645
cellular macromolecule biosynthetic process
211
GO:0044271
cellular nitrogen compound biosynthetic process
211
GO:0090304
nucleic acid metabolic process
211
GO:0060255
regulation of macromolecule metabolic process
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5
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8
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Cellular Components
Showing 1 to 10 of 59 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
1
GO:0005829
cytosol
1
GO:0005634
nucleus
11
GO:0005634
nucleus
34
GO:0005634
nucleus
57
GO:0005634
nucleus
105
GO:0005634
nucleus
143
GO:0005634
nucleus
211
GO:0005829
cytosol
211
GO:0031981
nuclear lumen
217
GO:0005829
cytosol
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 15 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0007004
telomere maintenance via telomerase
IDA
GO:0016233
telomere capping
TAS
GO:0032202
telomere assembly
IDA
GO:0032210
regulation of telomere maintenance via telomerase
IGI
GO:0032211
negative regulation of telomere maintenance via telomerase
TAS
GO:0032212
positive regulation of telomere maintenance via telomerase
IDA
GO:0032508
DNA duplex unwinding
IDA
GO:0051096
positive regulation of helicase activity
IDA
GO:0051973
positive regulation of telomerase activity
IDA
GO:0051974
negative regulation of telomerase activity
IDA
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Cellular Components
Showing 1 to 6 of 6 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000781
chromosome, telomeric region
IDA
GO:0000783
nuclear telomere cap complex
IDA
GO:0000784
nuclear chromosome, telomeric region
IDA
GO:0005634
nucleus
IDA
GO:0005654
nucleoplasm
TAS
GO:0070187
shelterin complex
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 162 entries
Search:
Interactor
Also a MoonDB EMF protein
1433E_HUMAN
Yes:
P62258 (MoonDB)
1433G_HUMAN
No
3BP1_HUMAN
No
3HAO_HUMAN
No
6PGL_HUMAN
No
ACD_HUMAN
Yes:
Q96AP0 (MoonDB)
ACTB_HUMAN
No
ACTN4_HUMAN
No
ACY1_HUMAN
No
AF1L2_HUMAN
No
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Publications Associated
Showing 1 to 10 of 20 entries
Search:
PMID
Article Title
11349150
Pot1, the putative telomere end-binding protein in fission yeast and humans.
12391173
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.
12768206
POT1 as a terminal transducer of TRF1 telomere length control.
12781132
Human POT1 facilitates telomere elongation by telomerase.
12853948
The DNA sequence of human chromosome 7.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
14715659
DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites.
15231715
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
15316005
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
15383534
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
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OMIM Diseases Associated
Showing 1 to 2 of 2 entries
Search:
OMIM ID
Disease Name
615848
Melanoma, cutaneous malignant 10
616568
Glioma 9
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Protein Domains Associated
Showing 1 to 10 of 10 entries
Search:
Domain Name
Domain ID
Source
NA-bd_OB-fold
IPR012340
InterPro
POT1
IPR028389
InterPro
POT1
PF02765
Pfam
POT1PC
IPR032042
InterPro
POT1PC
PF16686
Pfam
PTHR14513
PTHR14513
PANTHER
SSF50249
SSF50249
SUPFAM
T08766
T08766
PIR
Telo_bind
SM00976
SMART
Telomer_end-bd_POT1/Cdc13
IPR011564
InterPro
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