Protein: Q8NEU8 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8NEU8 (Uniprot)	DP13B_HUMAN	APPL2	DCC-interacting protein 13-beta	human	Yes

Protein Function

Uniprot: Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.

Dissimilar Functions Manual Curation

Function 1: Endocytic function. Links Rab5 to nuclear signal transduction. Condition: cytoplasm localisation.

Function 2: Nucleosome remodelling, transcription regulation. Condition: nuclear localisation.

Publications (PMID): 15016378, 15261672, 19686092, 19433865

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
93	GO:0034645	cellular macromolecule biosynthetic process
93	GO:0034654	nucleobase-containing compound biosynthetic process
93	GO:0019538	protein metabolic process
93	GO:0051252	regulation of RNA metabolic process
93	GO:0010468	regulation of gene expression
477	GO:0044271	cellular nitrogen compound biosynthetic process
477	GO:0090304	nucleic acid metabolic process
477	GO:1901362	organic cyclic compound biosynthetic process
477	GO:2000112	regulation of cellular macromolecule biosynthetic process
477	GO:0007165	signal transduction

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Cellular Components

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
93	GO:0005829	cytosol
93	GO:0005634	nucleus
477	GO:0005829	cytosol
477	GO:0070013	intracellular organelle lumen
477	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007049	cell cycle	IEA
GO:0007165	signal transduction	TAS
GO:0008283	cell proliferation	IDA

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IC
GO:0010008	endosome membrane	IDA
GO:0016581	NuRD complex	IDA
GO:0031901	early endosome membrane	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 2 of 2 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0010008	endosome membrane	1.38e-08	8.40e-30
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ATF3_HUMAN	No
CNMD_HUMAN	No
CQ082_HUMAN	No
CRADD_HUMAN	No
CRBN_HUMAN	No
CRLF3_HUMAN	No
DOK3_HUMAN	No
DP13A_HUMAN	Yes: Q9UKG1 (MoonDB)
EPMIP_HUMAN	No
KIFC3_HUMAN	No

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Publications Associated

Showing 1 to 6 of 6 entries

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PMID	Article Title
11431708	Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15016378	APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075	The finished DNA sequence of human chromosome 12.
22814378	N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
AH/BAR_dom_sf	IPR027267	InterPro
PH	PF00169	Pfam
PH	SM00233	SMART
PH-like_dom_sf	IPR011993	InterPro
PH_domain	IPR001849	InterPro
PH_DOMAIN	PS50003	PROSITE
PID	PF00640	Pfam
PID	PS01179	PROSITE
PTB	SM00462	SMART
PTB/PI_dom	IPR006020	InterPro

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