Protein: Q9BSI4

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9BSI4 (Uniprot) TINF2_HUMAN TINF2 TERF1-interacting nuclear factor 2 human No
Uniprot: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 211, 391 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
40 GO:0051276 chromosome organization
40 GO:0090304 nucleic acid metabolic process
40 GO:0060255 regulation of macromolecule metabolic process
47 GO:0044271 cellular nitrogen compound biosynthetic process
47 GO:0051252 regulation of RNA metabolic process
47 GO:0010468 regulation of gene expression
107 GO:0016070 RNA metabolic process
107 GO:0044267 cellular protein metabolic process
107 GO:0034654 nucleobase-containing compound biosynthetic process
107 GO:2000112 regulation of cellular macromolecule biosynthetic process
107 GO:0010468 regulation of gene expression
107 GO:0019219 regulation of nucleobase-containing compound metabolic process
107 GO:0007165 signal transduction
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
161 GO:0090304 nucleic acid metabolic process
178 GO:0060255 regulation of macromolecule metabolic process
178 GO:0007165 signal transduction
211 GO:0034645 cellular macromolecule biosynthetic process
211 GO:0044271 cellular nitrogen compound biosynthetic process
211 GO:0090304 nucleic acid metabolic process
211 GO:0060255 regulation of macromolecule metabolic process
218 GO:0060255 regulation of macromolecule metabolic process
237 GO:0022607 cellular component assembly
237 GO:0034645 cellular macromolecule biosynthetic process
237 GO:0044271 cellular nitrogen compound biosynthetic process
237 GO:0006464 cellular protein modification process
237 GO:0051649 establishment of localization in cell
237 GO:0010467 gene expression
237 GO:0031324 negative regulation of cellular metabolic process
237 GO:0010605 negative regulation of macromolecule metabolic process
237 GO:0051172 negative regulation of nitrogen compound metabolic process
237 GO:0090304 nucleic acid metabolic process
237 GO:0033365 protein localization to organelle
237 GO:0015031 protein transport
237 GO:0050790 regulation of catalytic activity
237 GO:0051128 regulation of cellular component organization
239 GO:0006139 nucleobase-containing compound metabolic process
242 GO:0022607 cellular component assembly
242 GO:0010605 negative regulation of macromolecule metabolic process
242 GO:0045934 negative regulation of nucleobase-containing compound metabolic process
242 GO:0009893 positive regulation of metabolic process
242 GO:2000112 regulation of cellular macromolecule biosynthetic process
242 GO:0010468 regulation of gene expression
242 GO:1903506 regulation of nucleic acid-templated transcription
242 GO:0007165 signal transduction
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
316 GO:0044267 cellular protein metabolic process
316 GO:0060255 regulation of macromolecule metabolic process
319 GO:0060255 regulation of macromolecule metabolic process
342 GO:0006139 nucleobase-containing compound metabolic process
342 GO:0060255 regulation of macromolecule metabolic process
391 GO:0034645 cellular macromolecule biosynthetic process
391 GO:0090304 nucleic acid metabolic process
391 GO:0034654 nucleobase-containing compound biosynthetic process
391 GO:0060255 regulation of macromolecule metabolic process
391 GO:0019219 regulation of nucleobase-containing compound metabolic process
393 GO:0044267 cellular protein metabolic process
405 GO:0090304 nucleic acid metabolic process
405 GO:0060255 regulation of macromolecule metabolic process
405 GO:0019219 regulation of nucleobase-containing compound metabolic process
477 GO:0044271 cellular nitrogen compound biosynthetic process
477 GO:0090304 nucleic acid metabolic process
477 GO:1901362 organic cyclic compound biosynthetic process
477 GO:2000112 regulation of cellular macromolecule biosynthetic process
477 GO:0007165 signal transduction
540 GO:0022607 cellular component assembly
614 GO:0006139 nucleobase-containing compound metabolic process
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
724 GO:0016070 RNA metabolic process
724 GO:0035556 intracellular signal transduction
724 GO:0009892 negative regulation of metabolic process
724 GO:0034654 nucleobase-containing compound biosynthetic process
724 GO:0006468 protein phosphorylation
724 GO:2000112 regulation of cellular macromolecule biosynthetic process
724 GO:0032268 regulation of cellular protein metabolic process
724 GO:0010468 regulation of gene expression
724 GO:0019219 regulation of nucleobase-containing compound metabolic process
761 GO:0031324 negative regulation of cellular metabolic process
761 GO:0010605 negative regulation of macromolecule metabolic process
761 GO:0051172 negative regulation of nitrogen compound metabolic process
761 GO:0090304 nucleic acid metabolic process
761 GO:0034654 nucleobase-containing compound biosynthetic process
761 GO:2000112 regulation of cellular macromolecule biosynthetic process
761 GO:0019219 regulation of nucleobase-containing compound metabolic process
786 GO:0044271 cellular nitrogen compound biosynthetic process
786 GO:0044267 cellular protein metabolic process
786 GO:0006139 nucleobase-containing compound metabolic process
786 GO:0060255 regulation of macromolecule metabolic process
860 GO:0090304 nucleic acid metabolic process
860 GO:0034654 nucleobase-containing compound biosynthetic process
860 GO:2000112 regulation of cellular macromolecule biosynthetic process
860 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
11 GO:0005634 nucleus
34 GO:0005634 nucleus
40 GO:0043232 intracellular non-membrane-bounded organelle
40 GO:0005654 nucleoplasm
47 GO:0005654 nucleoplasm
107 GO:0005829 cytosol
107 GO:0005654 nucleoplasm
125 GO:0005829 cytosol
125 GO:0005634 nucleus
143 GO:0005634 nucleus
161 GO:0005634 nucleus
178 GO:0005634 nucleus
211 GO:0005829 cytosol
211 GO:0031981 nuclear lumen
218 GO:0005634 nucleus
237 GO:0005829 cytosol
237 GO:0012505 endomembrane system
237 GO:0005615 extracellular space
237 GO:0043232 intracellular non-membrane-bounded organelle
237 GO:0070013 intracellular organelle lumen
237 GO:0044428 nuclear part
237 GO:0031982 vesicle
239 GO:0043232 intracellular non-membrane-bounded organelle
239 GO:0031981 nuclear lumen
242 GO:0043232 intracellular non-membrane-bounded organelle
242 GO:0070013 intracellular organelle lumen
242 GO:0005634 nucleus
271 GO:0005634 nucleus
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
316 GO:0005634 nucleus
317 GO:0005829 cytosol
319 GO:0005829 cytosol
319 GO:0005634 nucleus
342 GO:0012505 endomembrane system
342 GO:0044428 nuclear part
391 GO:0070013 intracellular organelle lumen
391 GO:0005634 nucleus
393 GO:0043232 intracellular non-membrane-bounded organelle
393 GO:0005634 nucleus
405 GO:0005829 cytosol
405 GO:0043232 intracellular non-membrane-bounded organelle
405 GO:0070013 intracellular organelle lumen
405 GO:0005634 nucleus
477 GO:0005829 cytosol
477 GO:0070013 intracellular organelle lumen
477 GO:0044428 nuclear part
540 GO:0005829 cytosol
540 GO:0043232 intracellular non-membrane-bounded organelle
540 GO:0005634 nucleus
614 GO:0005829 cytosol
614 GO:0005634 nucleus
628 GO:0005829 cytosol
628 GO:0070062 extracellular exosome
628 GO:0005634 nucleus
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
724 GO:0005829 cytosol
724 GO:0070013 intracellular organelle lumen
724 GO:0005634 nucleus
761 GO:0005654 nucleoplasm
786 GO:0005829 cytosol
786 GO:0005654 nucleoplasm
860 GO:0043232 intracellular non-membrane-bounded organelle
860 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0010836 negative regulation of protein ADP-ribosylation IDA
GO:0016233 telomere capping TAS
GO:0032202 telomere assembly IMP
GO:0032211 negative regulation of telomere maintenance via telomerase IMP
GO:0050680 negative regulation of epithelial cell proliferation IMP
GO:0070198 protein localization to chromosome, telomeric region IMP
GO:1904356 regulation of telomere maintenance via telomere lengthening IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000781 chromosome, telomeric region IDA
GO:0000783 nuclear telomere cap complex IDA
GO:0000784 nuclear chromosome, telomeric region IDA
GO:0005654 nucleoplasm TAS
GO:0010370 perinucleolar chromocenter IDA
GO:0016363 nuclear matrix IEA
GO:0016604 nuclear body IDA
GO:0070187 shelterin complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
BAG3_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
CHIP_HUMAN Yes: Q9UNE7 (MoonDB)
LASP1_HUMAN No
DCX_HUMAN No
NUDC_HUMAN No
SRC8_HUMAN Yes: Q14247 (MoonDB)
PEX5_HUMAN No
REM2_HUMAN No
NCDN_HUMAN No
POTE1_HUMAN Yes: Q9NUX5 (MoonDB)
MTR1B_HUMAN No
FKBP6_HUMAN No
BACH_HUMAN No
G3P_HUMAN Yes: P04406 (MoonDB)
DREB_HUMAN No
ST1C2_HUMAN No
RSSA_HUMAN No
IPO5_HUMAN No
EF1D_HUMAN No
CIP4_HUMAN No
ENOG_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
CLK3_HUMAN No
GNMT_HUMAN No
ACTB_HUMAN No
NUDC2_HUMAN No
KPCB_HUMAN No
GDIR1_HUMAN No
RGS14_HUMAN No
HXA3_HUMAN No
LKHA4_HUMAN No
TERF1_HUMAN No
SIAH2_HUMAN No
1433G_HUMAN No
IF4B_HUMAN No
KCD17_HUMAN No
PGM1_HUMAN No
TBL1X_HUMAN No
ANXA4_HUMAN No
NOL3_HUMAN No
CPNE3_HUMAN No
TBB5_HUMAN No
TBB4B_HUMAN No
DP13B_HUMAN Yes: Q8NEU8 (MoonDB)
ADA_HUMAN No
CCD43_HUMAN No
TRI16_HUMAN No
URP2_HUMAN No
LDHA_HUMAN No
UCHL1_HUMAN No
IPP2_HUMAN No
PGM2_HUMAN No
ANXA5_HUMAN No
MP2K3_HUMAN No
DPP3_HUMAN No
KCRB_HUMAN No
ACD_HUMAN Yes: Q96AP0 (MoonDB)
ANXA8_HUMAN No
ABC3F_HUMAN No
AF1L2_HUMAN No
AIPL1_HUMAN No
ANKY2_HUMAN No
ARI3B_HUMAN No
BIN2_HUMAN No
CALD1_HUMAN No
CCDC9_HUMAN No
CRBS_HUMAN No
DYR2_HUMAN No
F131B_HUMAN No
HNMT_HUMAN No
KAD1_HUMAN No
LEGL_HUMAN No
OR2H1_HUMAN No
PAGE2_HUMAN No
PFKAP_HUMAN No
PHP14_HUMAN No
PK1IP_HUMAN No
PP6R3_HUMAN No
SCRN2_HUMAN No
SYSC_HUMAN No
TAGL_HUMAN No
TERF2_HUMAN No
TISB_HUMAN No
TOM34_HUMAN No
TRI15_HUMAN Yes: Q9C019 (MoonDB)
TXD17_HUMAN No
VIPR1_HUMAN No
ZN790_HUMAN No
PMID Article Title
10581025 TIN2, a new regulator of telomere length in human cells.
12768206 POT1 as a terminal transducer of TRF1 telomere length control.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15231715 POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
15316005 TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
15383534 Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16166375 Shelterin: the protein complex that shapes and safeguards human telomeres.
16880378 A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
18202258 A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
18252230 TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita.
18669648 A quantitative atlas of mitotic phosphorylation.
19229133 A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix.
19279399 The long and short of it: a new isoform of TIN2 in the nuclear matrix.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
OMIM ID Disease Name
268130 Dyskeratosis congenita, autosomal dominant, 5
613990 Dyskeratosis congenita, autosomal dominant, 3
Domain Name Domain ID Source
TINF2_N IPR029400 InterPro
TINF2_N PF14973 Pfam
TIN2_N cd11657 CDD