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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q9BSI4
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q9BSI4 (Uniprot)
TINF2_HUMAN
TINF2
TERF1-interacting nuclear factor 2
human
No
Protein Function
Uniprot:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA dama
ge surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009056
catabolic process
125
GO:0009059
macromolecule biosynthetic process
211
,
391
6.37e-04
1.88e-40
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 101 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
40
GO:0051276
chromosome organization
40
GO:0090304
nucleic acid metabolic process
40
GO:0060255
regulation of macromolecule metabolic process
47
GO:0044271
cellular nitrogen compound biosynthetic process
47
GO:0051252
regulation of RNA metabolic process
47
GO:0010468
regulation of gene expression
107
GO:0016070
RNA metabolic process
107
GO:0044267
cellular protein metabolic process
107
GO:0034654
nucleobase-containing compound biosynthetic process
107
GO:2000112
regulation of cellular macromolecule biosynthetic process
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5
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11
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Cellular Components
Showing 1 to 10 of 67 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
11
GO:0005634
nucleus
34
GO:0005634
nucleus
40
GO:0043232
intracellular non-membrane-bounded organelle
40
GO:0005654
nucleoplasm
47
GO:0005654
nucleoplasm
107
GO:0005829
cytosol
107
GO:0005654
nucleoplasm
125
GO:0005829
cytosol
125
GO:0005634
nucleus
143
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 7 of 7 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0010836
negative regulation of protein ADP-ribosylation
IDA
GO:0016233
telomere capping
TAS
GO:0032202
telomere assembly
IMP
GO:0032211
negative regulation of telomere maintenance via telomerase
IMP
GO:0050680
negative regulation of epithelial cell proliferation
IMP
GO:0070198
protein localization to chromosome, telomeric region
IMP
GO:1904356
regulation of telomere maintenance via telomere lengthening
IMP
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Cellular Components
Showing 1 to 8 of 8 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000781
chromosome, telomeric region
IDA
GO:0000783
nuclear telomere cap complex
IDA
GO:0000784
nuclear chromosome, telomeric region
IDA
GO:0005654
nucleoplasm
TAS
GO:0010370
perinucleolar chromocenter
IDA
GO:0016363
nuclear matrix
IEA
GO:0016604
nuclear body
IDA
GO:0070187
shelterin complex
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 89 entries
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Interactor
Also a MoonDB EMF protein
1433G_HUMAN
No
ABC3F_HUMAN
No
ACD_HUMAN
Yes:
Q96AP0 (MoonDB)
ACTB_HUMAN
No
ADA_HUMAN
No
AF1L2_HUMAN
No
AIPL1_HUMAN
No
ANKY2_HUMAN
No
ANXA4_HUMAN
No
ANXA5_HUMAN
No
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Publications Associated
Showing 1 to 10 of 19 entries
Search:
PMID
Article Title
10581025
TIN2, a new regulator of telomere length in human cells.
12768206
POT1 as a terminal transducer of TRF1 telomere length control.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15231715
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
15316005
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
15383534
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16166375
Shelterin: the protein complex that shapes and safeguards human telomeres.
16880378
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
18202258
A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
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OMIM Diseases Associated
Showing 1 to 2 of 2 entries
Search:
OMIM ID
Disease Name
268130
Dyskeratosis congenita, autosomal dominant, 5
613990
Dyskeratosis congenita, autosomal dominant, 3
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Protein Domains Associated
Showing 1 to 3 of 3 entries
Search:
Domain Name
Domain ID
Source
TIN2_N
cd11657
CDD
TINF2_N
IPR029400
InterPro
TINF2_N
PF14973
Pfam
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