Protein: Q14247

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q14247 (Uniprot) SRC8_HUMAN CTTN Src substrate cortactin human No
Uniprot: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 405 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
284 GO:0009966 regulation of signal transduction
405 GO:0090304 nucleic acid metabolic process
405 GO:0060255 regulation of macromolecule metabolic process
405 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
405 GO:0005829 cytosol
405 GO:0043232 intracellular non-membrane-bounded organelle
405 GO:0070013 intracellular organelle lumen
405 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006886 intracellular protein transport IMP
GO:0006898 receptor-mediated endocytosis ISS
GO:0006930 substrate-dependent cell migration, cell extension IEA
GO:0030041 actin filament polymerization IEA
GO:0030516 regulation of axon extension ISS
GO:0030838 positive regulation of actin filament polymerization IMP
GO:0031532 actin cytoskeleton reorganization ISS
GO:0045987 positive regulation of smooth muscle contraction IMP
GO:0048041 focal adhesion assembly ISS
GO:0048812 neuron projection morphogenesis ISS
GO:0048870 cell motility ISS
GO:0061024 membrane organization TAS
GO:0097062 dendritic spine maintenance IEA
GO:0097581 lamellipodium organization ISS
GO:1903146 regulation of autophagy of mitochondrion IEA
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001726 ruffle ISS
GO:0002102 podosome IEA
GO:0005737 cytoplasm IDA
GO:0005794 Golgi apparatus IDA
GO:0005829 cytosol TAS
GO:0005856 cytoskeleton TAS
GO:0005884 actin filament IDA
GO:0005886 plasma membrane IDA
GO:0005905 clathrin-coated pit ISS
GO:0005925 focal adhesion IDA
GO:0005938 cell cortex IDA
GO:0008076 voltage-gated potassium channel complex IDA
GO:0030027 lamellipodium IDA
GO:0030426 growth cone ISS
GO:0030863 cortical cytoskeleton IDA
GO:0043197 dendritic spine IEA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0070062 extracellular exosome IDA
GO:1990023 mitotic spindle midzone IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005856 cytoskeleton GO:0043231 intracellular membrane-bounded organelle 3.21e-14 3.53e-300
GO:0005886 plasma membrane GO:0043231 intracellular membrane-bounded organelle 0.00e+00 3.79e-47
PMID Article Title
1532244 Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas.
8474448 The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites.
9722593 Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER.
12151401 Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.
12408982 Novel interaction of cortactin with endothelial cell myosin light chain kinase.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15561106 The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
15574754 Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16636290 Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17487921 Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
17959782 An essential role for cortactin in the modulation of the potassium channel Kv1.2.
18088087 Phosphoproteome of resting human platelets.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19146815 Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20861316 Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.
21269460 Initial characterization of the human central proteome.
21296879 The immunoinhibitory adapter protein SRC homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23144454 Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
A48063 A48063 PIR
SH3_domain IPR001452 InterPro
Hs1_Cortactin IPR003134 InterPro
Cortactin IPR015503 InterPro
Cortactin_SH3 IPR035716 InterPro
SH3-like_dom_sf IPR036028 InterPro
HS1_rep PF02218 Pfam
SH3_9 PF14604 Pfam
SH3DOMAIN PR00452 PRINTS
SH3 PS50002 PROSITE
CORTACTIN PS51090 PROSITE
PTHR10829:SF15 PTHR10829:SF15 PANTHER
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SH3_Cortactin cd11959 CDD