Skip to main content
A Database of Extreme Multifunctional and Moonlighting Proteins
Main navigation
Home
Browse
Downloads
Help
About
Protein: Q96AP0
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q96AP0 (Uniprot)
ACD_HUMAN
ACD
Adrenocortical dysplasia protein homolog
human
No
Protein Function
Uniprot:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA dama
ge surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
more..
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009056
catabolic process
125
GO:0009059
macromolecule biosynthetic process
211
,
273
,
391
,
551
6.37e-04
1.88e-40
Copy
Excel
CSV
PDF
Previous
1
Next
MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 76 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
40
GO:0051276
chromosome organization
40
GO:0090304
nucleic acid metabolic process
40
GO:0060255
regulation of macromolecule metabolic process
107
GO:0016070
RNA metabolic process
107
GO:0044267
cellular protein metabolic process
107
GO:0034654
nucleobase-containing compound biosynthetic process
107
GO:2000112
regulation of cellular macromolecule biosynthetic process
107
GO:0010468
regulation of gene expression
107
GO:0019219
regulation of nucleobase-containing compound metabolic process
107
GO:0007165
signal transduction
Copy
Excel
CSV
PDF
Previous
1
2
3
4
5
…
8
Next
Cellular Components
Showing 1 to 10 of 55 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
11
GO:0005634
nucleus
34
GO:0005634
nucleus
40
GO:0043232
intracellular non-membrane-bounded organelle
40
GO:0005654
nucleoplasm
107
GO:0005829
cytosol
107
GO:0005654
nucleoplasm
125
GO:0005829
cytosol
125
GO:0005634
nucleus
161
GO:0005634
nucleus
211
GO:0005829
cytosol
Copy
Excel
CSV
PDF
Previous
1
2
3
4
5
6
Next
Protein GO Annotations
Biological Processes
Showing 1 to 10 of 15 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000723
telomere maintenance
IDA
GO:0001501
skeletal system development
IEA
GO:0001655
urogenital system development
IEA
GO:0006886
intracellular protein transport
IMP
GO:0016233
telomere capping
TAS
GO:0030326
embryonic limb morphogenesis
IEA
GO:0031848
protection from non-homologous end joining at telomere
ISS
GO:0032202
telomere assembly
IMP
GO:0032211
negative regulation of telomere maintenance via telomerase
TAS
GO:0032212
positive regulation of telomere maintenance via telomerase
IDA
Copy
Excel
CSV
PDF
Previous
1
2
Next
Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000783
nuclear telomere cap complex
IDA
GO:0000784
nuclear chromosome, telomeric region
IDA
GO:0005654
nucleoplasm
TAS
GO:0016604
nuclear body
IDA
GO:0070187
shelterin complex
IDA
Copy
Excel
CSV
PDF
Previous
1
Next
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 64 entries
Search:
Interactor
Also a MoonDB EMF protein
1433E_HUMAN
Yes:
P62258 (MoonDB)
ABC3F_HUMAN
No
ACTB_HUMAN
No
ADPRH_HUMAN
No
AF1L2_HUMAN
No
AIPL1_HUMAN
No
ANKY2_HUMAN
No
ANXA8_HUMAN
No
BAG3_HUMAN
No
CHIP_HUMAN
Yes:
Q9UNE7 (MoonDB)
Copy
Excel
CSV
PDF
Previous
1
2
3
4
5
6
7
Next
Publications Associated
Showing 1 to 10 of 23 entries
Search:
PMID
Article Title
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15181449
PTOP interacts with POT1 and regulates its localization to telomeres.
15231715
POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.
15316005
TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.
15383534
Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15537664
Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator.
15616553
The sequence and analysis of duplication-rich human chromosome 16.
16166375
Shelterin: the protein complex that shapes and safeguards human telomeres.
16880378
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.
Copy
Excel
CSV
PDF
Previous
1
2
3
Next
OMIM Diseases Associated
Showing 1 to 2 of 2 entries
Search:
OMIM ID
Disease Name
616553
Dyskeratosis congenita, autosomal dominant, 6
616553
Dyskeratosis congenita, autosomal recessive, 7
Copy
Excel
CSV
PDF
Previous
1
Next
Protein Domains Associated
Showing 1 to 2 of 2 entries
Search:
Domain Name
Domain ID
Source
ACD
IPR028631
InterPro
PTHR14487
PTHR14487
PANTHER
Copy
Excel
CSV
PDF
Previous
1
Next