Protein: P50570 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P50570 (Uniprot)	DYN2_HUMAN	DNM2	Dynamin-2	human	Yes

Protein Function

Uniprot: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in parti more..

Dissimilar Functions Manual Curation

Function 1: GTPase involved in membrane scission, remodelling and cytokinesis.

Function 2: Mitosis, centromere cohesion. Condition: interaction with microtubules, located at the mitotic spindle.

Publications (PMID): 15048127

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 25 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
186	GO:0048468	cell development
186	GO:0007166	cell surface receptor signaling pathway
186	GO:0044267	cellular protein metabolic process
186	GO:0035556	intracellular signal transduction
186	GO:0030182	neuron differentiation
186	GO:0006796	phosphate-containing compound metabolic process
186	GO:0120036	plasma membrane bounded cell projection organization
186	GO:0060255	regulation of macromolecule metabolic process
186	GO:0009966	regulation of signal transduction
284	GO:0009966	regulation of signal transduction

Previous1 2 3Next

Cellular Components

Showing 1 to 10 of 10 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
186	GO:0005829	cytosol
186	GO:0005886	plasma membrane
186	GO:0031982	vesicle
284	GO:0005829	cytosol
284	GO:0005886	plasma membrane
305	GO:0005634	nucleus
450	GO:0005634	nucleus
682	GO:0005634	nucleus
684	GO:0005829	cytosol
684	GO:0005815	microtubule organizing center

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 42 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000086	G2/M transition of mitotic cell cycle	NAS
GO:0000266	mitochondrial fission	IBA
GO:0002031	G-protein coupled receptor internalization	IEA
GO:0003281	ventricular septum development	IEA
GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	IBA
GO:0006355	regulation of transcription, DNA-templated	NAS
GO:0006893	Golgi to plasma membrane transport	IEA
GO:0006897	endocytosis	NAS
GO:0006898	receptor-mediated endocytosis	ISS
GO:0006909	phagocytosis	IEA

Previous1 2 3 4 5Next

Cellular Components

Showing 1 to 10 of 26 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000139	Golgi membrane	TAS
GO:0001891	phagocytic cup	IEA
GO:0001917	photoreceptor inner segment	IEA
GO:0005634	nucleus	IEA
GO:0005768	endosome	IEA
GO:0005794	Golgi apparatus	IDA
GO:0005802	trans-Golgi network	IEA
GO:0005813	centrosome	IEA
GO:0005829	cytosol	TAS
GO:0005874	microtubule	IDA

Previous1 2 3Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 10 of 11 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000139	Golgi membrane	GO:0005634	nucleus	1.09e-30	1.17e-81
GO:0005634	nucleus	GO:0005768	endosome	4.09e-12	7.34e-15
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0005802	trans-Golgi network	6.33e-05	3.57e-57
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005634	nucleus	GO:0030666	endocytic vesicle membrane	1.59e-05	7.63e-18
GO:0005634	nucleus	GO:0031966	mitochondrial membrane	7.12e-06	7.29e-05
GO:0005634	nucleus	GO:0045211	postsynaptic membrane	4.18e-05	1.09e-18
GO:0005634	nucleus	GO:0045334	clathrin-coated endocytic vesicle	6.29e-03	1.54e-23
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

Previous1 2Next

All Protein Interactions

Showing 1 to 10 of 59 entries

Search:

Interactor	Also a MoonDB EMF protein
AAPK2_HUMAN	No
ABL1_HUMAN	Yes: P00519 (MoonDB)
AMPH_HUMAN	No
ATX3_HUMAN	No
BAG3_HUMAN	No
CC90B_HUMAN	No
CNTRL_HUMAN	No
CRK_HUMAN	Yes: P46108 (MoonDB)
DC1I1_HUMAN	No
DCTN1_HUMAN	No

Previous1 2 3 4 5 6Next

Publications Associated

Showing 1 to 10 of 33 entries

Search:

PMID	Article Title
7590285	Isolation of an ubiquitously expressed cDNA encoding human dynamin II, a member of the large GTP-binding protein family.
11583995	Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton.
12498685	The large GTPase dynamin associates with the spindle midzone and is required for cytokinesis.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824	The DNA sequence and biology of human chromosome 19.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15703209	SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.
15731758	Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.
16227997	Mutations in dynamin 2 cause dominant centronuclear myopathy.
16234328	NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS.

Previous1 2 3 4Next

OMIM Diseases Associated

Showing 1 to 4 of 4 entries

Search:

OMIM ID	Disease Name
160150	Myopathy, centronuclear, 1
606482	Charcot-Marie-Tooth disease 2M
606482	Charcot-Marie-Tooth disease, dominant, intermediate type, B
615368	Lethal congenital contracture syndrome 5

Previous1Next

Protein Domains Associated

Showing 1 to 10 of 28 entries

Search:

Domain Name	Domain ID	Source
DLP_1	cd08771	CDD
DNM2	IPR027188	InterPro
DYNAMIN	PR00195	PRINTS
Dynamin_central	IPR000375	InterPro
Dynamin_GTPase	IPR001401	InterPro
Dynamin_GTPase_CS	IPR019762	InterPro
Dynamin_M	PF01031	Pfam
Dynamin_N	PF00350	Pfam
Dynamin_SF	IPR022812	InterPro
DYNc	SM00053	SMART

Previous1 2 3Next