UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P42858 (Uniprot)	HD_HUMAN	HTT	Huntingtin	human	No

Protein Function

Uniprot: May play a role in microtubule-mediated transport or vesicle function.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	222, 345	GO:0007165	signal transduction	486	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 79 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
17	GO:0006355	regulation of transcription, DNA-templated
51	GO:0060255	regulation of macromolecule metabolic process
120	GO:0006464	cellular protein modification process
120	GO:0070887	cellular response to chemical stimulus
120	GO:0031324	negative regulation of cellular metabolic process
120	GO:0010605	negative regulation of macromolecule metabolic process
120	GO:0051172	negative regulation of nitrogen compound metabolic process
120	GO:0031325	positive regulation of cellular metabolic process
120	GO:0010604	positive regulation of macromolecule metabolic process
120	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

Showing 1 to 10 of 44 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
17	GO:0005829	cytosol
17	GO:0005654	nucleoplasm
43	GO:0005634	nucleus
51	GO:0005634	nucleus
120	GO:0005829	cytosol
120	GO:0043232	intracellular non-membrane-bounded organelle
120	GO:0005654	nucleoplasm
214	GO:0044428	nuclear part
222	GO:0070013	intracellular organelle lumen
222	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 17 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000132	establishment of mitotic spindle orientation	IMP
GO:0006869	lipid transport	IEA
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	IMP
GO:0006915	apoptotic process	IEA
GO:0007030	Golgi organization	IMP
GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA
GO:0031648	protein destabilization	IMP
GO:0042297	vocal learning	IMP
GO:0043065	positive regulation of apoptotic process	IDA
GO:0043666	regulation of phosphoprotein phosphatase activity	IMP

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Cellular Components

Showing 1 to 10 of 15 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IMP
GO:0005654	nucleoplasm	IDA
GO:0005737	cytoplasm	IDA
GO:0005770	late endosome	IDA
GO:0005776	autophagosome	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005794	Golgi apparatus	IDA
GO:0005814	centriole	IDA
GO:0005829	cytosol	IDA
GO:0016234	inclusion body	IMP

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 8 of 8 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005770	late endosome	4.75e-02	1.57e-04
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0030659	cytoplasmic vesicle membrane	4.71e-30	7.28e-80
GO:0005654	nucleoplasm	GO:0005783	endoplasmic reticulum	1.84e-53	1.21e-118
GO:0005654	nucleoplasm	GO:0005794	Golgi apparatus	1.14e-11	3.23e-62
GO:0005654	nucleoplasm	GO:0030424	axon	9.82e-03	1.17e-43
GO:0005654	nucleoplasm	GO:0030659	cytoplasmic vesicle membrane	1.28e-24	2.03e-103

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All Protein Interactions

Showing 1 to 10 of 177 entries

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Interactor	Also a MoonDB EMF protein
1433B_HUMAN	No
ADDG_HUMAN	No
ANCHR_HUMAN	No
ANM2_HUMAN	No
AP2A2_HUMAN	No
APBB2_HUMAN	No
API5_HUMAN	No
ARFG3_HUMAN	No
BAIP2_HUMAN	No
BAZ1A_HUMAN	No

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Publications Associated

Showing 1 to 10 of 35 entries

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PMID	Article Title
7647777	Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form.
7759106	Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms.
7903579	Differential 3' polyadenylation of the Huntington disease gene results in two mRNA species with variable tissue expression.
8197474	Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat.
8458085	A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
8696339	Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract.
9700202	Huntingtin interacts with a family of WW domain proteins.
10332029	PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.
10958656	Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis.
11013077	Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat.

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OMIM Diseases Associated

Showing 1 to 2 of 2 entries

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OMIM ID	Disease Name
143100	Huntington disease
617435	Lopes-Maciel-Rodan syndrome

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Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
A46068	A46068	PIR
ARM-like	IPR011989	InterPro
ARM-type_fold	IPR016024	InterPro
DUF3652	PF12372	Pfam
Huntingtin	IPR000091	InterPro
HUNTINGTIN	PR00375	PRINTS
Huntingtin_fam	IPR028426	InterPro
Huntingtin_middle-repeat	IPR024613	InterPro
Lipovitellin_superhlx_dom	IPR011030	InterPro
PTHR10170	PTHR10170	PANTHER

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