Protein: O00291

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O00291 (Uniprot) HIP1_HUMAN HIP1 Huntingtin-interacting protein 1 human Yes
Uniprot: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). more..
Dissimilar Functions Manual Curation

Function 1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in a NMDA-dependent manner.

Function 2: Regulation of apoptosis, regulation of transcription. Condition: nuclear localization constitutive, enhanced upon androgen stimulation.

Publications (PMID): 16027218

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
297 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
134 GO:0005829 cytosol
134 GO:0005634 nucleus
297 GO:0005634 nucleus
447 GO:0005829 cytosol
447 GO:0043232 intracellular non-membrane-bounded organelle
447 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated IEA
GO:0006915 apoptotic process IDA
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
GO:0007010 cytoskeleton organization IEA
GO:0030100 regulation of endocytosis NAS
GO:0030154 cell differentiation IEA
GO:0042981 regulation of apoptotic process IDA
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IMP
GO:0048260 positive regulation of receptor-mediated endocytosis IMP
GO:0048268 clathrin coat assembly IDA
GO:0050821 protein stabilization IDA
GO:0051897 positive regulation of protein kinase B signaling IC
GO:0061024 membrane organization TAS
GO:0072583 clathrin-dependent endocytosis IEA
GO:0097190 apoptotic signaling pathway IDA
GO:0099637 neurotransmitter receptor transport TAS
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus TAS
GO:0005737 cytoplasm IDA
GO:0005794 Golgi apparatus IDA
GO:0005829 cytosol TAS
GO:0005856 cytoskeleton TAS
GO:0016020 membrane TAS
GO:0030122 AP-2 adaptor complex IDA
GO:0030136 clathrin-coated vesicle IDA
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0098793 presynapse IDA
GO:0098794 postsynapse TAS
GO:0098888 extrinsic component of presynaptic membrane IEA
GO:0098890 extrinsic component of postsynaptic membrane IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0030136 clathrin-coated vesicle 6.14e-04 7.94e-24
GO:0005634 nucleus GO:0098793 presynapse 3.45e-05 2.45e-27
GO:0005856 cytoskeleton GO:0043231 intracellular membrane-bounded organelle 3.21e-14 3.53e-300
PMID Article Title
9140394 HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.
9147654 HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system.
9616134 Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2).
11007801 Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain.
11063258 HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.
11517213 HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.
11532990 The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
11577110 Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins.
11788820 Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
11889126 HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
12163454 Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival.
12853948 The DNA sequence of human chromosome 7.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14732715 HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15533940 Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.
16027218 Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.
17257618 Crystal structure at 2.8 A of the DLLRKN-containing coiled-coil domain of huntingtin-interacting protein 1 (HIP1) reveals a surface suitable for clathrin light chain binding.
18155047 Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI).
18790740 Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
ILWEQ_dom IPR002558 InterPro
ENTH_VHS IPR008942 InterPro
ANTH_dom IPR011417 InterPro
ENTH IPR013809 InterPro
Sla2_fam IPR030224 InterPro
HIP1 IPR030554 InterPro
HIP1_clath-bd IPR032422 InterPro
I/LWEQ_dom_sf IPR035964 InterPro
ILWEQ PD011820 ProDom
I_LWEQ PF01608 Pfam
ANTH PF07651 Pfam
HIP1_clath_bdg PF16515 Pfam
ENTH PS50942 PROSITE
I_LWEQ PS50945 PROSITE
PTHR10407 PTHR10407 PANTHER
PTHR10407:SF14 PTHR10407:SF14 PANTHER
ENTH SM00273 SMART
ILWEQ SM00307 SMART
SSF109885 SSF109885 SUPFAM
SSF48464 SSF48464 SUPFAM