Protein: Q86X19 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q86X19 (Uniprot)	TMM17_HUMAN	TMEM17	Transmembrane protein 17	human	No

Protein Function

Uniprot: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0043170	macromolecule metabolic process	531	GO:0071705	nitrogen compound transport	624	9.47e-16	1.65e-67
GO:0043170	macromolecule metabolic process	531	GO:0042886	amide transport	663	2.11e-04	2.73e-69

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 36 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
10	GO:0007165	signal transduction
41	GO:0007165	signal transduction
128	GO:0007165	signal transduction
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
212	GO:0007165	signal transduction
217	GO:0060255	regulation of macromolecule metabolic process
217	GO:0007165	signal transduction
275	GO:0022607	cellular component assembly

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
30	GO:0005829	cytosol
30	GO:0043232	intracellular non-membrane-bounded organelle
41	GO:0030054	cell junction
41	GO:0044459	plasma membrane part
43	GO:0005634	nucleus
85	GO:0016021	integral component of membrane
128	GO:0012505	endomembrane system
128	GO:0016021	integral component of membrane
128	GO:0005886	plasma membrane
134	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007224	smoothened signaling pathway	ISS
GO:0060271	cilium assembly	ISS
GO:1905515	non-motile cilium assembly	IMP

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0016021	integral component of membrane	IEA
GO:0035869	ciliary transition zone	ISS
GO:0036038	MKS complex	ISS
GO:0060170	ciliary membrane	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 401 entries

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Interactor	Also a MoonDB EMF protein
1433F_HUMAN	No
1A03_HUMAN	No
4F2_HUMAN	No
AAAT_HUMAN	No
ABCE1_HUMAN	No
ACATN_HUMAN	No
ACSL3_HUMAN	No
ADCY9_HUMAN	No
ADDG_HUMAN	No
AGRL2_HUMAN	No

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Publications Associated

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PMID	Article Title
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
26982032	MKS5 and CEP290 dependent assembly pathway of the ciliary transition zone.

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OMIM Diseases Associated

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OMIM ID	Disease Name
277170	Orofaciodigital syndrome 6

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Protein Domains Associated

Showing 1 to 3 of 3 entries

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Domain Name	Domain ID	Source
PTHR13531	PTHR13531	PANTHER
Transmemb_17	PF09799	Pfam
Uncharacterised_TM-17	IPR019184	InterPro

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