Protein: Q14160

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q14160 (Uniprot) SCRIB_HUMAN SCRIB Protein scribble homolog human No
Uniprot: Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 255 GO:0006139 nucleobase-containing compound metabolic process 694 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 694 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
22 GO:0019538 protein metabolic process
22 GO:0007165 signal transduction
41 GO:0007165 signal transduction
139 GO:0023051 regulation of signaling
139 GO:0007165 signal transduction
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
240 GO:0019538 protein metabolic process
240 GO:0007165 signal transduction
242 GO:0022607 cellular component assembly
242 GO:0010605 negative regulation of macromolecule metabolic process
242 GO:0045934 negative regulation of nucleobase-containing compound metabolic process
242 GO:0009893 positive regulation of metabolic process
242 GO:2000112 regulation of cellular macromolecule biosynthetic process
242 GO:0010468 regulation of gene expression
242 GO:1903506 regulation of nucleic acid-templated transcription
242 GO:0007165 signal transduction
255 GO:0008283 cell proliferation
255 GO:0007166 cell surface receptor signaling pathway
255 GO:0006464 cellular protein modification process
255 GO:0060429 epithelium development
255 GO:0006139 nucleobase-containing compound metabolic process
255 GO:0006796 phosphate-containing compound metabolic process
255 GO:0006508 proteolysis
284 GO:0009966 regulation of signal transduction
343 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
391 GO:0034645 cellular macromolecule biosynthetic process
391 GO:0090304 nucleic acid metabolic process
391 GO:0034654 nucleobase-containing compound biosynthetic process
391 GO:0060255 regulation of macromolecule metabolic process
391 GO:0019219 regulation of nucleobase-containing compound metabolic process
432 GO:0007165 signal transduction
513 GO:0007165 signal transduction
530 GO:0016070 RNA metabolic process
530 GO:0060255 regulation of macromolecule metabolic process
694 GO:0090304 nucleic acid metabolic process
694 GO:0060255 regulation of macromolecule metabolic process
745 GO:0048468 cell development
745 GO:0007166 cell surface receptor signaling pathway
745 GO:0010467 gene expression
745 GO:0048699 generation of neurons
745 GO:0006139 nucleobase-containing compound metabolic process
745 GO:0060255 regulation of macromolecule metabolic process
806 GO:0007165 signal transduction
849 GO:0022607 cellular component assembly
849 GO:0006464 cellular protein modification process
849 GO:0006796 phosphate-containing compound metabolic process
849 GO:0010646 regulation of cell communication
849 GO:0023051 regulation of signaling
849 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
22 GO:0005576 extracellular region
22 GO:0005886 plasma membrane
22 GO:0031982 vesicle
41 GO:0030054 cell junction
41 GO:0044459 plasma membrane part
101 GO:0005829 cytosol
101 GO:0043232 intracellular non-membrane-bounded organelle
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
240 GO:0005615 extracellular space
242 GO:0043232 intracellular non-membrane-bounded organelle
242 GO:0070013 intracellular organelle lumen
242 GO:0005634 nucleus
255 GO:0012505 endomembrane system
255 GO:0016021 integral component of membrane
255 GO:0005886 plasma membrane
256 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0005634 nucleus
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
343 GO:0005634 nucleus
357 GO:0005654 nucleoplasm
391 GO:0070013 intracellular organelle lumen
391 GO:0005634 nucleus
432 GO:0005829 cytosol
432 GO:0005886 plasma membrane
502 GO:0005829 cytosol
502 GO:0031981 nuclear lumen
513 GO:0005829 cytosol
513 GO:0005634 nucleus
530 GO:0070013 intracellular organelle lumen
530 GO:0005634 nucleus
694 GO:0005634 nucleus
745 GO:0005634 nucleus
806 GO:0005634 nucleus
849 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001843 neural tube closure IMP
GO:0001921 positive regulation of receptor recycling IMP
GO:0007268 chemical synaptic transmission IBA
GO:0008283 cell proliferation IDA
GO:0016080 synaptic vesicle targeting IEA
GO:0016477 cell migration IMP
GO:0021747 cochlear nucleus development IEA
GO:0035089 establishment of apical/basal cell polarity IMP
GO:0039502 suppression by virus of host type I interferon-mediated signaling pathway IEA
GO:0039563 suppression by virus of host STAT1 activity IEA
GO:0039564 suppression by virus of host STAT2 activity IEA
GO:0042060 wound healing IEA
GO:0043065 positive regulation of apoptotic process IMP
GO:0043113 receptor clustering IBA
GO:0043615 astrocyte cell migration IEA
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
GO:0045930 negative regulation of mitotic cell cycle IDA
GO:0046037 GMP metabolic process IEA
GO:0046710 GDP metabolic process IEA
GO:0048488 synaptic vesicle endocytosis IEA
GO:0050918 positive chemotaxis IMP
GO:0060088 auditory receptor cell stereocilium organization IEA
GO:0060561 apoptotic process involved in morphogenesis IMP
GO:0060603 mammary gland duct morphogenesis ISS
GO:0071896 protein localization to adherens junction IMP
GO:0090630 activation of GTPase activity IMP
GO:0097120 receptor localization to synapse IBA
GO:0098609 cell-cell adhesion IGI
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA
GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm IDA
GO:0005886 plasma membrane IDA
GO:0005911 cell-cell junction IDA
GO:0005913 cell-cell adherens junction IDA
GO:0008328 ionotropic glutamate receptor complex IBA
GO:0014069 postsynaptic density IBA
GO:0016323 basolateral plasma membrane IBA
GO:0030027 lamellipodium IEA
GO:0030054 cell junction IDA
GO:0031252 cell leading edge IDA
GO:0034750 Scrib-APC-beta-catenin complex IDA
GO:0035748 myelin sheath abaxonal region IEA
GO:0042734 presynaptic membrane IDA
GO:0044291 cell-cell contact zone IEA
GO:0045211 postsynaptic membrane IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0005911 cell-cell junction 3.44e-02 2.10e-14
GO:0005654 nucleoplasm GO:0016323 basolateral plasma membrane 7.74e-03 2.03e-05
GO:0005654 nucleoplasm GO:0030054 cell junction 3.08e-04 1.38e-34
GO:0005654 nucleoplasm GO:0045211 postsynaptic membrane 4.67e-04 3.99e-53
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
PMID Article Title
8590280 Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
11027293 Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase.
12168954 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15182672 Mammalian Scribble forms a tight complex with the betaPIX exchange factor.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15649318 The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus.
15775968 Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway.
15806148 Junctional recruitment of mammalian Scribble relies on E-cadherin engagement.
15975580 hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells.
16137684 The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins.
16344308 The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin.
16421571 DNA sequence and analysis of human chromosome 8.
16611247 Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.
16965391 Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18042258 Tick-borne encephalitis virus NS5 associates with membrane protein scribble and impairs interferon-stimulated JAK-STAT signalling.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18641685 Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.
18669648 A quantitative atlas of mitotic phosphorylation.
18716323 Scrib regulates PAK activity during the cell migration process.
19041750 Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.
19369195 Large-scale proteomics analysis of the human kinome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19555689 MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22095531 Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.
22480440 The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
28169360 Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway.
OMIM ID Disease Name
182940 Neural tube defects
Domain Name Domain ID Source
PDZ IPR001478 InterPro
Leu-rich_rpt IPR001611 InterPro
Leu-rich_rpt_typical-subtyp IPR003591 InterPro
LRR_dom_sf IPR032675 InterPro
PDZ_sf IPR036034 InterPro
PDZ PF00595 Pfam
LRR_8 PF13855 Pfam
PDZ PS50106 PROSITE
LRR PS51450 PROSITE
PDZ SM00228 SMART
LRR_TYP SM00369 SMART
SSF50156 SSF50156 SUPFAM
SSF52058 SSF52058 SUPFAM