Protein: Q96Q45

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q96Q45 (Uniprot) TM237_HUMAN TMEM237 Transmembrane protein 237 human No
Uniprot: Component of the transition zone in primary cilia. Required for ciliogenesis.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 22 GO:0022610 biological adhesion 869 2.68e-16 4.92e-03
GO:0034641 cellular nitrogen compound metabolic process 789 GO:0007165 signal transduction 803 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 789 GO:0022610 biological adhesion 869 6.87e-63 4.34e-65
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
22 GO:0019538 protein metabolic process
22 GO:0007165 signal transduction
128 GO:0007165 signal transduction
358 GO:0006464 cellular protein modification process
358 GO:0060255 regulation of macromolecule metabolic process
358 GO:0007165 signal transduction
716 GO:0010646 regulation of cell communication
716 GO:0023051 regulation of signaling
716 GO:0007165 signal transduction
789 GO:0044271 cellular nitrogen compound biosynthetic process
789 GO:0044267 cellular protein metabolic process
789 GO:0071310 cellular response to organic substance
789 GO:0031325 positive regulation of cellular metabolic process
789 GO:0010604 positive regulation of macromolecule metabolic process
789 GO:0051173 positive regulation of nitrogen compound metabolic process
789 GO:2000112 regulation of cellular macromolecule biosynthetic process
789 GO:0010468 regulation of gene expression
789 GO:0007165 signal transduction
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
14 GO:0031410 cytoplasmic vesicle
14 GO:0005829 cytosol
14 GO:0005783 endoplasmic reticulum
22 GO:0005576 extracellular region
22 GO:0005886 plasma membrane
22 GO:0031982 vesicle
65 GO:0012505 endomembrane system
65 GO:0016021 integral component of membrane
85 GO:0016021 integral component of membrane
128 GO:0012505 endomembrane system
128 GO:0016021 integral component of membrane
128 GO:0005886 plasma membrane
168 GO:0012505 endomembrane system
168 GO:0016021 integral component of membrane
174 GO:0016021 integral component of membrane
179 GO:0012505 endomembrane system
200 GO:0070013 intracellular organelle lumen
349 GO:0016021 integral component of membrane
358 GO:0012505 endomembrane system
358 GO:0005615 extracellular space
358 GO:0005886 plasma membrane
358 GO:0031982 vesicle
366 GO:0005783 endoplasmic reticulum
366 GO:0016021 integral component of membrane
396 GO:0012505 endomembrane system
666 GO:0016021 integral component of membrane
716 GO:0016021 integral component of membrane
716 GO:0005886 plasma membrane
789 GO:0005654 nucleoplasm
799 GO:0012505 endomembrane system
799 GO:0016021 integral component of membrane
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0030111 regulation of Wnt signaling pathway IMP
GO:0060271 cilium assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0016020 membrane IDA
GO:0016021 integral component of membrane IEA
GO:0035869 ciliary transition zone IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
S41A1_HUMAN No
Q8TBU1_HUMAN No
A0A1B0GTW0_HUMAN No
A5D903_HUMAN No
A5PKU2_HUMAN No
ABHGA_HUMAN No
ADIPO_HUMAN No
AL3A2_HUMAN No
APOD_HUMAN No
APOL3_HUMAN No
AT131_HUMAN No
BAP31_HUMAN No
BET1_HUMAN No
BLCAP_HUMAN No
BNIP2_HUMAN No
BT2A2_HUMAN No
CC167_HUMAN No
CCD47_HUMAN No
CD003_HUMAN No
CD53_HUMAN No
CDKAL_HUMAN No
CDS1_HUMAN No
CKAP4_HUMAN No
CLD4_HUMAN No
CNIH3_HUMAN No
COPA_HUMAN No
COPB2_HUMAN No
CTR1_HUMAN No
CTR3_HUMAN No
CXB2_HUMAN No
CXCL9_HUMAN No
CYB5B_HUMAN No
ECH1_HUMAN No
EFNA5_HUMAN No
EMC1_HUMAN No
EMC2_HUMAN No
EMC3_HUMAN No
EMC6_HUMAN No
EMC8_HUMAN No
EMD_HUMAN No
ERMP1_HUMAN No
EXTL1_HUMAN No
FHR5_HUMAN No
FKB14_HUMAN No
FXYD6_HUMAN No
FZD7_HUMAN No
GKN2_HUMAN No
GLPA_HUMAN No
GRM2_HUMAN No
GTR5_HUMAN No
GUC2A_HUMAN No
IBP5_HUMAN No
IF_HUMAN No
INSI1_HUMAN No
INSI2_HUMAN No
IR3IP_HUMAN No
JAGN1_HUMAN No
KTN1_HUMAN No
LERL1_HUMAN No
LIPR1_HUMAN No
LPAR3_HUMAN No
LRC59_HUMAN No
LRP10_HUMAN No
LYRIC_HUMAN No
M4A13_HUMAN No
MACOI_HUMAN No
MFF_HUMAN No
MFSD5_HUMAN No
MFSD6_HUMAN No
MMGT1_HUMAN No
MOT5_HUMAN No
MTPN_HUMAN No
NPHP1_HUMAN No
OPRD_HUMAN No
ORML3_HUMAN No
OTOP2_HUMAN No
OTOP3_HUMAN No
PAI1_HUMAN No
PLPR2_HUMAN No
PRIO_HUMAN Yes: P04156 (MoonDB)
Q08AM2_HUMAN No
Q59EV6_HUMAN No
Q96FB2_HUMAN No
RAE1L_HUMAN No
ROBO2_HUMAN No
RPRM_HUMAN No
S12A7_HUMAN No
S35A4_HUMAN No
S35B2_HUMAN No
S35B4_HUMAN No
S35E4_HUMAN No
S35G1_HUMAN No
S38A2_HUMAN No
S38A7_HUMAN No
S39A2_HUMAN No
S39A9_HUMAN No
S52A1_HUMAN No
SC22A_HUMAN No
SC5A4_HUMAN No
SERP2_HUMAN No
SRP09_HUMAN No
SRP72_HUMAN No
SRPRA_HUMAN No
STX8_HUMAN No
T179B_HUMAN No
T4S19_HUMAN No
TEFF2_HUMAN No
TM107_HUMAN No
TM128_HUMAN No
TM144_HUMAN No
TM147_HUMAN No
TM254_HUMAN No
TM6S2_HUMAN No
TM86B_HUMAN No
TMM11_HUMAN No
TMM17_HUMAN Yes: Q86X19 (MoonDB)
TMM42_HUMAN No
TMM60_HUMAN No
TNFB_HUMAN No
TOIP1_HUMAN No
TTMP_HUMAN No
UN93A_HUMAN No
UN93B_HUMAN No
UPK1B_HUMAN No
VAMP3_HUMAN No
VEGFA_HUMAN Yes: P15692 (MoonDB)
WDR81_HUMAN No
YIPF6_HUMAN No
ZFPL1_HUMAN No
ZNT8_HUMAN No
PMID Article Title
11586298 A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17974005 The full-ORF clone resource of the German cDNA consortium.
22152675 TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
26595381 TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
OMIM ID Disease Name
614424 Joubert syndrome 14
Domain Name Domain ID Source
TMEM237 IPR029409 InterPro
TMEM237 PF15383 Pfam
PTHR28388 PTHR28388 PANTHER