Protein: Q16659

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q16659 (Uniprot) MK06_HUMAN MAPK6 Mitogen-activated protein kinase 6 human No
Uniprot: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 512 GO:0034641 cellular nitrogen compound metabolic process 595, 789 4.22e-144 6.90e-18
GO:0007165 signal transduction 512 GO:0006725 cellular aromatic compound metabolic process 614 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
6 GO:0034645 cellular macromolecule biosynthetic process
6 GO:0010467 gene expression
6 GO:0090304 nucleic acid metabolic process
6 GO:0060255 regulation of macromolecule metabolic process
195 GO:0006468 protein phosphorylation
195 GO:0010468 regulation of gene expression
195 GO:0051246 regulation of protein metabolic process
195 GO:0007165 signal transduction
261 GO:0006355 regulation of transcription, DNA-templated
297 GO:0007165 signal transduction
431 GO:0019538 protein metabolic process
431 GO:0060255 regulation of macromolecule metabolic process
512 GO:0035556 intracellular signal transduction
512 GO:0006468 protein phosphorylation
512 GO:0060255 regulation of macromolecule metabolic process
547 GO:0060255 regulation of macromolecule metabolic process
594 GO:0044267 cellular protein metabolic process
594 GO:0010467 gene expression
594 GO:0060255 regulation of macromolecule metabolic process
595 GO:0044271 cellular nitrogen compound biosynthetic process
595 GO:0006464 cellular protein modification process
595 GO:0035556 intracellular signal transduction
595 GO:0006139 nucleobase-containing compound metabolic process
595 GO:0031325 positive regulation of cellular metabolic process
595 GO:0010604 positive regulation of macromolecule metabolic process
595 GO:0051173 positive regulation of nitrogen compound metabolic process
595 GO:0031326 regulation of cellular biosynthetic process
595 GO:0010468 regulation of gene expression
614 GO:0006139 nucleobase-containing compound metabolic process
654 GO:0010467 gene expression
654 GO:0019538 protein metabolic process
654 GO:0060255 regulation of macromolecule metabolic process
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
785 GO:0016070 RNA metabolic process
785 GO:0006464 cellular protein modification process
785 GO:0010467 gene expression
785 GO:0060255 regulation of macromolecule metabolic process
787 GO:0016070 RNA metabolic process
787 GO:0010467 gene expression
787 GO:0060255 regulation of macromolecule metabolic process
787 GO:0007165 signal transduction
789 GO:0044271 cellular nitrogen compound biosynthetic process
789 GO:0044267 cellular protein metabolic process
789 GO:0071310 cellular response to organic substance
789 GO:0031325 positive regulation of cellular metabolic process
789 GO:0010604 positive regulation of macromolecule metabolic process
789 GO:0051173 positive regulation of nitrogen compound metabolic process
789 GO:2000112 regulation of cellular macromolecule biosynthetic process
789 GO:0010468 regulation of gene expression
789 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
6 GO:0043232 intracellular non-membrane-bounded organelle
6 GO:0005654 nucleoplasm
168 GO:0012505 endomembrane system
168 GO:0016021 integral component of membrane
195 GO:0005829 cytosol
195 GO:0005634 nucleus
261 GO:0031981 nuclear lumen
297 GO:0005634 nucleus
370 GO:0005829 cytosol
370 GO:0043232 intracellular non-membrane-bounded organelle
370 GO:0005634 nucleus
431 GO:0005829 cytosol
447 GO:0005829 cytosol
447 GO:0043232 intracellular non-membrane-bounded organelle
447 GO:0005634 nucleus
512 GO:0005829 cytosol
547 GO:0005654 nucleoplasm
594 GO:0070013 intracellular organelle lumen
594 GO:0005634 nucleus
595 GO:0005654 nucleoplasm
614 GO:0005829 cytosol
614 GO:0005634 nucleus
654 GO:0005654 nucleoplasm
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
785 GO:0005634 nucleus
787 GO:0005634 nucleus
789 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade IEA
GO:0006468 protein phosphorylation ISS
GO:0007049 cell cycle IEA
GO:0007165 signal transduction TAS
GO:0010468 regulation of gene expression IBA
GO:0060999 positive regulation of dendritic spine development IEA
GO:0071310 cellular response to organic substance IBA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IBA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IBA
GO:0005829 cytosol TAS
GO:0032156 septin cytoskeleton IEA
GO:0043234 protein complex IEA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
APBA2_HUMAN No
GLRX3_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
ATG9A_HUMAN No
EGLN3_HUMAN No
ARPC3_HUMAN No
PLK1_HUMAN Yes: P53350 (MoonDB)
PLS1_HUMAN No
WFS1_HUMAN No
S41A3_HUMAN No
ZN205_HUMAN No
BAG6_HUMAN No
CNTRL_HUMAN No
2AAA_HUMAN No
INS_HUMAN No
CH60_HUMAN No
PTPM1_HUMAN No
NECT2_HUMAN No
ZN775_HUMAN No
SPG7_HUMAN No
MCM3_HUMAN No
CENPR_HUMAN No
SEPT5_HUMAN No
RACK1_HUMAN No
SEPT3_HUMAN No
SOCS3_HUMAN No
GORS1_HUMAN No
PDLI1_HUMAN No
AAKB1_HUMAN No
ACTG_HUMAN No
ACTY_HUMAN No
AMPH_HUMAN No
ANK3_HUMAN No
ANKR2_HUMAN No
APC5_HUMAN No
APOA1_HUMAN No
ATP5J_HUMAN No
BARX1_HUMAN No
BBS10_HUMAN No
CAD13_HUMAN No
CAH12_HUMAN No
CAH1_HUMAN No
CALR_HUMAN No
CASP6_HUMAN No
CCND3_HUMAN No
CERS1_HUMAN No
CNTN1_HUMAN No
COF1_HUMAN No
CREL2_HUMAN No
CSN6_HUMAN No
CU059_HUMAN No
CXCL7_HUMAN No
CYH2_HUMAN No
DCTN2_HUMAN No
DDR1_HUMAN No
DGKZ_HUMAN No
DJC28_HUMAN No
DKC1_HUMAN No
DPPA4_HUMAN No
DREB_HUMAN No
DSCR3_HUMAN No
DYST_HUMAN No
EDF1_HUMAN No
EF1A2_HUMAN No
EF1D_HUMAN No
EIF1_HUMAN No
EIF3C_HUMAN No
ELOF1_HUMAN No
EMD_HUMAN No
ENPL_HUMAN No
FA49B_HUMAN No
FOXO3_HUMAN No
FXL16_HUMAN No
FXYD3_HUMAN No
GALT7_HUMAN No
GATA1_HUMAN No
GDIR1_HUMAN No
GPX1_HUMAN No
HACL1_HUMAN No
HAUS2_HUMAN No
HDA11_HUMAN No
HIP1_HUMAN Yes: O00291 (MoonDB)
HNRH3_HUMAN No
HNRPD_HUMAN Yes: Q14103 (MoonDB)
IDH3B_HUMAN No
IF4A1_HUMAN No
ITSN1_HUMAN No
JUNB_HUMAN No
KAIN_HUMAN No
KAP0_HUMAN No
KDSR_HUMAN No
KIBRA_HUMAN No
KLC1_HUMAN No
LPXN_HUMAN No
M3K12_HUMAN No
M3K7_HUMAN Yes: O43318 (MoonDB)
MAPK5_HUMAN No
MASP1_HUMAN No
MBIP1_HUMAN No
MBOA7_HUMAN No
MET17_HUMAN No
MET2A_HUMAN No
MGAT1_HUMAN No
MIPEP_HUMAN No
MK_HUMAN No
MOK_HUMAN No
MON1A_HUMAN No
MTG2_HUMAN No
MYBB_HUMAN No
MYOZ3_HUMAN No
MZB1_HUMAN No
NAT9_HUMAN No
NDUS6_HUMAN No
NELFB_HUMAN No
NNRE_HUMAN No
NOL4_HUMAN No
NPA1P_HUMAN No
NRX2A_HUMAN No
NRX2B_HUMAN No
NUDT5_HUMAN No
OST48_HUMAN No
OSTF1_HUMAN No
PDC6I_HUMAN Yes: Q8WUM4 (MoonDB)
PHAR3_HUMAN No
PHC2_HUMAN Yes: Q8IXK0 (MoonDB)
PIHD1_HUMAN No
PKHM1_HUMAN No
PP1R7_HUMAN No
PR38A_HUMAN No
PSIP1_HUMAN No
RAB2A_HUMAN No
RAB31_HUMAN No
RANB9_HUMAN No
RARA_HUMAN Yes: P10276 (MoonDB)
RBL1_HUMAN No
RGS19_HUMAN No
RL10_HUMAN No
RL40_HUMAN No
ROA0_HUMAN No
RPGP1_HUMAN No
RRP7A_HUMAN No
S20A1_HUMAN No
SERA_HUMAN No
SERC_HUMAN No
SHC1_HUMAN No
SKAP_HUMAN No
SMAD6_HUMAN No
SNPC4_HUMAN No
SNW1_HUMAN No
SPR2D_HUMAN No
SPSY_HUMAN No
SPTN1_HUMAN No
SRSF5_HUMAN No
STX7_HUMAN No
SUSD4_HUMAN No
TBA1A_HUMAN No
TCPG_HUMAN No
THAP4_HUMAN No
TPIS_HUMAN No
TTK_HUMAN No
TYDP2_HUMAN No
UB2L3_HUMAN Yes: P68036 (MoonDB)
WDR26_HUMAN No
WDR34_HUMAN No
XPO2_HUMAN No
ZN133_HUMAN No
ZN331_HUMAN No
ZN579_HUMAN No
ZN600_HUMAN No
ZN671_HUMAN No
PMID Article Title
7969157 Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.
8875998 Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15226418 N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17344846 Patterns of somatic mutation in human cancer genomes.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19054851 Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19369195 Large-scale proteomics analysis of the human kinome.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21177870 Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway.
22645313 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
A56352 A56352 PIR
Prot_kinase_dom IPR000719 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
MAPK_ERK3/4 IPR008350 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Pkinase PF00069 Pfam
ERK3ERK4MAPK PR01771 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
S_TKc SM00220 SMART
SSF56112 SSF56112 SUPFAM