Protein: Q8IXK0

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8IXK0 (Uniprot) PHC2_HUMAN PHC2 Polyhomeotic-like protein 2 human No
Uniprot: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 682 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
84 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
567 GO:0005634 nucleus
682 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007275 multicellular organism development IEA
GO:0007283 spermatogenesis IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000792 heterochromatin IEA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0031519 PcG protein complex IDA
GO:0035102 PRC1 complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9121482 Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.
9199346 RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.
10976766 A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.
12167701 The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
12384788 Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15094067 P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity.
15386022 Role of histone H2A ubiquitination in Polycomb silencing.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16710414 The DNA sequence and biological annotation of human chromosome 1.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
18669648 A quantitative atlas of mitotic phosphorylation.
19636380 Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21282530 Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
SAM IPR001660 InterPro
Znf_FCS IPR012313 InterPro
SAM/pointed_sf IPR013761 InterPro
SAM_1 PF00536 Pfam
SAM_DOMAIN PS50105 PROSITE
ZF_FCS PS51024 PROSITE
SAM SM00454 SMART
SSF47769 SSF47769 SUPFAM