Protein: Q14103

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q14103 (Uniprot) HNRPD_HUMAN HNRNPD Heterogeneous nuclear ribonucleoprotein D0 human No
Uniprot: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 56, 379, 643 GO:0016070 RNA metabolic process 715 5.15e-08 2.82e-13
GO:0019538 protein metabolic process 56, 379, 643 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
56 GO:0044267 cellular protein metabolic process
56 GO:0060255 regulation of macromolecule metabolic process
81 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
379 GO:0044267 cellular protein metabolic process
379 GO:0009059 macromolecule biosynthetic process
379 GO:0051246 regulation of protein metabolic process
464 GO:0016070 RNA metabolic process
464 GO:0010467 gene expression
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
643 GO:0044267 cellular protein metabolic process
654 GO:0010467 gene expression
654 GO:0019538 protein metabolic process
654 GO:0060255 regulation of macromolecule metabolic process
715 GO:0006396 RNA processing
715 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
56 GO:0005829 cytosol
60 GO:0005634 nucleus
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
379 GO:0005829 cytosol
379 GO:0005576 extracellular region
379 GO:0005634 nucleus
464 GO:0070013 intracellular organelle lumen
464 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
643 GO:0005634 nucleus
654 GO:0005654 nucleoplasm
715 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0001889 liver development IEA
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0006396 RNA processing TAS
GO:0006401 RNA catabolic process TAS
GO:0016070 RNA metabolic process TAS
GO:0021549 cerebellum development IEA
GO:0032204 regulation of telomere maintenance ISS
GO:0042493 response to drug IEA
GO:0042752 regulation of circadian rhythm IMP
GO:0043488 regulation of mRNA stability TAS
GO:0045727 positive regulation of translation IMP
GO:0045893 positive regulation of transcription, DNA-templated NAS
GO:0048255 mRNA stabilization IEA
GO:0051592 response to calcium ion IEA
GO:0051602 response to electrical stimulus IEA
GO:0061158 3'-UTR-mediated mRNA destabilization IEA
GO:0071230 cellular response to amino acid stimulus IEA
GO:0071392 cellular response to estradiol stimulus IEA
GO:0071732 cellular response to nitric oxide IEA
GO:0097167 circadian regulation of translation IMP
GO:1901355 response to rapamycin IEA
GO:1904355 positive regulation of telomere capping ISS
GO:1904383 response to sodium phosphate IEA
GO:1904586 cellular response to putrescine IEA
GO:1905663 positive regulation of telomerase RNA reverse transcriptase activity ISS
GO:1990828 hepatocyte dedifferentiation IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus NAS
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
GO:0030529 intracellular ribonucleoprotein complex IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
PMID Article Title
1433497 Identification and cloning of a novel heterogeneous nuclear ribonucleoprotein C-like protein that functions as a transcriptional activator of the hepatitis B virus enhancer II.
3754960 A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2.
7673195 The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family.
8321232 Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n.
9521873 Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms.
9615222 The human HNRPD locus maps to 4q21 and encodes a highly conserved protein.
10024518 Heterogeneous nuclear ribonucleoprotein D0B is a sequence-specific DNA-binding protein.
10080887 Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0.
11051545 A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.
12674497 Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15782174 Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17289661 Molecular composition of IMP1 ribonucleoprotein granules.
18318008 Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19369195 Large-scale proteomics analysis of the human kinome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21515746 Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24423872 AUF1 contributes to Cryptochrome1 mRNA degradation and rhythmic translation.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25944712 N-terminome analysis of the human mitochondrial proteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
A24016 A24016 PIR
A44192 A44192 PIR
B48138 B48138 PIR
RRM_dom IPR000504 InterPro
CARG-binding_factor_N IPR012956 InterPro
RBD_domain_sf IPR035979 InterPro
RRM_1 PF00076 Pfam
CBFNT PF08143 Pfam
RRM PS50102 PROSITE
RRM SM00360 SMART
SSF54928 SSF54928 SUPFAM