Protein: Q00610 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q00610 (Uniprot)	CLH1_HUMAN	CLTC	Clathrin heavy chain 1	human	Yes

Protein Function

Uniprot: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetoc more..

Dissimilar Functions Manual Curation

Function 1: Membrane trafficking, endocytosis. Condition: presence in a trimeric form.

Function 2: Involved in mitosis. Also, P53-mediated transcription regulation. Condition: monomeric form for the transcription role. Interaction with microtubules, located at the mitotic spindle for the mitotic role.

Publications (PMID): 15858577, 17952123, 19766654, 19509056, 16618797

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

Showing 1 to 6 of 6 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
190	GO:0005829	cytosol
190	GO:0043232	intracellular non-membrane-bounded organelle
317	GO:0005829	cytosol
447	GO:0005829	cytosol
447	GO:0043232	intracellular non-membrane-bounded organelle
447	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 21 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000278	mitotic cell cycle	IMP
GO:0001649	osteoblast differentiation	IDA
GO:0006886	intracellular protein transport	NAS
GO:0006898	receptor-mediated endocytosis	IMP
GO:0006914	autophagy	IEA
GO:0007018	microtubule-based movement	TAS
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
GO:0031623	receptor internalization	IMP
GO:0032802	low-density lipoprotein particle receptor catabolic process	TAS
GO:0033572	transferrin transport	IMP

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Cellular Components

Showing 1 to 10 of 22 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005764	lysosome	IDA
GO:0005768	endosome	IDA
GO:0005819	spindle	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0005925	focal adhesion	IDA
GO:0016020	membrane	IDA
GO:0030118	clathrin coat	NAS
GO:0030130	clathrin coat of trans-Golgi network vesicle	IEA
GO:0030132	clathrin coat of coated pit	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 2 of 2 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005819	spindle	GO:0005886	plasma membrane	2.71e-05	1.10e-14
GO:0005829	cytosol	GO:0031012	extracellular matrix	4.46e-06	5.18e-08

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All Protein Interactions

Showing 1 to 10 of 36 entries

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Interactor	Also a MoonDB EMF protein
ACOC_HUMAN	Yes: P21399 (MoonDB)
AP1G1_HUMAN	No
AP2A2_HUMAN	No
AP2B1_HUMAN	No
ARMX3_HUMAN	No
ARRB1_HUMAN	Yes: P49407 (MoonDB)
CEP97_HUMAN	No
CJ088_HUMAN	No
CNTRL_HUMAN	No
DCTN1_HUMAN	No

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Publications Associated

Showing 1 to 10 of 32 entries

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PMID	Article Title
1765375	Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter.
7584026	Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
11532990	The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
12665801	Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15858577	Clathrin is required for the function of the mitotic spindle.
16314522	Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
16968737	Trimerisation is important for the function of clathrin at the mitotic spindle.
17081065	Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
17974005	The full-ORF clone resource of the German cDNA consortium.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 16 entries

Search:

Domain Name	Domain ID	Source
A40573	A40573	PIR
ARM-type_fold	IPR016024	InterPro
CHCR	PS50236	PROSITE
Clathrin	PF00637	Pfam
Clathrin-link	PF09268	Pfam
Clathrin_H-chain/VPS_repeat	IPR000547	InterPro
Clathrin_H-chain_linker_core	IPR015348	InterPro
Clathrin_H-chain_N	IPR016025	InterPro
Clathrin_H-chain_propeller_rpt	IPR022365	InterPro
Clathrin_H_chain	PIRSF002290	PIRSF

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