Protein: Q00610

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q00610 (Uniprot) CLH1_HUMAN CLTC Clathrin heavy chain 1 human Yes
Uniprot: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). more..
Dissimilar Functions Manual Curation

Function 1: Membrane trafficking, endocytosis. Condition: presence in a trimeric form.

Function 2: Involved in mitosis. Also, P53-mediated transcription regulation. Condition: monomeric form for the transcription role. Interaction with microtubules, located at the mitotic spindle for the mitotic role.

Publications (PMID): 15858577, 17952123, 19766654, 19509056, 16618797

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
317 GO:0005829 cytosol
447 GO:0005829 cytosol
447 GO:0043232 intracellular non-membrane-bounded organelle
447 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000278 mitotic cell cycle IMP
GO:0001649 osteoblast differentiation IDA
GO:0006886 intracellular protein transport NAS
GO:0006898 receptor-mediated endocytosis IMP
GO:0006914 autophagy IEA
GO:0007018 microtubule-based movement TAS
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
GO:0031623 receptor internalization IMP
GO:0032802 low-density lipoprotein particle receptor catabolic process TAS
GO:0033572 transferrin transport IMP
GO:0034383 low-density lipoprotein particle clearance TAS
GO:0042147 retrograde transport, endosome to Golgi IMP
GO:0045056 transcytosis IMP
GO:0048268 clathrin coat assembly IMP
GO:0051301 cell division IEA
GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
GO:0060236 regulation of mitotic spindle organization IMP
GO:0061024 membrane organization TAS
GO:0072583 clathrin-dependent endocytosis IMP
GO:1900126 negative regulation of hyaluronan biosynthetic process IDA
GO:1903077 negative regulation of protein localization to plasma membrane IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005764 lysosome IDA
GO:0005768 endosome IDA
GO:0005819 spindle IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005925 focal adhesion IDA
GO:0016020 membrane IDA
GO:0030118 clathrin coat NAS
GO:0030130 clathrin coat of trans-Golgi network vesicle IEA
GO:0030132 clathrin coat of coated pit IEA
GO:0030136 clathrin-coated vesicle IDA
GO:0030669 clathrin-coated endocytic vesicle membrane TAS
GO:0031012 extracellular matrix IDA
GO:0032588 trans-Golgi network membrane TAS
GO:0036020 endolysosome membrane TAS
GO:0042470 melanosome IEA
GO:0043234 protein complex IDA
GO:0045334 clathrin-coated endocytic vesicle NAS
GO:0070062 extracellular exosome IDA
GO:0071439 clathrin complex IDA
GO:1903561 extracellular vesicle IDA
GO:1990498 mitotic spindle microtubule IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005819 spindle GO:0005886 plasma membrane 2.71e-05 1.10e-14
GO:0005829 cytosol GO:0031012 extracellular matrix 4.46e-06 5.18e-08
PMID Article Title
1765375 Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter.
7584026 Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.
11532990 The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15858577 Clathrin is required for the function of the mitotic spindle.
16314522 Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.
16968737 Trimerisation is important for the function of clathrin at the mitotic spindle.
17081065 Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
17974005 The full-ORF clone resource of the German cDNA consortium.
18529014 FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19369195 Large-scale proteomics analysis of the human kinome.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20639872 Plasma membrane contributes to the formation of pre-autophagosomal structures.
21266579 Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
21269460 Initial characterization of the human central proteome.
21297582 A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.
21816279 Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23532825 Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.
23918938 Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25596274 TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation.
25944712 N-terminome analysis of the human mitochondrial proteome.
26756164 USP2-45 is a circadian clock output effector regulating calcium absorption at the post-translational level.
27022195 Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.
No results found.
Domain Name Domain ID Source
A40573 A40573 PIR
Clathrin_H-chain/VPS_repeat IPR000547 InterPro
TPR-like_helical_dom_sf IPR011990 InterPro
Clathrin_H-chain_linker_core IPR015348 InterPro
ARM-type_fold IPR016024 InterPro
Clathrin_H-chain_N IPR016025 InterPro
Clathrin_heavy_chain IPR016341 InterPro
Clathrin_H-chain_propeller_rpt IPR022365 InterPro
Clathrin PF00637 Pfam
Clathrin_propel PF01394 Pfam
Clathrin-link PF09268 Pfam
Clathrin_H_chain PIRSF002290 PIRSF
CHCR PS50236 PROSITE
CLH SM00299 SMART
SSF48371 SSF48371 SUPFAM
SSF50989 SSF50989 SUPFAM