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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P36873
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P36873 (Uniprot)
PP1G_HUMAN
PPP1CC
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
human
No
Protein Function
Uniprot:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein sy
nthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
more..
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0007165
signal transduction
169
,
534
GO:0006725
cellular aromatic compound metabolic process
345
,
585
5.44e-126
5.27e-27
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 151 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
2
GO:0044267
cellular protein metabolic process
2
GO:0010467
gene expression
2
GO:0006139
nucleobase-containing compound metabolic process
2
GO:0060255
regulation of macromolecule metabolic process
2
GO:0007165
signal transduction
25
GO:0006464
cellular protein modification process
25
GO:0010467
gene expression
25
GO:0060255
regulation of macromolecule metabolic process
25
GO:0007165
signal transduction
26
GO:0006464
cellular protein modification process
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Cellular Components
Showing 1 to 10 of 77 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
2
GO:0005829
cytosol
2
GO:0005634
nucleus
25
GO:0005829
cytosol
25
GO:0005634
nucleus
26
GO:0005654
nucleoplasm
51
GO:0005634
nucleus
105
GO:0005634
nucleus
106
GO:0005829
cytosol
106
GO:0005654
nucleoplasm
107
GO:0005829
cytosol
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Protein GO Annotations
Biological Processes
Showing 1 to 9 of 9 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0005977
glycogen metabolic process
IEA
GO:0006470
protein dephosphorylation
IMP
GO:0007062
sister chromatid cohesion
TAS
GO:0030182
neuron differentiation
IEA
GO:0032922
circadian regulation of gene expression
ISS
GO:0042752
regulation of circadian rhythm
IMP
GO:0043153
entrainment of circadian clock by photoperiod
ISS
GO:0046822
regulation of nucleocytoplasmic transport
IEA
GO:0051301
cell division
IEA
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Cellular Components
Showing 1 to 10 of 15 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000777
condensed chromosome kinetochore
IEA
GO:0000784
nuclear chromosome, telomeric region
IDA
GO:0005634
nucleus
IDA
GO:0005730
nucleolus
IDA
GO:0005737
cytoplasm
IDA
GO:0005739
mitochondrion
IDA
GO:0005741
mitochondrial outer membrane
IEA
GO:0005829
cytosol
TAS
GO:0005925
focal adhesion
IDA
GO:0016607
nuclear speck
IEA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 164 entries
Search:
Interactor
Also a MoonDB EMF protein
A1DRY3_HUMAN
No
ABT1_HUMAN
No
ACAD8_HUMAN
No
ANR42_HUMAN
No
ARF_HUMAN
No
ASH2L_HUMAN
No
ASPP1_HUMAN
No
ASPP2_HUMAN
No
ATD3A_HUMAN
No
ATM_HUMAN
No
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Publications Associated
Showing 1 to 10 of 30 entries
Search:
PMID
Article Title
7500362
Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.
7556599
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.
8111128
Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.
8394140
Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.
9414128
PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1.
11535607
Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
11564868
Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
11739654
Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
12226088
Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
12529430
Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 12 entries
Search:
Domain Name
Domain ID
Source
Calcineurin-like_PHP_ApaH
IPR004843
InterPro
Metallo-depent_PP-like
IPR029052
InterPro
Metallophos
PF00149
Pfam
PP2Ac
SM00156
SMART
S35699
S35699
PIR
S35700
S35700
PIR
Ser/Thr-sp_prot-phosphatase
IPR006186
InterPro
SER_THR_PHOSPHATASE
PS00125
PROSITE
SSF56300
SSF56300
SUPFAM
STPHPHTASE
PR00114
PRINTS
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