Protein: P36873

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P36873 (Uniprot) PP1G_HUMAN PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit human No
Uniprot: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169, 534 GO:0006725 cellular aromatic compound metabolic process 345, 585 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2 GO:0044267 cellular protein metabolic process
2 GO:0010467 gene expression
2 GO:0006139 nucleobase-containing compound metabolic process
2 GO:0060255 regulation of macromolecule metabolic process
2 GO:0007165 signal transduction
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
26 GO:0006464 cellular protein modification process
26 GO:0090304 nucleic acid metabolic process
26 GO:0010468 regulation of gene expression
51 GO:0060255 regulation of macromolecule metabolic process
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
107 GO:0016070 RNA metabolic process
107 GO:0044267 cellular protein metabolic process
107 GO:0034654 nucleobase-containing compound biosynthetic process
107 GO:2000112 regulation of cellular macromolecule biosynthetic process
107 GO:0010468 regulation of gene expression
107 GO:0019219 regulation of nucleobase-containing compound metabolic process
107 GO:0007165 signal transduction
116 GO:0019538 protein metabolic process
116 GO:0060255 regulation of macromolecule metabolic process
122 GO:0016070 RNA metabolic process
122 GO:0044271 cellular nitrogen compound biosynthetic process
122 GO:0006464 cellular protein modification process
122 GO:0031324 negative regulation of cellular metabolic process
122 GO:0010605 negative regulation of macromolecule metabolic process
122 GO:0051172 negative regulation of nitrogen compound metabolic process
122 GO:2000112 regulation of cellular macromolecule biosynthetic process
122 GO:0010468 regulation of gene expression
122 GO:0019219 regulation of nucleobase-containing compound metabolic process
122 GO:0007165 signal transduction
124 GO:0010467 gene expression
124 GO:0090304 nucleic acid metabolic process
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
247 GO:0006464 cellular protein modification process
247 GO:0060255 regulation of macromolecule metabolic process
247 GO:0007165 signal transduction
292 GO:0044267 cellular protein metabolic process
292 GO:0010467 gene expression
301 GO:0006464 cellular protein modification process
301 GO:0060255 regulation of macromolecule metabolic process
314 GO:0010467 gene expression
314 GO:0060255 regulation of macromolecule metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
345 GO:0006139 nucleobase-containing compound metabolic process
345 GO:0060255 regulation of macromolecule metabolic process
357 GO:0071310 cellular response to organic substance
357 GO:0031324 negative regulation of cellular metabolic process
357 GO:0010605 negative regulation of macromolecule metabolic process
357 GO:0051172 negative regulation of nitrogen compound metabolic process
357 GO:0031325 positive regulation of cellular metabolic process
357 GO:0010604 positive regulation of macromolecule metabolic process
357 GO:0051173 positive regulation of nitrogen compound metabolic process
357 GO:0009966 regulation of signal transduction
357 GO:0006357 regulation of transcription from RNA polymerase II promoter
362 GO:0006464 cellular protein modification process
362 GO:0060255 regulation of macromolecule metabolic process
380 GO:0010467 gene expression
380 GO:0019538 protein metabolic process
380 GO:0060255 regulation of macromolecule metabolic process
464 GO:0016070 RNA metabolic process
464 GO:0010467 gene expression
482 GO:0006464 cellular protein modification process
482 GO:0007167 enzyme linked receptor protein signaling pathway
482 GO:0006796 phosphate-containing compound metabolic process
482 GO:0032268 regulation of cellular protein metabolic process
482 GO:0009966 regulation of signal transduction
516 GO:0019538 protein metabolic process
521 GO:0060255 regulation of macromolecule metabolic process
534 GO:0007166 cell surface receptor signaling pathway
534 GO:0006464 cellular protein modification process
534 GO:0033554 cellular response to stress
534 GO:0010467 gene expression
534 GO:0006796 phosphate-containing compound metabolic process
534 GO:0060255 regulation of macromolecule metabolic process
534 GO:0009966 regulation of signal transduction
534 GO:0009628 response to abiotic stimulus
577 GO:0006464 cellular protein modification process
577 GO:0033554 cellular response to stress
577 GO:0006796 phosphate-containing compound metabolic process
577 GO:0031326 regulation of cellular biosynthetic process
577 GO:0010556 regulation of macromolecule biosynthetic process
577 GO:0009966 regulation of signal transduction
585 GO:0006139 nucleobase-containing compound metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
714 GO:0016070 RNA metabolic process
714 GO:0010468 regulation of gene expression
798 GO:0016070 RNA metabolic process
798 GO:0010467 gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2 GO:0005829 cytosol
2 GO:0005634 nucleus
25 GO:0005829 cytosol
25 GO:0005634 nucleus
26 GO:0005654 nucleoplasm
51 GO:0005634 nucleus
105 GO:0005634 nucleus
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
107 GO:0005829 cytosol
107 GO:0005654 nucleoplasm
116 GO:0005829 cytosol
116 GO:0070013 intracellular organelle lumen
116 GO:0005634 nucleus
122 GO:0005829 cytosol
122 GO:0043232 intracellular non-membrane-bounded organelle
122 GO:0005654 nucleoplasm
124 GO:0031981 nuclear lumen
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
179 GO:0012505 endomembrane system
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
190 GO:0005829 cytosol
190 GO:0043232 intracellular non-membrane-bounded organelle
247 GO:0005634 nucleus
292 GO:0043232 intracellular non-membrane-bounded organelle
292 GO:0031981 nuclear lumen
301 GO:0005829 cytosol
301 GO:0005634 nucleus
314 GO:0005829 cytosol
314 GO:0005634 nucleus
317 GO:0005829 cytosol
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
345 GO:0070013 intracellular organelle lumen
345 GO:0005634 nucleus
357 GO:0005654 nucleoplasm
361 GO:0005829 cytosol
362 GO:0070013 intracellular organelle lumen
362 GO:0005634 nucleus
380 GO:0005634 nucleus
443 GO:0005829 cytosol
443 GO:0005634 nucleus
464 GO:0070013 intracellular organelle lumen
464 GO:0005634 nucleus
482 GO:0005576 extracellular region
501 GO:0031090 organelle membrane
516 GO:0005634 nucleus
521 GO:0070013 intracellular organelle lumen
521 GO:0005634 nucleus
522 GO:0005634 nucleus
534 GO:0005829 cytosol
534 GO:0012505 endomembrane system
534 GO:0005654 nucleoplasm
577 GO:0005829 cytosol
577 GO:0043232 intracellular non-membrane-bounded organelle
577 GO:0070013 intracellular organelle lumen
577 GO:0044428 nuclear part
577 GO:0031982 vesicle
585 GO:0031981 nuclear lumen
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
714 GO:0031981 nuclear lumen
739 GO:0043232 intracellular non-membrane-bounded organelle
739 GO:0005654 nucleoplasm
798 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0005977 glycogen metabolic process IEA
GO:0006470 protein dephosphorylation IMP
GO:0007062 sister chromatid cohesion TAS
GO:0030182 neuron differentiation IEA
GO:0032922 circadian regulation of gene expression ISS
GO:0042752 regulation of circadian rhythm IMP
GO:0043153 entrainment of circadian clock by photoperiod ISS
GO:0046822 regulation of nucleocytoplasmic transport IEA
GO:0051301 cell division IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000777 condensed chromosome kinetochore IEA
GO:0000784 nuclear chromosome, telomeric region IDA
GO:0005634 nucleus IDA
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IDA
GO:0005741 mitochondrial outer membrane IEA
GO:0005829 cytosol TAS
GO:0005925 focal adhesion IDA
GO:0016607 nuclear speck IEA
GO:0030496 midbody IEA
GO:0032154 cleavage furrow IEA
GO:0043197 dendritic spine IEA
GO:0043234 protein complex IMP
GO:0072357 PTW/PP1 phosphatase complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
ASPP2_HUMAN No
ENKD1_HUMAN No
MTNB_HUMAN No
SKP1_HUMAN Yes: P63208 (MoonDB)
KRCC1_HUMAN No
PPR18_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
A1DRY3_HUMAN No
ABT1_HUMAN No
ACAD8_HUMAN No
ANR42_HUMAN No
ARF_HUMAN No
ASH2L_HUMAN No
ASPP1_HUMAN No
ATD3A_HUMAN No
ATM_HUMAN No
B2CL1_HUMAN No
B4GA1_HUMAN No
BCL2_HUMAN No
BIRC5_HUMAN No
BMPR2_HUMAN No
BTBDA_HUMAN No
C1QA_HUMAN No
CATL1_HUMAN No
CC85B_HUMAN No
CC85C_HUMAN No
CCND1_HUMAN No
CCND3_HUMAN No
CD2B2_HUMAN No
CDCA2_HUMAN No
CDK1_HUMAN No
CDK2_HUMAN No
CDK4_HUMAN No
CE126_HUMAN No
CI050_HUMAN No
CK074_HUMAN No
CLH1_HUMAN Yes: Q00610 (MoonDB)
CLMN_HUMAN No
CLOCK_HUMAN No
CNST_HUMAN No
CO059_HUMAN No
CSK2B_HUMAN Yes: P67870 (MoonDB)
CSN5_HUMAN No
CSRN1_HUMAN No
CSRN2_HUMAN No
CYFP1_HUMAN No
D39U1_HUMAN No
DACT1_HUMAN No
DEAF1_HUMAN No
DEC1_HUMAN No
DYRK4_HUMAN No
ELP4_HUMAN No
ERBIN_HUMAN No
ESR1_HUMAN Yes: P03372 (MoonDB)
EST1A_HUMAN No
FBW1B_HUMAN No
FBXL2_HUMAN No
FRIL_HUMAN No
FXYD6_HUMAN No
GLB1L_HUMAN No
GOGA7_HUMAN No
HDAC6_HUMAN No
HMGN1_HUMAN No
IF2A_HUMAN No
IL3RA_HUMAN No
IMA1_HUMAN No
IMB1_HUMAN No
IPP2M_HUMAN No
IPP2_HUMAN No
JAK2_HUMAN No
KC1A_HUMAN No
KC1E_HUMAN No
KCD20_HUMAN No
KDM4D_HUMAN No
KI67_HUMAN No
LARGN_HUMAN No
LMTK1_HUMAN No
LMTK2_HUMAN No
M4K4_HUMAN No
MAAI_HUMAN No
MAX_HUMAN No
NAPEP_HUMAN No
NEB2_HUMAN No
NEK2_HUMAN No
NMT2_HUMAN No
NRBP_HUMAN No
NUAK1_HUMAN No
NUP50_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PCNA_HUMAN Yes: P12004 (MoonDB)
PDRG1_HUMAN No
PEAK1_HUMAN No
PFD2_HUMAN No
PFD6_HUMAN No
PHAR4_HUMAN No
PHC1_HUMAN No
PIAS1_HUMAN No
PP16A_HUMAN No
PP1A_HUMAN Yes: P62136 (MoonDB)
PP1R7_HUMAN No
PP1R8_HUMAN No
PP1RA_HUMAN No
PP1RB_HUMAN No
PPR32_HUMAN No
PPR35_HUMAN No
PPR3C_HUMAN No
PPR3D_HUMAN No
PR15B_HUMAN No
Q38J66_HUMAN No
Q8WXF2_HUMAN No
Q9BS83_HUMAN No
RANB9_HUMAN No
RASF7_HUMAN No
RIF1_HUMAN No
RIR1_HUMAN No
RL3_HUMAN No
RL7_HUMAN No
RL8_HUMAN No
RMP_HUMAN No
RN19B_HUMAN No
RORG_HUMAN No
RPA43_HUMAN No
RPAB1_HUMAN No
RPAP3_HUMAN No
RPRD2_HUMAN No
RRP1B_HUMAN No
RS11_HUMAN No
RUVB2_HUMAN No
SFRP1_HUMAN No
SGCE_HUMAN No
SH3R2_HUMAN No
SHAN3_HUMAN No
SIN3B_HUMAN No
SNCAP_HUMAN No
SPC1L_HUMAN No
SPOC1_HUMAN No
STAM1_HUMAN No
STAR9_HUMAN No
STAU1_HUMAN No
T120A_HUMAN No
TACC2_HUMAN No
TBC19_HUMAN No
TC1D4_HUMAN No
TEFM_HUMAN No
TENS1_HUMAN No
TEX36_HUMAN No
TOIP1_HUMAN No
TOPB1_HUMAN No
TOX4_HUMAN No
TPRN_HUMAN No
TRA2A_HUMAN No
UB2R1_HUMAN No
UXT_HUMAN No
VDR_HUMAN Yes: P11473 (MoonDB)
VSTM4_HUMAN No
WBP11_HUMAN No
WDR82_HUMAN No
WDR92_HUMAN No
YLPM1_HUMAN No
ZDBF2_HUMAN No
ZFYV9_HUMAN No
ZN318_HUMAN No
ZN667_HUMAN No
ZNF24_HUMAN No
PMID Article Title
7500362 Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate.
7556599 The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.
8111128 Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA.
8394140 Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2.
9414128 PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1.
11535607 Crystal structure of the tumor-promoter okadaic acid bound to protein phosphatase-1.
11564868 Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
11739654 Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.
12226088 Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.
12529430 Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle.
15280359 Crystal structure and mutagenesis of a protein phosphatase-1:calcineurin hybrid elucidate the role of the beta12-beta13 loop in inhibitor binding.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15659832 Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception.
15705855 A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
16492807 Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability.
17283141 Protein phosphatase-1alpha regulates centrosome splitting through Nek2.
17936702 S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling.
17965019 NOM1 targets protein phosphatase I to the nucleolus.
18669648 A quantitative atlas of mitotic phosphorylation.
19377461 GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis.
20516061 Identification and characterization of a novel human PP1 phosphatase complex.
20926688 RRP1B targets PP1 to mammalian cell nucleoli and is associated with pre-60S ribosomal subunits.
21269460 Initial characterization of the human central proteome.
21712997 Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23396208 Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24867636 Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
Calcineurin-like_PHP_ApaH IPR004843 InterPro
Ser/Thr-sp_prot-phosphatase IPR006186 InterPro
Metallo-depent_PP-like IPR029052 InterPro
STPPase_N IPR031675 InterPro
Metallophos PF00149 Pfam
STPPase_N PF16891 Pfam
STPHPHTASE PR00114 PRINTS
SER_THR_PHOSPHATASE PS00125 PROSITE
S35699 S35699 PIR
S35700 S35700 PIR
PP2Ac SM00156 SMART
SSF56300 SSF56300 SUPFAM