Protein: P03372

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P03372 (Uniprot) ESR1_HUMAN ESR1 Estrogen receptor human No
Uniprot: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006139 nucleobase-containing compound metabolic process 592 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
155 GO:0006464 cellular protein modification process
155 GO:0060255 regulation of macromolecule metabolic process
165 GO:0006464 cellular protein modification process
165 GO:0070887 cellular response to chemical stimulus
165 GO:0031325 positive regulation of cellular metabolic process
165 GO:0010604 positive regulation of macromolecule metabolic process
165 GO:0051173 positive regulation of nitrogen compound metabolic process
165 GO:0051246 regulation of protein metabolic process
165 GO:0006355 regulation of transcription, DNA-templated
165 GO:0007165 signal transduction
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
592 GO:0090304 nucleic acid metabolic process
592 GO:0034654 nucleobase-containing compound biosynthetic process
606 GO:0019538 protein metabolic process
606 GO:0006355 regulation of transcription, DNA-templated
606 GO:0007165 signal transduction
606 GO:0006366 transcription from RNA polymerase II promoter
626 GO:0006915 apoptotic process
626 GO:0044267 cellular protein metabolic process
626 GO:0071310 cellular response to organic substance
626 GO:0051253 negative regulation of RNA metabolic process
626 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
626 GO:0010629 negative regulation of gene expression
626 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
626 GO:0010941 regulation of cell death
626 GO:0009966 regulation of signal transduction
626 GO:0009719 response to endogenous stimulus
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
731 GO:0044267 cellular protein metabolic process
731 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
731 GO:0010629 negative regulation of gene expression
731 GO:0045934 negative regulation of nucleobase-containing compound metabolic process
731 GO:0010604 positive regulation of macromolecule metabolic process
731 GO:0006357 regulation of transcription from RNA polymerase II promoter
731 GO:0007165 signal transduction
867 GO:0044267 cellular protein metabolic process
867 GO:0071495 cellular response to endogenous stimulus
867 GO:0071310 cellular response to organic substance
867 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
867 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
155 GO:0005634 nucleus
165 GO:0005829 cytosol
165 GO:0043232 intracellular non-membrane-bounded organelle
165 GO:0005654 nucleoplasm
169 GO:0005654 nucleoplasm
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
388 GO:0016021 integral component of membrane
592 GO:0005634 nucleus
606 GO:0005829 cytosol
606 GO:0031981 nuclear lumen
626 GO:0005829 cytosol
626 GO:0005654 nucleoplasm
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
731 GO:0005654 nucleoplasm
867 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0001547 antral ovarian follicle growth IEA
GO:0002064 epithelial cell development IEA
GO:0006338 chromatin remodeling NAS
GO:0006351 transcription, DNA-templated TAS
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0006366 transcription from RNA polymerase II promoter IDA
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0007165 signal transduction TAS
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS
GO:0007204 positive regulation of cytosolic calcium ion concentration ISS
GO:0008209 androgen metabolic process IEA
GO:0008584 male gonad development IEA
GO:0010629 negative regulation of gene expression IDA
GO:0010863 positive regulation of phospholipase C activity ISS
GO:0016579 protein deubiquitination TAS
GO:0030111 regulation of Wnt signaling pathway TAS
GO:0030518 intracellular steroid hormone receptor signaling pathway ISS
GO:0030520 intracellular estrogen receptor signaling pathway IDA
GO:0032355 response to estradiol IDA
GO:0033146 regulation of intracellular estrogen receptor signaling pathway TAS
GO:0034121 regulation of toll-like receptor signaling pathway IEA
GO:0042981 regulation of apoptotic process IEA
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
GO:0043433 negative regulation of DNA binding transcription factor activity IDA
GO:0043627 response to estrogen IDA
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048146 positive regulation of fibroblast proliferation IEA
GO:0048863 stem cell differentiation IEA
GO:0050727 regulation of inflammatory response IEA
GO:0051091 positive regulation of DNA binding transcription factor activity IDA
GO:0060065 uterus development IEA
GO:0060068 vagina development IEA
GO:0060523 prostate epithelial cord elongation IEA
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
GO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
GO:0060745 mammary gland branching involved in pregnancy IEA
GO:0060749 mammary gland alveolus development IEA
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IEA
GO:0071168 protein localization to chromatin IMP
GO:0071391 cellular response to estrogen stimulus IEA
GO:0071392 cellular response to estradiol stimulus IDA
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005794 Golgi apparatus IEA
GO:0005886 plasma membrane IDA
GO:0016020 membrane NAS
GO:0016021 integral component of membrane IEA
GO:0035327 transcriptionally active chromatin IDA
GO:0043234 protein complex IMP
GO:0097550 transcriptional preinitiation complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0000790 nuclear chromatin GO:0005886 plasma membrane 1.05e-21 5.03e-79
GO:0000790 nuclear chromatin GO:0016020 membrane 3.99e-39 3.29e-131
GO:0000790 nuclear chromatin GO:0016021 integral component of membrane 1.62e-33 6.67e-171
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005654 nucleoplasm GO:0005794 Golgi apparatus 1.14e-11 3.23e-62
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005654 nucleoplasm GO:0016021 integral component of membrane 0.00e+00 0.00e+00
GO:0005737 cytoplasm GO:0016021 integral component of membrane 2.01e-156 1.16e-04
GO:0016021 integral component of membrane GO:0043234 protein complex 6.03e-79 2.03e-37
Interactor Also a MoonDB EMF protein
ARI5A_HUMAN No
FHL2_HUMAN No
RBM39_HUMAN No
KAT5_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
PP1G_HUMAN Yes: P36873 (MoonDB)
MED25_HUMAN No
HDAC4_HUMAN No
LCOR_HUMAN No
PPP5_HUMAN No
ESR2_HUMAN Yes: Q92731 (MoonDB)
NSD1_HUMAN Yes: Q96L73 (MoonDB)
UBC9_HUMAN Yes: P63279 (MoonDB)
RNF4_HUMAN No
PIAS1_HUMAN No
SRC_HUMAN Yes: P12931 (MoonDB)
MEN1_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
EP300_HUMAN Yes: Q09472 (MoonDB)
TADA3_HUMAN No
MDM2_HUMAN Yes: Q00987 (MoonDB)
SMCA2_HUMAN No
SMCA4_HUMAN No
UIMC1_HUMAN No
CBP_HUMAN No
SPF27_HUMAN No
ESIP1_HUMAN No
ANGL4_HUMAN No
HOP2_HUMAN No
KLK5_HUMAN No
NRIP1_HUMAN No
NR0B2_HUMAN No
PTN1_HUMAN No
GLCE_HUMAN No
NSD3_HUMAN No
NCOR2_HUMAN No
DDX5_HUMAN No
ANM2_HUMAN No
GROA_HUMAN No
SPB5_HUMAN No
BAP1_HUMAN No
TRAM1_HUMAN No
CCND1_HUMAN No
PNRC2_HUMAN No
AKP13_HUMAN No
ANF_HUMAN No
ATAD2_HUMAN No
BTF3_HUMAN No
COF1_HUMAN No
COT1_HUMAN No
CSRP1_HUMAN No
DDX17_HUMAN No
DDX54_HUMAN No
DUT_HUMAN No
FOXK2_HUMAN No
FOXO1_HUMAN No
GRIP1_HUMAN No
HAKAI_HUMAN No
HBP1_HUMAN No
KIF1A_HUMAN No
KLK9_HUMAN No
L3R2A_HUMAN No
MED1_HUMAN No
MGMT_HUMAN No
MPIP2_HUMAN No
MTCH2_HUMAN No
NCOA1_HUMAN No
NCOA2_HUMAN No
NCOA3_HUMAN Yes: Q9Y6Q9 (MoonDB)
NCOA6_HUMAN No
NCOR1_HUMAN No
PHB2_HUMAN No
PO4F1_HUMAN No
PO4F2_HUMAN No
PRDM2_HUMAN No
PRGC2_HUMAN No
PRGR_HUMAN No
PTN6_HUMAN Yes: P29350 (MoonDB)
RAC3_HUMAN No
SRA1_HUMAN No
SVIL_HUMAN No
TAF2_HUMAN No
TDIF2_HUMAN No
TRRAP_HUMAN No
TRXR1_HUMAN No
UBE4B_HUMAN No
PMID Article Title
1577818 Characterization of a temperature-sensitive mutation in the hormone binding domain of the human estrogen receptor. Studies in cell extracts and intact cells and their implications for hormone-dependent transcriptional activation.
2247153 Solution structure of the DNA-binding domain of the oestrogen receptor.
2792078 The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.
3753802 Sequence and expression of human estrogen receptor complementary DNA.
3754034 Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
7476978 Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor.
7539106 Phosphorylation of the human estrogen receptor on tyrosine 537 in vivo and by src family tyrosine kinases in vitro.
7651415 Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta.
7838153 Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor.
7916651 Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines.
8221895 The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
8600466 A novel 80 kDa human estrogen receptor containing a duplication of exons 6 and 7.
8961262 A transcriptionally active estrogen receptor mutant is a novel type of dominant negative inhibitor of estrogen action.
8999954 A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine.
9195227 Screening for ESR mutations in breast and ovarian cancer patients.
9328340 Functional synergy between the transcription factor Sp1 and the estrogen receptor.
9338790 Molecular basis of agonism and antagonism in the oestrogen receptor.
9600906 Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
9619507 Homology model for the ligand-binding domain of the human estrogen receptor.
9627117 Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action.
9875847 The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
10359819 An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.
10409727 Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.
10428798 Potentiation of human estrogen receptor alpha transcriptional activation through phosphorylation of serines 104 and 106 by the cyclin A-CDK2 complex.
10567404 A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
10619354 Single nucleotide polymorphisms (SNPs) in the estrogen receptor gene and breast cancer susceptibility.
10681512 Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements.
10816575 Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins.
10942433 Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor alpha gene and their relationship to bone mass variation in postmenopausal Italian women.
10970861 Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1.
11075817 Function of N-terminal transactivation domain of the estrogen receptor requires a potential alpha-helical structure and is negatively regulated by the A domain.
11113208 CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.
11265755 Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.
11358960 Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription.
11477071 Characterization of the physical interaction between estrogen receptor alpha and JUN proteins.
11581164 Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.
11682626 Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains.
11875103 A negative coregulator for the human ER.
11971969 ERAP140, a conserved tissue-specific nuclear receptor coactivator.
12039952 Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
12093804 Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor.
12415108 Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
12554772 Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells.
12682286 Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells.
12917342 BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.
14574404 The DNA sequence and analysis of human chromosome 6.
14764652 Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription.
15047147 ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.
15078875 The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell.
15199063 An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15891768 Functional regulation of oestrogen receptor pathway by the dynein light chain 1.
15940264 The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1.
16043358 Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation.
16165085 Identification, cloning, and expression of human estrogen receptor-alpha36, a novel variant of human estrogen receptor-alpha66.
16427018 MUC1 oncoprotein stabilizes and activates estrogen receptor alpha.
16603732 Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.
16617102 MTA1, a transcriptional activator of breast cancer amplified sequence 3.
16684779 Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.
16772533 WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.
17006958 MS-KIF18A, a kinesin, is associated with estrogen receptor.
17043237 An inherent role of microtubule network in the action of nuclear receptor.
17085477 ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases.
17224074 Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.
17311814 Ubiquitin-interaction motifs of RAP80 are critical in its regulation of estrogen receptor alpha.
17347654 CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome.
17505058 Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).
17587566 PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
17658481 The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain.
17914104 Estrogenically regulated LRP16 interacts with estrogen receptor alpha and enhances the receptor's transcriptional activity.
17922032 MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene.
17932106 CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
17974005 The full-ORF clone resource of the German cDNA consortium.
17998543 ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.
18247370 ERalpha and AP-1 interact in vivo with a specific sequence of the F promoter of the human ERalpha gene in osteoblasts.
18563714 ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.
18657504 Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
19117995 Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.
19339517 CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.
19350539 NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells.
19383985 OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.
19423554 Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia.
19636373 The regulation of MS-KIF18A expression and cross talk with estrogen receptor.
19712589 SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway.
19718048 The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.
19749156 G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.
19755138 Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.
20074560 Repression of estrogen receptor beta function by putative tumor suppressor DBC1.
20705611 Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.
20720010 ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells.
21104395 Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand.
21330404 Multiple sequence-specific DNA-binding proteins mediate estrogen receptor signaling through a tethering pathway.
21602804 Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.
21937726 Splice isoform estrogen receptors as integral transmembrane proteins.
22031296 DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.
22083956 CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter.
23160374 CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha.
23841731 Delayed puberty and estrogen resistance in a woman with estrogen receptor alpha variant.
23874500 DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.
25219498 Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.
27754803 Familial multiplicity of estrogen insensitivity associated with a loss-of-function ESR1 mutation.
28068668 The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha.
OMIM ID Disease Name
615363 Estrogen resistance
Domain Name Domain ID Source
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Oestr_rcpt IPR001292 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Znf_NHR/GATA IPR013088 InterPro
Oest_rcpt/oest-rel_rcp IPR024178 InterPro
Oestrogen-typ_rcpt_final_C_dom IPR024736 InterPro
NHR_like_dom_sf IPR035500 InterPro
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
Oest_recep PF02159 Pfam
ESR1_C PF12743 Pfam
ER-like_NR PIRSF002527 PIRSF
ER-a PIRSF500101 PIRSF
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
OESTROGENR PR00543 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
S64737 S64737 PIR
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM