Protein: Q15637 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q15637 (Uniprot)	SF01_HUMAN	SF1	Splicing factor 1	human	No

Protein Function

Uniprot: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006396	RNA processing	426	GO:0036211	protein modification process	440	5.60e-03	3.14e-16
GO:0019538	protein metabolic process	215	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 68 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
139	GO:0023051	regulation of signaling
139	GO:0007165	signal transduction
167	GO:0016070	RNA metabolic process
167	GO:0010467	gene expression
167	GO:0060255	regulation of macromolecule metabolic process
189	GO:0090304	nucleic acid metabolic process
191	GO:0006355	regulation of transcription, DNA-templated
215	GO:0044267	cellular protein metabolic process
215	GO:0007167	enzyme linked receptor protein signaling pathway
215	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
60	GO:0005634	nucleus
167	GO:0005654	nucleoplasm
189	GO:0005634	nucleus
191	GO:0031981	nuclear lumen
215	GO:0012505	endomembrane system
215	GO:0005886	plasma membrane
215	GO:0031982	vesicle
259	GO:0005886	plasma membrane
327	GO:0005829	cytosol
327	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 11 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000245	spliceosomal complex assembly	NAS
GO:0000389	mRNA 3'-splice site recognition	TAS
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0006351	transcription, DNA-templated	IEA
GO:0006355	regulation of transcription, DNA-templated	IEA
GO:0030238	male sex determination	IEA
GO:0030575	nuclear body organization	IEA
GO:0033327	Leydig cell differentiation	IEA
GO:0048662	negative regulation of smooth muscle cell proliferation	IEA
GO:0050810	regulation of steroid biosynthetic process	IEA

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Cellular Components

Showing 1 to 5 of 5 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	NAS
GO:0005654	nucleoplasm	TAS
GO:0005681	spliceosomal complex	IDA
GO:0005840	ribosome	NAS
GO:0016604	nuclear body	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 82 entries

Search:

Interactor	Also a MoonDB EMF protein
ABL1_HUMAN	Yes: P00519 (MoonDB)
ABL2_HUMAN	Yes: P42684 (MoonDB)
ANM2_HUMAN	No
ATX1_HUMAN	Yes: P54253 (MoonDB)
BLOM7_HUMAN	No
CD2B2_HUMAN	No
CE104_HUMAN	No
CENPI_HUMAN	No
CHERP_HUMAN	Yes: Q8IWX8 (MoonDB)
CIAO1_HUMAN	No

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Publications Associated

Showing 1 to 10 of 27 entries

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PMID	Article Title
7912130	Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).
8752089	Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.
9192847	Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins.
9573336	Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene.
9660765	The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
10449420	Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.
11691992	Structural basis for recognition of the intron branch site RNA by splicing factor 1.
12176931	Large-scale proteomic analysis of the human spliceosome.
12718882	Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 17 entries

Search:

Domain Name	Domain ID	Source
BBP/SF1	IPR031150	InterPro
G02919	G02919	PIR
KH	SM00322	SMART
KH_1	PF00013	Pfam
KH_dom	IPR004087	InterPro
KH_dom_type_1	IPR004088	InterPro
KH_dom_type_1_sf	IPR036612	InterPro
KH_TYPE_1	PS50084	PROSITE
PTHR11208:SF45	PTHR11208:SF45	PANTHER
SF1-HH	IPR032570	InterPro

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