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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q15637
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q15637 (Uniprot)
SF01_HUMAN
SF1
Splicing factor 1
human
No
Protein Function
Uniprot:
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
MoonDB Dissimilar Functions
Showing 1 to 2 of 2 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006396
RNA processing
426
GO:0036211
protein modification process
440
5.60e-03
3.14e-16
GO:0019538
protein metabolic process
215
GO:0000377
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
467
1.88e-02
4.66e-37
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 68 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
139
GO:0023051
regulation of signaling
139
GO:0007165
signal transduction
167
GO:0016070
RNA metabolic process
167
GO:0010467
gene expression
167
GO:0060255
regulation of macromolecule metabolic process
189
GO:0090304
nucleic acid metabolic process
191
GO:0006355
regulation of transcription, DNA-templated
215
GO:0044267
cellular protein metabolic process
215
GO:0007167
enzyme linked receptor protein signaling pathway
215
GO:0010467
gene expression
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Cellular Components
Showing 1 to 10 of 31 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
60
GO:0005634
nucleus
167
GO:0005654
nucleoplasm
189
GO:0005634
nucleus
191
GO:0031981
nuclear lumen
215
GO:0012505
endomembrane system
215
GO:0005886
plasma membrane
215
GO:0031982
vesicle
259
GO:0005886
plasma membrane
327
GO:0005829
cytosol
327
GO:0043232
intracellular non-membrane-bounded organelle
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Protein GO Annotations
Biological Processes
Showing 1 to 10 of 11 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000245
spliceosomal complex assembly
NAS
GO:0000389
mRNA 3'-splice site recognition
TAS
GO:0000398
mRNA splicing, via spliceosome
TAS
GO:0006351
transcription, DNA-templated
IEA
GO:0006355
regulation of transcription, DNA-templated
IEA
GO:0030238
male sex determination
IEA
GO:0030575
nuclear body organization
IEA
GO:0033327
Leydig cell differentiation
IEA
GO:0048662
negative regulation of smooth muscle cell proliferation
IEA
GO:0050810
regulation of steroid biosynthetic process
IEA
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
NAS
GO:0005654
nucleoplasm
TAS
GO:0005681
spliceosomal complex
IDA
GO:0005840
ribosome
NAS
GO:0016604
nuclear body
IEA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 82 entries
Search:
Interactor
Also a MoonDB EMF protein
ABL1_HUMAN
Yes:
P00519 (MoonDB)
ABL2_HUMAN
Yes:
P42684 (MoonDB)
ANM2_HUMAN
No
ATX1_HUMAN
Yes:
P54253 (MoonDB)
BLOM7_HUMAN
No
CD2B2_HUMAN
No
CE104_HUMAN
No
CENPI_HUMAN
No
CHERP_HUMAN
Yes:
Q8IWX8 (MoonDB)
CIAO1_HUMAN
No
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Publications Associated
Showing 1 to 10 of 27 entries
Search:
PMID
Article Title
7912130
Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).
8752089
Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.
9192847
Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins.
9573336
Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene.
9660765
The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
10449420
Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.
11691992
Structural basis for recognition of the intron branch site RNA by splicing factor 1.
12176931
Large-scale proteomic analysis of the human spliceosome.
12718882
Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 17 entries
Search:
Domain Name
Domain ID
Source
BBP/SF1
IPR031150
InterPro
G02919
G02919
PIR
KH
SM00322
SMART
KH_1
PF00013
Pfam
KH_dom
IPR004087
InterPro
KH_dom_type_1
IPR004088
InterPro
KH_dom_type_1_sf
IPR036612
InterPro
KH_TYPE_1
PS50084
PROSITE
PTHR11208:SF45
PTHR11208:SF45
PANTHER
SF1-HH
IPR032570
InterPro
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