Protein: Q15637

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q15637 (Uniprot) SF01_HUMAN SF1 Splicing factor 1 human No
Uniprot: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 215 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
GO:0006396 RNA processing 426 GO:0036211 protein modification process 440 5.60e-03 3.14e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
139 GO:0023051 regulation of signaling
139 GO:0007165 signal transduction
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
189 GO:0090304 nucleic acid metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
259 GO:0007165 signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
384 GO:0034645 cellular macromolecule biosynthetic process
384 GO:0006464 cellular protein modification process
384 GO:0090304 nucleic acid metabolic process
384 GO:0031326 regulation of cellular biosynthetic process
384 GO:0060255 regulation of macromolecule metabolic process
384 GO:0007165 signal transduction
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
492 GO:0044271 cellular nitrogen compound biosynthetic process
492 GO:0051252 regulation of RNA metabolic process
492 GO:2000112 regulation of cellular macromolecule biosynthetic process
492 GO:0010468 regulation of gene expression
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
585 GO:0006139 nucleobase-containing compound metabolic process
591 GO:0016070 RNA metabolic process
591 GO:0010467 gene expression
591 GO:0060255 regulation of macromolecule metabolic process
747 GO:0010467 gene expression
747 GO:0090304 nucleic acid metabolic process
834 GO:0051252 regulation of RNA metabolic process
834 GO:2000112 regulation of cellular macromolecule biosynthetic process
834 GO:0010468 regulation of gene expression
834 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
167 GO:0005654 nucleoplasm
189 GO:0005634 nucleus
191 GO:0031981 nuclear lumen
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
259 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
384 GO:0005829 cytosol
384 GO:0031981 nuclear lumen
426 GO:0005654 nucleoplasm
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
492 GO:0044428 nuclear part
563 GO:0005634 nucleus
585 GO:0031981 nuclear lumen
591 GO:0031981 nuclear lumen
641 GO:0005634 nucleus
747 GO:0070013 intracellular organelle lumen
747 GO:0005634 nucleus
834 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000245 spliceosomal complex assembly NAS
GO:0000389 mRNA 3'-splice site recognition TAS
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated IEA
GO:0030238 male sex determination IEA
GO:0030575 nuclear body organization IEA
GO:0033327 Leydig cell differentiation IEA
GO:0048662 negative regulation of smooth muscle cell proliferation IEA
GO:0050810 regulation of steroid biosynthetic process IEA
GO:1903507 negative regulation of nucleic acid-templated transcription IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus NAS
GO:0005654 nucleoplasm TAS
GO:0005681 spliceosomal complex IDA
GO:0005840 ribosome NAS
GO:0016604 nuclear body IEA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
PSA3_HUMAN Yes: P25788 (MoonDB)
HNRPF_HUMAN No
KHDR3_HUMAN No
ATX1_HUMAN Yes: P54253 (MoonDB)
TIAR_HUMAN No
KR261_HUMAN No
F168A_HUMAN No
SC23A_HUMAN No
CE104_HUMAN No
WWP2_HUMAN Yes: O00308 (MoonDB)
PLS1_HUMAN No
ILF3_HUMAN No
HNRL1_HUMAN No
RBM7_HUMAN No
MD2L2_HUMAN No
CO8A1_HUMAN No
MKRN3_HUMAN Yes: Q13064 (MoonDB)
HNRPK_HUMAN Yes: P61978 (MoonDB)
IMA4_HUMAN No
TRI23_HUMAN No
PLAL2_HUMAN No
SF3B4_HUMAN No
TRI69_HUMAN No
EWS_HUMAN No
ABL1_HUMAN Yes: P00519 (MoonDB)
CIAO1_HUMAN No
CLH1_HUMAN Yes: Q00610 (MoonDB)
ABL2_HUMAN Yes: P42684 (MoonDB)
ANM2_HUMAN No
BLOM7_HUMAN No
CD2B2_HUMAN No
CENPI_HUMAN No
CHERP_HUMAN Yes: Q8IWX8 (MoonDB)
DAZP1_HUMAN No
DDB1_HUMAN No
DDX17_HUMAN No
DDX5_HUMAN No
FA46C_HUMAN No
FUBP3_HUMAN No
HNRDL_HUMAN No
HNRH1_HUMAN No
HNRH2_HUMAN No
HNRPD_HUMAN Yes: Q14103 (MoonDB)
IMA1_HUMAN No
IMA3_HUMAN No
IMA5_HUMAN No
IMA6_HUMAN No
IMA7_HUMAN No
KDM4B_HUMAN No
KHDR1_HUMAN No
MBTD1_HUMAN No
MEP50_HUMAN No
MSI2H_HUMAN No
NLTP_HUMAN No
NU155_HUMAN No
P3C2B_HUMAN No
PHF19_HUMAN No
PKCB1_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
Q59F66_HUMAN No
RBM10_HUMAN Yes: P98175 (MoonDB)
RBM4_HUMAN Yes: Q9BWF3 (MoonDB)
RBM5_HUMAN No
RBMS1_HUMAN No
RBMS2_HUMAN No
ROAA_HUMAN No
SF3A1_HUMAN No
SPF27_HUMAN No
SPF45_HUMAN No
TGS1_HUMAN No
TIA1_HUMAN No
TISB_HUMAN No
TISD_HUMAN No
TITIN_HUMAN Yes: Q8WZ42 (MoonDB)
TPR_HUMAN No
TTP_HUMAN No
U2AF2_HUMAN No
U5S1_HUMAN No
UHMK1_HUMAN No
VAV2_HUMAN Yes: P52735 (MoonDB)
WDR83_HUMAN No
PMID Article Title
7912130 Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1).
8752089 Mammalian splicing factor SF1 is encoded by variant cDNAs and binds to RNA.
9192847 Identification of two novel isoforms of the ZNF162 gene: a growing family of signal transduction and activator of RNA proteins.
9573336 Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene.
9660765 The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
10449420 Phosphorylation of splicing factor SF1 on Ser20 by cGMP-dependent protein kinase regulates spliceosome assembly.
11691992 Structural basis for recognition of the intron branch site RNA by splicing factor 1.
12176931 Large-scale proteomic analysis of the human spliceosome.
12718882 Structural basis for the molecular recognition between human splicing factors U2AF65 and SF1/mBBP.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17589525 U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
18220336 Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
G02919 G02919 PIR
Znf_CCHC IPR001878 InterPro
KH_dom IPR004087 InterPro
KH_dom_type_1 IPR004088 InterPro
BBP/SF1 IPR031150 InterPro
SF1-HH IPR032570 InterPro
KH_dom_type_1_sf IPR036612 InterPro
Znf_CCHC_sf IPR036875 InterPro
KH_1 PF00013 Pfam
zf-CCHC PF00098 Pfam
SF1-HH PF16275 Pfam
KH_TYPE_1 PS50084 PROSITE
ZF_CCHC PS50158 PROSITE
PTHR11208:SF45 PTHR11208:SF45 PANTHER
KH SM00322 SMART
ZnF_C2HC SM00343 SMART
SSF54791 SSF54791 SUPFAM